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Harren Jhoti

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Harren Jhoti
OBEFRSFMedSciFRSBFRSC
Born1962 (age 61–62)[1]
India
Alma mater
Known forAstex Pharmaceuticals
AwardsUK BioIndustry Association (BIA) Lifetime Achievement Award (2018)
European Federation for Medicinal Chemistry Prous Institute-Overton and Meyer Award for New Technologies in Drug Discovery (2012)
Royal Society of ChemistryEntrepreneur of the Year (2007)
Scientific career
FieldsDrug discovery
Structural biology
InstitutionsAstex

GlaxoWellcome

University of Oxford
ThesisX-ray structural studies on transferrins(1989)
Websiteastx/portfolio-item/harren-jhoti/

Harren JhotiOBEFRSFMedSciFRSBFRSC(born 1962[1]) is an Indian-born Britishstructural biologistwhose main interest has been rationaldrug designand discovery.[3][4]He is president andchief executive officer(CEO) of biotechnology companyAstex Pharmaceuticals( "Astex" ) which is located inCambridge,United Kingdom.

Career

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Jhoti co-founded Astex withTom BlundellandChris Abellin 1999.[4][5]He pioneered the development offragment-based drug discovery(FBDD),[3][6][7]an approach now widely used in industry and academia, which identifies small molecules with potential therapeutic potential as part of the drug discovery process. Jhoti was Astex's chief scientific officer until November 2007 when he was appointed CEO. In 2013, Astex was acquired for around USD $900 million[8]and now operates as a wholly owned subsidiary ofOtsuka PharmaceuticalCo. Ltd, headquartered in Tokyo, Japan.

Prior to Astex, Jhoti was head of structural biology atGlaxoWellcome (now GSK).Before founding Astex in 1999, he was head of structural biology and bioinformatics at GlaxoWellcome in the UK (1991-1999). Prior to GlaxoWellcome, Jhoti was a post-doctoral scientist atthe University of Oxford.[citation needed]

Jhoti received both his BSc (Hons) in biochemistry in 1985 and PhD inprotein crystallographyin 1989 from theUniversity of London.

Honours, fellowships and awards

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Jhoti's scientific achievements have been recognised by theRoyal Society,[3]theRoyal Society of Chemistry,theRoyal Society of Biologyand the Academy of Medical Sciences.[9]He has also received the UK BioIndustry Association (BIA)'s Lifetime Achievement Award (2018)[10]and the European Federation for Medicinal Chemistry's Prous Institute-Overton and Meyer Award for New Technologies in Drug Discovery (2012).[4]Jhoti has previously been recognised as the Royal Society of Chemistry's Entrepreneur of the Year Entrepreneur of the Year (2007).[5]He has also served on the board of the BIA between 2013-2015.[11]

Jhoti has been published inNatureandScience,and was featured inTimemagazine after Astex was named a Technology Pioneer by the World Economic Forum in 2005.[12]

Jhoti was appointedOfficer of the Order of the British Empire(OBE) in the2023 New Year Honoursfor services to cancer research and drug discovery.[13]

References

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  1. ^abcAnon (2016)."Jhoti, Dr Harren".Who's Who(onlineOxford University Pressed.). Oxford: A & C Black.doi:10.1093/ww/9780199540884.013.286522.(Subscription orUK public library membershiprequired.)
  2. ^Jhoti, Harren (1989).X-ray structural studies on transferrins.London.ac.uk(PhD thesis).University of London.OCLC940322045.Copac29529053.
  3. ^abcAnon (2018)."Dr Harren Jhoti FRS".Royalsociety.org.London:Royal Society.Archived fromthe originalon 2018-05-14.One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    "All text published under the heading 'Biography' on Fellow profile pages is available underCreative Commons Attribution 4.0 International License."--"Terms, conditions and policies | Royal Society".Archived from the original on 2016-11-11.Retrieved2018-05-23.{{cite web}}:CS1 maint: bot: original URL status unknown (link)
  4. ^abc"Prous Institute - Overton and Meyer Award for New Technologies in Drug Discovery".
  5. ^abHoulton, Sarah (2008)."Keeping it simple - Personal Profile"(PDF).Royal Society of Chemistry.
  6. ^Brackley, Paul (2018)."How Astex founder Dr Harren Jhoti has changed the drug discovery process".Cambridge Independent.
  7. ^Jhoti, Harren; Williams, Glyn; Rees, David C.; Murray, Christopher W. (2013)."The 'rule of three' for fragment-based drug discovery: where are we now?".Nature Reviews Drug Discovery.12(8): 644–645.doi:10.1038/nrd3926-c1.ISSN1474-1776.PMID23845999.Closed access icon
  8. ^"Japan's Otsuka to buy Astex Pharma for about $900 million: Nikkei".Reuters.4 September 2013.Retrieved14 April2021.
  9. ^"Dr Harren Jhoti - The Academy of Medical Sciences".Acmedsci.ac.uk.Retrieved23 May2018.
  10. ^"Harren Jhoti receives BIA Lifetime Achievement Award at gala dinner".Manufacturing Chemist.2018.Retrieved5 May2021.
  11. ^"Harren Jhoti, Appointments".Companies House.Retrieved25 May2021.
  12. ^"Astex chosen by the World Economic Forum as a Technology Pioneer for 2005".Astex.2004.Retrieved25 May2021.
  13. ^"No. 63918".The London Gazette(Supplement). 31 December 2022. p. N14.

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