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Jane Visvader

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Jane Visvader
FRSFAAFAHMS
Alma materUniversity of Adelaide
Scientific career
InstitutionsWalter and Eliza Hall Institute of Medical Research
Salk Institute

Jane VisvaderFRSFAAFAHMSis ascientistspecialising inbreast cancerresearch who works for theWalter and Eliza Hall InstituteinMelbourne,Australia.She is the joint head of the Breast Cancer Laboratory with Geoff Lindeman.[1]

Education

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Visvader holds a PhD inBiochemistryfrom theUniversity of Adelaidehaving studied structure and function of citrus exocortis viroid[2]

Career and research

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After her PhD[3]in the Department of Biochemistry at the University of Adelaide, she was apostdoctoral researcherwithInder Verma(Salk Institute,San Diego) andJerry Adams(Walter and Eliza Hall Institute (WEHI)).[4]She worked at the Children's Hospital/Harvard Medical SchoolinBostonbefore returning to Victoria in 1997 to establish a Breast Cancer Laboratory at WEHI.[5]

Visvader has published work investigating the role of cells of origin in cancer[6]and in particular focuses on the role of stem cells,[7][8]which she believes may be a key to understanding breast cancer.[9]

Visvader is a board member of the Cancer Council Victoria, Medical & Scientific Committee.[10]

Patents

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Visvader is a named inventor on fivepatentsrelating to cancer research focused onstem cellisolation and diagnostics.[11]

  • Method Of Cell Isolation, Application number: 20080038230
  • Differentiation and/or proliferation modulating agents and uses therefor, Application number: 20060166917
  • Novel phosphoprotein, Application number: 20060148032
  • Method of diagnosis and treatment and agents useful for same, Application number: 20050048528
  • Differentiation and/or proliferation modulating agents and uses therefor, Application number: 20030175971

Awardsa and recognition

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Selected publications

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  • Rios, AC; Fu, NY; Lindeman, GJ; Visvader, JE (20 February 2014). "In situ identification of bipotent stem cells in the mammary gland".Nature.506(7488): 322–7.Bibcode:2014Natur.506..322R.doi:10.1038/nature12948.PMID24463516.
  • Nolan E, Vaillant F, Branstetter D, Pal B, Giner G, Whitehead L, Lok SW, Mann GB, Rohrbach K, Huang LY, Soriano R, Smyth GK, Dougall WC,Visvader JE*and Lindeman GJ*. (2016)RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.Nat Med. 2016 Jun 20. doi: 10.1038/nm.4118. PMID: 27322743 equal senior author
  • Fu NY, Rios AC, Pal B, Law C, Jamieson P, Liu R, Vaillant F, Jackling F, Liu KH, Smyth GK, Lindeman GJ, Ritchie ME, andVisvader JE.Identification of quiescent and spatially-restricted mammary stem cells that are hormone responsive.Nature Cell Biol. 2017 19(3):164-176 PMID: 28192422
  • Rios AC, Capaldo BD, Vaillant F, Pal B, van Ineveld R, Dawson CA, Chen Y, Nolan E, Fu NY; 3DTCLSM Group, Jackling FC, Devi S, Clouston D, Whitehead L, Smyth GK, Mueller SN, Lindeman GJ,Visvader JE.Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging.Cancer Cell. 2019 35(4), 618-632 PMID: 31185217
  • Dawson CA, Pal B, Vaillant F, Gandolfo LC, Liu Z, Bleriot C, Ginhoux F, Smyth GK, Lindeman GJ, Mueller SN, Rios AC,Visvader JE.Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling.Nature Cell Biol. 2020 22(5), 546-558. PMID: 32341550
  • Pal B, Chen Y, Vaillant F, Capaldo BD, Joyce R, Song X, Bryant VL, Penington JS, Di Stephano L, Tubau Ribera N, Wilcox S, Mann, GB, kConFab, Papenfuss AT, Lindeman GJ, Smyth GK*,Visvader JE*.A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast.EMBO J. 2021 40(11): e107333 PMID: 33950524 *equal senior authors

References

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  1. ^"Professor Jane Visvader".Retrieved14 August2014.
  2. ^"Structure and function of citrus exocortis viroid / by Jane Ellen Visvader. - Version details - Trove".Trove.nla.gov.au. 28 December 2006.Retrieved14 August2014.
  3. ^"Professor Jane Visvader".
  4. ^"News | Royal Society of Victoria | Promoting Science and Science Education".Royalsocietyvictoria.org.au.Retrieved14 August2014.
  5. ^"News | Royal Society of Victoria | Promoting Science and Science Education".Royalsocietyvictoria.org.au.Retrieved14 August2014.
  6. ^Visvader, Jane E. (2011). "Cells of origin in cancer".Nature.469(7330): 314–322.Bibcode:2011Natur.469..314V.doi:10.1038/nature09781.PMID21248838.S2CID4418009.
  7. ^Rios, Anne C.; Fu, Nai Yang; Lindeman, Geoffrey J.; Visvader, Jane E. (2014). "In situ identification of bipotent stem cells in the mammary gland".Nature.506(7488): 322–327.Bibcode:2014Natur.506..322R.doi:10.1038/nature12948.PMID24463516.S2CID205237171.
  8. ^Visvader, Jane E.; Lindeman, Geoffrey J. (2012)."Cancer Stem Cells: Current Status and Evolving Complexities".Cell Stem Cell.10(6): 717–728.doi:10.1016/j.stem.2012.05.007.PMID22704512.
  9. ^Giovanni Valenti (11 January 2012)."Interview with Jane Visvader: stem cells in the breast | Europe's stem cell hub".Nature.439(7072): 84–88.doi:10.1038/nature04372.PMID16397499.S2CID2662840.Retrieved14 August2014.
  10. ^https:// cancervic.org.au/about/governance/executive-committee[bare URL]
  11. ^"Patents by Inventor Jane Visvader - Justia Patents Database".Patents.justia.Retrieved14 August2014.
  12. ^"GSK Alumni Members".Retrieved9 February2021.
  13. ^"Fellowship list - Australian Academy of Science".Science.org.au.Retrieved14 August2014.
  14. ^"News | Royal Society of Victoria | Promoting Science and Science Education".Royalsocietyvictoria.org.au.Retrieved14 August2014.
  15. ^"Top NHMRC research recognised".Retrieved9 February2021.
  16. ^"THE 2016 LEMBERG MEDAL: JANE VISVADER".Retrieved9 February2021.
  17. ^"AAHMS announces its second scientific meeting and induction of new fellows"(PDF).Australian Academy of Health and Medical Sciences.Retrieved14 October2016.
  18. ^"Professor Jane Visvader&Professor Geoffrey Lindeman 2017 Victoria Prize for Science & Innovation".Retrieved9 February2021.
  19. ^"Jane Visvader".Royal Society.Retrieved20 September2020.
  20. ^"Prof Jane Visvader".
  21. ^"Prof Jane Visvader".
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