Homeostatic capacity
Homeostatic capacityrefers to the capability of systems to self-stabilize in response to external forces orstressors,or more simply the capability of systems to maintainhomeostasis.[1][2]For livingorganisms,it is life's foundational trait, consisting of a hierarchy and network of traits endowed by nature and shaped by natural selection. Homeostatic capacity comprises amultidimensional networkof traits and operates at all scales ofbiologysystems levels including molecular, cellular, physiological, and organismal.
Human homeostatic capacity
[edit]In the context of human beings, homeostatic capacity refers to the inherent ability of the body to self-stabilize in response to external and internalstimuli.Homeostatic capacity of the human body erodes with age.[3][4][5]
Homeostatic capacity and aging
[edit]A hypothesis proffered by the proponents of the Palo Alto Longevity Prize is that the array of ailments associated with aging may be epiphenomena of eroding homeostatic capacity and the process ofagingmay be halted or reversed by restoring homeostatic capacity to that of a healthy young adult.[6][7][8][9][10]
See also
[edit]References
[edit]- ^Anthony Joonkyoo Yun, MD(2014).Hiding in Plain Sight: Essays by Joon Yun, MD, Second Edition.p. 130.ISBN9781312492028.
- ^"After the last death: Doctors, academics debate the possibility, value of a 150-year lifespan".Palo Alto Online. January 9, 2015.RetrievedJanuary 13,2015.
- ^Novoseltsev VN, Novoseltseva J, Yashin AI (2001). "A homeostatic model of oxidative damage explains paradoxes observed in earlier aging experiments: a fusion and extension of older theories of aging".Biogerontology.2(2): 127–38.doi:10.1023/a:1011511100472.PMID11708379.S2CID6542650.
- ^Rolls BJ, Phillips PA (March 1990). "Aging and disturbances of thirst and fluid balance".Nutr Rev.48(3): 137–44.doi:10.1111/j.1753-4887.1990.tb02915.x.PMID2406645.
- ^Phillips, Paddy A.; Hodsman, G. Peter; Johnston, Colin I. (January 1991). "Neuroendocrine mechanisms and cardiovascular homeostasis in the elderly".Cardiovascular Drugs and Therapy.4(S6): 1209–1213.doi:10.1007/BF00114221.PMID2009244.S2CID32343396.
- ^"FAQ – Palo Alto Longevity Prize".Palo Alto Longevity Prize. Archived fromthe originalon October 6, 2014.RetrievedOctober 1,2014.
- ^Ashlee Vance(September 9, 2014)."Silicon Valley Investor Backs $1 Million Prize to End Death".Bloomberg Businessweek.RetrievedOctober 1,2014.
- ^"$1 Million Longevity Prize Seeks To" Hack The Aging Code ""(Press release).Yahoo! Finance.September 9, 2014.RetrievedOctober 1,2014.
- ^Aaron Kinney (September 14, 2014)."Silicon Valley launches another bid to 'hack' aging, cheat death".San Jose Mercury News.RetrievedOctober 1,2014.
- ^Victoria Thorp (November 23, 2014)."The Palo Alto Prize: A 'Moonshot' at Increasing Longevity".Palo Alto Pulse. Archived fromthe originalon December 6, 2014.RetrievedDecember 8,2014.