Isovaleramide
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| Names | |
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| Preferred IUPAC name
3-Methylbutanamide | |
| Other names
Isopentanamide
Isovaleric acid amide Isovaleric amide beta-Methylbutyramide | |
| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| ECHA InfoCard | 100.007.984 |
| EC Number |
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| KEGG | |
PubChemCID
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| UNII | |
CompTox Dashboard(EPA)
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| Properties | |
| C5H11NO | |
| Molar mass | 101.149g·mol−1 |
| Appearance | colourless solid |
| Melting point | 137 °C (279 °F; 410 K) |
| Boiling point | 226 °C (439 °F; 499 K) |
Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa).
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Isovaleramideis anorganic compoundwith the formula (CH3)2CHCH2C(O)NH2.Theamidederived fromisovaleric acid,it is a colourless solid.
Occurrence and biological activity
[edit]Isovaleramide is a constituent ofvalerian root.
In humans, it acts as a mildanxiolyticat lower doses and as a mildsedativeat higher dosages.[1]Isovaleramide has been shown to be non-cytotoxicand does not act as aCNS stimulant.It inhibits theliveralcohol dehydrogenasesand has a reportedLD50of greater than 400 mg/kg when administeredintraperitoneallyin mice.[2]
It is apositive allosteric modulatorof theGABAAreceptor,similarly to isovaleric acid. [3]
References
[edit]- ^US 5506268,Balandrin, Manuel F. & Van Wagenen, Bradford C., "Use of isovaleramide as a mild anxiolytic and sedative agent", published 1996-04-09, assigned toNPS Pharmaceuticals Inc.
- ^Taillandier, Georges; Benoit-Guyod, Jean L.; Boucherle, Andre; Broll, Madeleine; Eymard, Pierre (1975). "Dipropylacetic series. XII. Anticonvulsant branched aliphatic acids and alcohols".European Journal of Medicinal Chemistry.10(5): 453–462.
- ^Giraldo SE, Rincón J, Puebla P, Marder M, Wasowski C, Vergel N, Guerrero MF (2010)."[Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii]".Biomedica(in Spanish).30(2): 245–50.doi:10.7705/biomedica.v30i2.187.hdl:11336/18247.PMID20890571.