KCNK13

KCNK13
Identifiers
Aliases	KCNK13,K2p13.1, THIK-1, THIK1, potassium two pore domain channel subfamily K member 13
External IDs	OMIM:607367;MGI:2384976;HomoloGene:69351;GeneCards:KCNK13;OMA:KCNK13 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q32.11 Start 90,061,994bp End 90,185,853bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 E Start 99,930,758bp End 100,028,941bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in right testis left testis monocyte granulocyte appendix human kidney right auricle left lobe of thyroid gland prefrontal cortex right lobe of thyroid gland Top expressed in secondary oocyte stroma of bone marrow primary oocyte zygote embryo left lung lobe superior frontal gyrus deep cerebellar nuclei dentate gyrus of hippocampal formation granule cell primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function potassium channel activity voltage-gated ion channel activity potassium ion leak channel activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport stabilization of membrane potential potassium ion transmembrane transport Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 56659 217826 Ensembl ENSG00000152315 ENSMUSG00000045404 UniProt Q9HB14 Q8R1P5 RefSeq (mRNA) NM_022054 NM_001164426 NM_001164427 NM_146037 RefSeq (protein) NP_071337 NP_001157898 NP_001157899 NP_666149 Location (UCSC) Chr 14: 90.06 – 90.19 Mb Chr 12: 99.93 – 100.03 Mb PubMedsearch
Wikidata
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Potassium channel, subfamily K, member 13,also known asKCNK13is a humangene.Theproteinencoded by this gene, K_2P13.1 is apotassium channelcontaining two pore-forming P domains.

See also

• Tandem pore domain potassium channel

Further reading

• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Fearon IM, Campanucci VA, Brown ST, Hudasek K, o'Kelly IM, Nurse CA (2006)."Acute Hypoxic Regulation of Recombinant THIK-1 Stably Expressed in HEK293 Cells".The Arterial Chemoreceptors.ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. Vol. 580. pp.203–8, discussion 351–9.doi:10.1007/0-387-31311-7_31.ISBN978-0-387-31310-8.PMID16683720.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001)."Potassium leak channels and the KCNK family of two-P-domain subunits".Nat. Rev. Neurosci.2(3): 175–84.doi:10.1038/35058574.PMID11256078.S2CID9682396.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Theilig F, Goranova I, Hirsch JR, Wieske M, ÜNsal S, Bachmann S, Veh RW, Derst C (2008)."Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney".Cell. Physiol. Biochem.21(1–3): 63–74.doi:10.1159/000113748.PMID18209473.
• Gierten J, Ficker E, Bloehs R, Schlömer K, Kathöfer S, Scholz E, Zitron E, Kiesecker C, Bauer A (2008)."Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein".Br. J. Pharmacol.154(8): 1680–90.doi:10.1038/bjp.2008.213.PMC2518462.PMID18516069.

External links

• KCNK13+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)