Jean-François Borel

Jean-François Borel(born 4 July 1933 inAntwerp,Belgium) is a Belgianmicrobiologistandimmunologistwho is considered one of the discoverers ofcyclosporin.

Early life

Borel studied at theUniversity of Antwerpand theETH Zurich,where he received his doctorate in immunological genetics in 1964. Afterwards he was at the Swiss Research Institute of Medicine. From 1970 he was in the research laboratories ofSandozinBasel.

Discovery of cyclosporin

In 1972, Borel was involved in the discovery of theimmunosuppressiveeffects of cyclosporin (Sandoz called Sandimmun), which was isolated by Sandoz in 1971 from a fungus that a Sandoz employee brought back from vacation in Norway. The screening program at Sandoz was previously developed by K. Saameli (and Stähelin) and the immunological testing procedures of S. Lazary. Initially, use as an antibiotic was considered. When it was realized that the substance had onlyT-cellsand therefore had potential in transplantation medicine, Borel aroused much attention in 1976 at a congress in London. In the practice of organ transplantation, the new drug was tested in 1977 by the British surgeonRoy Yorke Calne.

In 1983, Borel became vice president of the pharmaceutical division of Sandoz (laterNovartis). Since 1981 he was Professor of Immunopharmacology at theUniversity of Bern.

Also involved in the discovery and development wasHartmann Stähelin,head of the Pharmacology Department at Sandoz, which included the Immunology Department, and later there was a dispute over their respective shares in the discovery.

Awards

• 1984:Cloëtta Prize
• 1985:J. Allyn Taylor International Prize in Medicine
• 1986:Gairdner Foundation International Award
• 1987:Paul Ehrlich and Ludwig Darmstaedter Prize
• 1993:InBev-Baillet Latour Health Prize
• 1991 he became an honorary doctor in Basel.

See also

Organ transplantation