Hofbauer cell
Hofbauer cellsare ovaleosinophilichistiocytes[1]with granules andvacuolesfound in theplacenta,which are ofmesenchymalorigin, inmesodermof thechorionic villi,particularly numerous in earlypregnancy.
Etymology
[edit]They are named after J. Isfred Isidore Hofbauer (1871[2]-1961),[1]a German-American gynecologist who described the cell type in his bookGrundzüge einer Biologie der menschlichen Plazenta, mit besonderer Berücksichtigung der Fragen der fötalen Ernährung(Biology of the Human Placenta with a special emphasis on the question of fetal nourishment).
Function
[edit]They are believed to be a type ofmacrophage[3][4]and are most likely involved in preventing the transmission ofpathogensfrom the mother to thefetus(vertical transmission). Although there are many studies concerning placental vasculogenesis and angiogenesis, there has been a lack of evidence on the possible roles of Hofbauer cells in these processes.[5]According to a systems level single-cell transcriptomics based study of human placental cell-cell communication, Hofbauer cells produceHBE-GF,an EGFR ligand, which drives differentiation of villous cytotrophoblasts towards syncytiotrophoblasts.[6]
Histology
[edit]
Under histology sections, Hofbauer cells have appeared with discernible amount of cytoplasm.
References
[edit]- ^abVenes, Donald (2006).Taber's cyclopedic medical dictionary(Ed. 20, illustrated in full color. ed.). Philadelphia [Pa.]: Davis Co.ISBN0-8036-1208-7.
- ^"Dr. Isfred Hofbauer, a Gynecologist, 89".The New York Times.1961-03-15.ISSN0362-4331.Retrieved2020-10-05.
- ^Wood, GW. (1980). "Mononuclear phagocytes in the human placenta".Placenta.1(2): 113–23.doi:10.1016/s0143-4004(80)80019-1.PMID7003580.
- ^Zaccheo, D.; Pistoia, V.; Castellucci, M.; Martinoli, C. (1989). "Isolation and characterization of Hofbauer cells from human placental villi".Arch Gynecol Obstet.246(4): 189–200.doi:10.1007/bf00934518.PMID2482706.S2CID30920736.
- ^Seval, Y.; Korgun, ET.; Demir, R. (2007). "Hofbauer cells in early human placenta: possible implications in vasculogenesis and angiogenesis".Placenta.28(8–9): 841–5.doi:10.1016/j.placenta.2007.01.010.PMID17350092.
- ^Vento-Tormo, Roser; Efremova, Mirjana; Botting, Rachel A.; Turco, Margherita Y.; Vento-Tormo, Miquel; Meyer, Kerstin B.; Park, Jong-Eun; Stephenson, Emily; Polański, Krzysztof; Goncalves, Angela; Gardner, Lucy; Holmqvist, Staffan; Henriksson, Johan; Zou, Angela; Sharkey, Andrew M.; Millar, Ben; Innes, Barbara; Wood, Laura; Wilbrey-Clark, Anna; Payne, Rebecca P.; Ivarsson, Martin A.; Lisgo, Steve; Filby, Andrew; Rowitch, David H.; Bulmer, Judith N.; Wright, Gavin J.; Stubbington, Michael J. T.; Haniffa, Muzlifah; Moffett, Ashley; Teichmann, Sarah A. (2018)."Single-cell reconstruction of the early maternal–fetal interface in humans".Nature.563(7731): 347–353.Bibcode:2018Natur.563..347V.doi:10.1038/s41586-018-0698-6.ISSN0028-0836.PMC7612850.PMID30429548.
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