KCNK10

KCNK10
Available structures
PDB	Human UniProt search:PDBeRCSB
List of PDB id codes
	4BW5,4XDJ,4XDK,4XDL
Identifiers
Aliases	KCNK10,K2p10.1, PPP1R97, TREK-2, TREK2, potassium two pore domain channel subfamily K member 10
External IDs	OMIM:605873;MGI:1919508;HomoloGene:11321;GeneCards:KCNK10;OMA:KCNK10 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	88,326,907bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	98,544,569bp
RNA expressionpattern
	Top expressed in
	cerebellar vermis; ; pons; ; ventricular zone; ; Brodmann area 23; ; superior vestibular nucleus; ; ventral tegmental area; ; jejunal mucosa; ; dorsal motor nucleus of vagus nerve; ; parietal lobe; ; inferior olivary nucleus;
	Top expressed in
	ventricular zone; ; spermatocyte; ; lumbar spinal ganglion; ; ganglionic eminence; ; medial ganglionic eminence; ; cerebellar cortex; ; neural tube; ; trigeminal ganglion; ; mesencephalon; ; lobe of cerebellum;
	More reference expression data
	n/a
Gene ontology
Molecular function	potassium channel activity; voltage-gated ion channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; memory; ion transport; signal transduction; stabilization of membrane potential; potassium ion transmembrane transport;
	Sources:Amigo/QuickGO
Orthologs
	54207
	72258
	ENSG00000100433
	ENSMUSG00000033854
	P57789
	n/a
	NM_021161; NM_138317; NM_138318
	NM_029911; NM_001316664; NM_001316665; NM_001316666
	NP_066984; NP_612190; NP_612191
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel, subfamily K, member 10,also known asKCNK10is a humangene.Theproteinencoded by this gene, K_2P10.1, is apotassium channelcontaining two pore-forming P domains.^[5]^[6]^[7]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000100433–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000033854–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lesage F, Terrenoire C, Romey G, Lazdunski M (September 2000)."Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors".The Journal of Biological Chemistry.275(37): 28398–405.doi:10.1074/jbc.M002822200.PMID 10880510.
^Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005)."International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels".Pharmacological Reviews.57(4): 527–40.doi:10.1124/pr.57.4.12.PMID 16382106.S2CID 7356601.
^Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP (March 2015)."K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac".Science.347(6227): 1256–9.Bibcode:2015Sci...347.1256D.doi:10.1126/science.1261512.PMC6034649.PMID 25766236.

External links

KCNK10+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)

Thismembrane protein–related article is astub.You can help Wikipedia byexpanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100433–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033854–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10880510-5] Lesage F, Terrenoire C, Romey G, Lazdunski M (September 2000)."Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors".The Journal of Biological Chemistry.275(37): 28398–405.doi:10.1074/jbc.M002822200.PMID 10880510.

[pmid16382106-6] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005)."International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels".Pharmacological Reviews.57(4): 527–40.doi:10.1124/pr.57.4.12.PMID 16382106.S2CID 7356601.

[pmid25766236-7] Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP (March 2015)."K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac".Science.347(6227): 1256–9.Bibcode:2015Sci...347.1256D.doi:10.1126/science.1261512.PMC6034649.PMID 25766236.

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KCNK10

See also

References

Further reading

External links