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Joseph L. Goldstein

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For other people named Joseph Goldstein, seeJoseph Goldstein (disambiguation).
Joseph L. Goldstein
Born
Joseph Leonard Goldstein[2]

(1940-04-18)April 18, 1940(age 84)
Kingstree, South Carolina
Alma mater
Known forcholesterol
Awards
Scientific career
Fieldsbiochemistry
InstitutionsUniversity of Texas Southwestern Medical Center
Websiteprofiles.utsouthwestern.edu/profile/12645/joseph-goldstein.html

Joseph Leonard GoldsteinForMemRS(born April 18, 1940) is an Americanbiochemist.He received theNobel Prize in Physiology or Medicinein 1985, along with fellowUniversity of Texas Southwesternresearcher,Michael Brown,for their studies regardingcholesterol.[3]They discovered that human cells havelow-density lipoprotein(LDL) receptors that removecholesterolfrom the blood and that whenLDL receptorsare not present in sufficient numbers, individuals develophypercholesterolemiaand become at risk for cholesterol related diseases, notablycoronary heart disease.[4]Their studies led to the development ofstatindrugs.[3]

Life and career[edit]

Goldstein was born in Kingstree, South Carolina, the son of Fannie (Alpert) and Isadore E. Goldstein, who owned a clothing store. His family isJewish.[5]Goldstein received his BSci fromWashington and Lee Universityin 1962, and his MD from the University of TexasSouthwestern Medical Schoolin 1966.[3]Upon completion of hisresidency,Goldstein moved to theNational Institutes of Health(NIH) inBethesda, Maryland,where he worked inbiochemical genetics.[6]In 1972, Goldstein relocated back to the Southwestern Medical Center, accepting a post as the head of the Division of Medical Genetics.[6]

At the Southwestern Medical Center Goldstein collaborated extensively withMichael Brown,a fellow researcher at the center who had also worked at the NIH.[6]From 1973 to 1985, Goldstein and Brown together published over one hundred major papers.[7]They are both listed inThomson Reuters’ index of highly cited authors.[8]Frequently mentioned as a candidate for nationally prominent positions in scientific administration, Goldstein, like his colleague Michael Brown, chose to continue hands-on research.[9][10]

In 1993, their postdoctoral trainees,Wang XiaodongandMichael Briggs,purified theSterol Regulatory Element-Binding Proteins(SREBPs), a family of membrane-bound transcription factors. Since 1993, Goldstein, Brown, and their colleagues have described the unexpectedly complex machinery that proteolytically releases the SREBPs from membranes, thus allowing their migration to the nucleus where they activate all the genes involved in the synthesis of cholesterol and fatty acids. The machinery for generating active SREBPs is tightly regulated by a negative feedback mechanism, which explains how cells maintain the necessary levels of fats and cholesterol in the face of varying environmental circumstances.[11][12][13]

Goldstein is chair, Molecular Genetics atUniversity of Texas Southwestern Medical Center.Together, Goldstein and Brown lead a research team that typically includes a dozen doctoral and postdoctoral trainees. They have trained over 145 graduate students and postdoctoral fellows, and six of their former postdoctoral fellows (Thomas C. Südhof,Wang Xiaodong, Helen H. Hobbs, David W. Russell, Monty Krieger, and Russell DeBose-Boyd) have been elected to the U.S.National Academy of Sciences.[14]Former postdoctoral fellowThomas C. Südhofreceived the 2013 Nobel Prize in Medicine or Physiology[15]andHelen H. Hobbsreceived the 2015Breakthrough Prize in Life Sciences.[16][17]

In 1988 Goldstein received aNational Medal of Sciencein the field of molecular genetics,[18]and in 2003 Goldstein and Brown won theAlbany Medical Center Prize in Medicine and Biomedical Researchin recognition for their further work in understanding cholesterol and also the discovery of aninsulin-sensitive regulator, which potentially could be used to develop treatments fordiabetes mellitus.[19]Goldstein is a member of the U.S.National Academy of Sciences[20]and theInstitute of Medicine[21]and he was elected aForeign Member of the Royal Society (ForMemRS) in 1991.[1]

Goldstein was appointed as chairman of theAlbert Lasker Medical Research Awardsjury in 1995,[22]and was a recipient of the award ten years earlier.[23]Since 2000, Goldstein has authored a series of essays on the deep relationship between art and science that appear in the annualNature Medicinesupplement that accompanies the Lasker Awards.[24]

Among his professional activities, Goldstein is a member of the Board of Trustees of TheHoward Hughes Medical Institute[25]and of TheRockefeller University,where he was elected as a Life Trustee in 2015.[26]He also serves as chairman of the Board of Scientific Counselors of theBroad Institute,[27]and is a member of the Board of Directors ofRegeneron Pharmaceuticals,Inc.[28]He previously served on The Board of Scientific Governors of theScripps Research Institute,a nonprofit institute that conducts biomedical research.[29]

Awards[edit]

Joseph L. Goldstein has been awarded the following:

Research papers[edit]

Essays on "The Art of Science"[edit]

Since 2000, Goldstein has authored a series of essays considering science as a creative pursuit, and explores the links between art and science. The essays have appeared in the journals Nature Medicine, Cell, and most recently, PNAS. They coincide with the annual announcement of the Lasker Awards, with which Goldstein is affiliated in the capacity of jury chairman. A collection of Goldstein's essays titledThe Art of Sciencewas published in 2023.

See also[edit]

References[edit]

  1. ^abc"Professor Joseph L Goldstein ForMemRS".London:Royal Society.Archived fromthe originalon 2015-11-04.
  2. ^Joseph L. Goldstein – Biographical.Nobelprize.org (1940-04-18). Retrieved on 2013-10-08.
  3. ^abcBadge, Peter (2007) "Joseph Goldstein".Nobel Faces.John Wiley & Sons.ISBN9783527406784.p 300.
  4. ^Encyclopedia of Global Health, Volume 1by Luca Prono, edited by Yawei Zhang
  5. ^"Jewish Nobel Prize Winners in Medicine".jinfo.org.Retrieved2023-03-30.
  6. ^abcRaju, T. N. (2000). "The Nobel Chronicles".The Lancet.355(9201): 416.doi:10.1016/S0140-6736(05)74047-2.PMID10665595.S2CID54420330.
  7. ^The Cholesterol Wars: The Skeptics Vs. the Preponderance of EvidenceBy Daniel Steinberg
  8. ^"Highly Cited Researchers - The Most Influential Scientific Minds".highlycited.Retrieved23 March2018.
  9. ^Culliton BJ. (1989 Sep 29). "Baltimore to succeed Lederberg?.".Science.Retrieved December 6, 2012. "Nobel laureate Joshua Lederberg (1958) is set to retire as president of Rockefeller University in January... Things might not have grown so tense had the man who apparently was at the top of the list said" Yes. "But Nobel laureate Joseph Goldstein (1985), who is still very active in the laboratory at the University of Texas at Dallas, was not ready to give up his work on the molecular genetics of blood lipids."
  10. ^Journal of Clinical Investigation InterviewArchived2013-07-19 at theWayback MachineFilm Annex
  11. ^Wang X, Sato R, Brown MS, Hua X, Goldstein JL. (April 8, 1994). "SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis.".Cell.Retrieved November 29, 2012.
  12. ^Wang X, Briggs MR, Hua X, Yokoyama C, Goldstein JL, Brown MS. (June 5, 1993). "Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization.".The Journal of Biological Chemistry.Retrieved November 29, 2012.
  13. ^Espenshade, Peter J. (2006). "SREBPs: sterolregulated transcription factors.".Journal of Cell Science.Retrieved December 6, 2012.
  14. ^"Department of Molecular Genetics Overview.".Retrieved December 6, 2012.
  15. ^"Nobel Prize: Thomas C. Südhof - Facts.".Retrieved November 26, 2013.
  16. ^"Laureates".breakthroughprize.org.Breakthrough Prize. 2015.Retrieved2015-12-18.
  17. ^"Breakthrough Prizes Give Top Scientists the Rock Star Treatment".The New York Times.2015-11-08.Retrieved2015-12-18.
  18. ^Encyclopædia Britannica Almanac 2008p. 114
  19. ^UT Southwestern researchers receive top medicine prizeDallas Business Journal, Date: Wednesday, April 30, 2003
  20. ^Member Directory: Joseph L. Goldstein.National Academy of Sciences. Retrieved on 2014-10-16.
  21. ^Directory: IOM Member - Joseph L. Goldstein, M.D.Archived2010-07-23 at theWayback Machine.Institute of Medicine. Retrieved on 2014-10-16.
  22. ^Goodman, Billy (October 16, 1995). "Lasker Laureates Make Up Impressive Biomedical Roster".The Scientist.Retrieved October 24, 2012.
  23. ^"1985 Winners: Albert Lasker Basic Medical Research AwardArchived2015-09-13 at theWayback Machine",Lasker Foundation.Retrieved October 25, 2012.
  24. ^"Nature Medicine" essays: The Art of Science.Laskerfoundation.org (2007-09-16). Retrieved on 2013-10-08.
  25. ^"Trustees".hhmi.org.Retrieved23 March2018.
  26. ^The Rockefeller University Board of Trustees and Corporate Officers.Rockefeller.edu. Retrieved on 2013-10-08.
  27. ^Board of Scientific Counselors.Broad Institute. Retrieved on 2014-10-16.
  28. ^"Regeneron Board of Directors".regeneron.Regeneron. 2015.Retrieved2015-12-18.
  29. ^The Scripps Research Institute Board of Governors.Scripps.edu (2013-10-04). Retrieved on 2013-10-08.
  30. ^Earl and Thressa Stadtman Distinguished Scientist AwardArchived2019-05-07 at theWayback MachineThe American Society for Biochemistry and Molecular Biology (ASBMB)
  31. ^University of Texas Southwestern Medical Center Leaders to Receive Research!America Advocacy AwardArchived2013-02-16 at theWayback MachineResearch America, Date: March 21, 2007
  32. ^Recipients of the Woodrow Wilson Award for Public ServiceArchived2013-10-08 at theWayback MachineWilson Center
  33. ^Herbert Tabor Research AwardArchived2012-06-04 at theWayback MachineThe American Society for Biochemistry and Molecular Biology (ASBMB)
  34. ^The Albany Prize in Medicine and Biomedical Research 2003 RecipientsAlbany Medical College
  35. ^Presentation of the Kober Medal to Joseph L. Goldstein and Michael S. BrownThe Journal of Clinical Investigation
  36. ^Warren Alpert Foundation Award RecipientsArchived2012-04-10 at theWayback MachineWarren Alpert Foundation
  37. ^The President's National Medal of Science: Recipient DetailsNational Science Foundation
  38. ^"APS Member History".
  39. ^"Golden Plate Awardees of the American Academy of Achievement".achievement.org.American Academy of Achievement.
  40. ^The Nobel Prize in Physiology or Medicine 1985The Official Website of the Nobel Prize
  41. ^Albert Lasker Basic Medical Research Award 1985Archived2015-09-13 at theWayback MachineLasker Foundation
  42. ^William Allan Award Past RecipientsArchived2014-10-03 at theWayback MachineThe American Society of Human Genetics (ASHG)
  43. ^The Louisa Gross Horwitz Prize for Biology or BiochemistryColumbia University Medical Center
  44. ^Recipient of the Canada Gairdner International Award, 1981Gairdner Foundation
  45. ^Archive indexat theWayback Machine
  46. ^"Joseph Goldstein".nasonline.org.Retrieved23 March2018.
  47. ^Richard Lounsbery AwardNational Academy of Sciences
  48. ^The Passano Awards 1945–2011The Passano Foundation
  49. ^The Pfizer AwardArchived2021-07-31 at theWayback MachineACS Division of Biological Chemistry

External links[edit]

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