Isoxicam
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| Trade names | Maxicam |
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| ECHA InfoCard | 100.047.334 |
| Chemical and physical data | |
| Formula | C14H13N3O5S |
| Molar mass | 335.33g·mol−1 |
| 3D model (JSmol) | |
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Isoxicamis anonsteroidal anti-inflammatory drug(NSAID) that was taken or applied to reduceinflammationand as ananalgesicreducing pain in certain conditions. The drug was introduced in 1983 by theWarner-Lambert Company.Isoxicam is a chemical analog ofpiroxicam(Feldene) which has a pyridine ring in lieu of an isoxazole ring. In 1985 isoxicam was withdrawn from the French market, due to adverse effects, namelytoxic epidermal necrolysisresulting in death. Although these serious side effects were observed only in France, the drug was withdrawn worldwide.[1][2]
References
[edit]- ^Consolidated List of products whose consumption and/or sale have been banned, withdrawn, severely restricted or not approved by Governments,United Nations, 2003, p. 123link to 2005 ed
- ^Fung M, Thornton A, Mybeck K, Wu JH, Hornbuckle K, Muniz E (January 2001). "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999".Therapeutic Innovation & Regulatory Science.35(1): 293–317.doi:10.1177/009286150103500134.S2CID73036562.
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Key:underlineindicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;†withdrawn drugs;‡veterinary use. | |
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