KCNC2
Potassium voltage-gated channel subfamily C member 2is aproteinthat in humans is encoded by theKCNC2gene.[5][6]Theproteinencoded by this gene is avoltage-gated potassium channelsubunit (Kv3.2).[7]
Expression pattern
[edit]Kv3.1 and Kv3.2 channels are prominently expressed inneuronsthat fire at high frequency. Kv3.2 channels are prominently expressed in brain (fast-spiking GABAergic interneurons of theneocortex,hippocampus,andcaudate nucleus;terminal fields of thalamocortical projections), and inretinal ganglion cells.[8][9][7]
Physiological role
[edit]Kv3.1/Kv3.2 conductance is necessary and kinetically optimized for high-frequency action potential generation.[9][10]Sometimes in heteromeric complexes with Kv3.1; important for the high-frequency firing of fast spiking GABAergic interneurons and retinal ganglion cells; and GABA release via regulation of action potential duration in presynaptic terminals.[7][8]
Pharmacological properties
[edit]Kv3.2 currents in heterologous systems are highly sensitive to externaltetraethylammonium(TEA) or4-aminopyridine(4-AP) (IC50values are 0.1 mM for both of the drugs).[7][9]This can be useful in identifying native channels.[9]
Transcript variants
[edit]There are fourtranscript variantsof Kv3.2 gene: Kv3.2a, Kv3.2b, Kv3.2c, Kv3.2d. Kv3.2 isoforms differ only in theirC-terminalsequence.[11]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000166006–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000035681–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Haas M, Ward DC, Lee J, Roses AD, Clarke V, D'Eustachio P, Lau D, Vega-Saenz de Miera E, Rudy B (Mar 1994). "Localization of Shaw-related K+ channel genes on mouse and human chromosomes".Mamm Genome.4(12): 711–5.doi:10.1007/BF00357794.PMID8111118.S2CID24121259.
- ^Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels".Pharmacol Rev.57(4): 473–508.doi:10.1124/pr.57.4.10.PMID16382104.S2CID219195192.
- ^abcdGutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X (December 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels".Pharmacol. Rev.57(4): 473–508.doi:10.1124/pr.57.4.10.PMID16382104.S2CID219195192.
- ^abKolodin YO (2008-04-27)."Ionic conductances underlying excitability in tonically firing retinal ganglion cells of adult rat".Retrieved2008-10-20.
- ^abcdRudy B, McBain CJ (September 2001). "Kv3 channels: voltage-gated K+channels designed for high-frequency repetitive firing ".Trends in Neurosciences.24(9): 517–26.doi:10.1016/S0166-2236(00)01892-0.PMID11506885.S2CID36100588.
- ^Lien CC, Jonas P (March 2003)."Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons ".Journal of Neuroscience.23(6): 2058–68.doi:10.1523/JNEUROSCI.23-06-02058.2003.PMC6742035.PMID12657664.
- ^Rudy B, Chow A, Lau D, Amarillo Y, Ozaita A, Saganich M, Moreno H, Nadal MS, Hernandez-Pineda R, Hernandez-Cruz A, Erisir A, Leonard C, Vega-Saenz de Miera E (April 1999)."Contributions of Kv3 channels to neuronal excitability ".Annals of the New York Academy of Sciences.868(1 MOLECULAR AND): 304–43.Bibcode:1999NYASA.868..304R.doi:10.1111/j.1749-6632.1999.tb11295.x.PMID10414303.S2CID25289187.
External links
[edit]- Kv3.2+Potassium+Channelat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
- KCNC2+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)