KCNK18

KCNK18
Identifiers
Aliases	KCNK18,K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK, potassium two pore domain channel subfamily K member 18
External IDs	OMIM:613655;MGI:2685627;HomoloGene:133808;GeneCards:KCNK18;OMA:KCNK18 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	117,210,299bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	59,225,806bp
RNA expressionpattern
	Top expressed in
	nucleus accumbens; ; caudate nucleus; ; prefrontal cortex; ; hypothalamus; ; renal cortex; ; anterior cingulate cortex;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; embryo; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium-activated potassium channel activity; outward rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	potassium ion transport; cellular response to pH; ion transport; potassium ion transmembrane transport; stabilization of membrane potential; potassium ion export across plasma membrane;
	Sources:Amigo/QuickGO
Orthologs
	338567
	332396
	ENSG00000186795
	ENSMUSG00000040901
	Q7Z418
	Q6VV64
	NM_181840
	NM_207261
	NP_862823
	NP_997144
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 18(KCNK18), also known asTWIK-related spinal cord potassium channel(TRESK) orK_2P18.1is aproteinthat in humans is encoded by theKCNK18gene.K_2P18.1 is apotassium channelcontaining two pore-forming P domains.^[5]

A flaw in this gene could help triggermigraineheadaches. If the gene does not work properly, environmental factors can more easily trigger pain centres in the brain and cause a severe headache.^[6]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000186795–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000040901–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005)."International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels".Pharmacol. Rev.57(4): 527–40.doi:10.1124/pr.57.4.12.PMID 16382106.S2CID 7356601.
^
Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, Pereira-Monteiro JM, Griffiths LR, Tucker SJ, Ebers G, Rouleau GA (September 2010). "A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura".Nature Medicine.16(10): 1157–1160.doi:10.1038/nm.2216.PMID 20871611.S2CID 205387180.
- "Migraine cause 'identified' as genetic defect".BBC News.2010-09-27.

External links

KCNK18+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)

Thismembrane protein–related article is astub.You can help Wikipedia byexpanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186795–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040901–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16382106-5] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005)."International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels".Pharmacol. Rev.57(4): 527–40.doi:10.1124/pr.57.4.12.PMID 16382106.S2CID 7356601.

[Lafrenière_2010-6] Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, Pereira-Monteiro JM, Griffiths LR, Tucker SJ, Ebers G, Rouleau GA (September 2010). "A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura".Nature Medicine.16(10): 1157–1160.doi:10.1038/nm.2216.PMID 20871611.S2CID 205387180.
"Migraine cause 'identified' as genetic defect".BBC News.2010-09-27.

[7] "Migraine cause 'identified' as genetic defect".BBC News.2010-09-27.

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KCNK18

See also

References

Further reading

External links