IGHD

This article is about the human gene. For Isolated Growth Hormone Deficiency, seeGrowth hormone deficiency.

IGHD
Identifiers
Aliases	IGHD,immunoglobulin heavy constant delta
External IDs	OMIM:147170;GeneCards:IGHD;OMA:IGHD - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.33 Start 105,836,765bp End 105,845,677bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in lymph node spleen granulocyte bone marrow cells appendix blood olfactory zone of nasal mucosa salivary gland tonsil minor salivary glands n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 3495 n/a Ensembl ENSG00000211898 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.84 – 105.85 Mb n/a PubMedsearch n/a
Wikidata
View/Edit Human

Ig delta chain C regionis aproteinthat in humans is encoded by theIGHDgene.

Further reading

• Shin SU, Wei CF, Amin AR, et al. (1992). "Structural and functional properties of mouse-human chimeric IgD".Hum. Antibodies Hybridomas.3(2): 65–74.doi:10.3233/HAB-1992-3202.PMID1633267.
• Roes J, Rajewsky K (1992). "Cell autonomous expression of IgD is not essential for the maturation of conventional B cells".Int. Immunol.3(12): 1367–71.doi:10.1093/intimm/3.12.1367.PMID1838007.
• Shinoda T, Takahashi N, Takayasu T, et al. (1981)."Complete amino acid sequence of the Fc region of a human delta chain".Proc. Natl. Acad. Sci. U.S.A.78(2): 785–9.Bibcode:1981PNAS...78..785S.doi:10.1073/pnas.78.2.785.PMC319887.PMID6785754.
• Lin LC, Putnam FW (1981)."Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function".Proc. Natl. Acad. Sci. U.S.A.78(1): 504–8.Bibcode:1981PNAS...78..504L.doi:10.1073/pnas.78.1.504.PMC319082.PMID6787589.
• Putnam FW, Takahashi N, Tetaert D, et al. (1982)."Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD".Proc. Natl. Acad. Sci. U.S.A.78(10): 6168–72.doi:10.1073/pnas.78.10.6168.PMC348999.PMID6947220.
• Takayasu T, Takahashi N, Shinoda T (1981). "Amino acid sequence and location of the three glycopeptides in the Fc region of human immunoglobulin D".Biochem. Biophys. Res. Commun.97(2): 635–41.doi:10.1016/0006-291X(80)90311-3.PMID7008791.
• Takayasu T, Suzuki S, Kametani F, et al. (1982). "Amino acid sequence of galactosamine-containing glycopeptides in the hinge region of a human immunoglobulin D".Biochem. Biophys. Res. Commun.105(3): 1066–71.doi:10.1016/0006-291X(82)91078-6.PMID7092891.
• Roes J, Rajewsky K (1993)."Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells".J. Exp. Med.177(1): 45–55.doi:10.1084/jem.177.1.45.PMC2190865.PMID8418208.
• Scott IC, Halila R, Jenkins JM, et al. (1996). "Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1)".Gene.174(1): 135–43.doi:10.1016/0378-1119(96)00510-0.PMID8863740.
• Zupo S, Cutrona G, Mangiola M, Ferrarini M (2002)."Role of surface IgM and IgD on survival of the cells from B-cell chronic lymphocytic leukemia".Blood.99(6): 2277–8.doi:10.1182/blood-2001-11-0126.PMID11902141.
• Gala FA, Morrison SL (2002)."The role of constant region carbohydrate in the assembly and secretion of human IgD and IgA1".J. Biol. Chem.277(32): 29005–11.doi:10.1074/jbc.M203258200.PMID12023968.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Schamel WW, Kuppig S, Becker B, et al. (2003)."A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum".Proc. Natl. Acad. Sci. U.S.A.100(17): 9861–6.Bibcode:2003PNAS..100.9861S.doi:10.1073/pnas.1633363100.PMC187866.PMID12886015.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006)."Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry".J. Proteome Res.4(6): 2070–80.doi:10.1021/pr0502065.PMC1850943.PMID16335952.
• Lee CE, Gaëta B, Malming HR, et al. (2006). "Reconsidering the human immunoglobulin heavy-chain locus: 1. An evaluation of the expressed human IGHD gene repertoire".Immunogenetics.57(12): 917–25.doi:10.1007/s00251-005-0062-5.PMID16402215.S2CID29291806.
• Lee CE, Jackson KJ, Sewell WA, Collins AM (2007). "Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia".Leuk. Res.31(9): 1247–52.doi:10.1016/j.leukres.2006.10.013.PMID17169423.
• Samuelsson M, Hallström T, Forsgren A, Riesbeck K (2007)."Characterization of the IgD binding site of encapsulated Haemophilus influenzae serotype b".J. Immunol.178(10): 6316–9.doi:10.4049/jimmunol.178.10.6316.PMID17475860.