KCNMB4

KCNMB4
Identifiers
Aliases	KCNMB4,potassium calcium-activated channel subfamily M regulatory beta subunit 4
External IDs	OMIM:605223;MGI:1913272;HomoloGene:8721;GeneCards:KCNMB4;OMA:KCNMB4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	70,434,292bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	116,309,783bp
RNA expressionpattern
	Top expressed in
	endothelial cell; ; postcentral gyrus; ; entorhinal cortex; ; hippocampus proper; ; corpus callosum; ; superior frontal gyrus; ; middle temporal gyrus; ; lateral nuclear group of thalamus; ; external globus pallidus; ; prefrontal cortex;
	Top expressed in
	primary motor cortex; ; lobe of cerebellum; ; cingulate gyrus; ; facial motor nucleus; ; cerebellar vermis; ; globus pallidus; ; medial dorsal nucleus; ; spermatocyte; ; prefrontal cortex; ; habenula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; calcium-activated potassium channel activity; potassium channel regulator activity;
Cellular component	integral component of membrane; integral component of plasma membrane; plasma membrane; voltage-gated potassium channel complex; membrane;
Biological process	ion transport; action potential; neuronal action potential; regulation of vasoconstriction; chemical synaptic transmission; detection of calcium ion; potassium ion transport; regulation of neurotransmitter secretion; potassium ion transmembrane transport;
	Sources:Amigo/QuickGO
Orthologs
	27345
	58802
	ENSG00000135643
	ENSMUSG00000054934
	Q86W47
	Q9JIN6
	NM_014505
	NM_021452
	NP_055320
	NP_067427
	Wikidata
View/Edit Human	View/Edit Mouse

Calcium-activated potassium channel subunit beta-4is aproteinthat in humans is encoded by theKCNMB4gene.^[5]^[6]^[7]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming Alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.^[7]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000135643–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000054934–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Brenner R, Jegla TJ, Wickenden A, Liu Y, Aldrich RW (Apr 2000)."Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4".J Biol Chem.275(9): 6453–61.doi:10.1074/jbc.275.9.6453.PMID 10692449.
^Behrens R, Nolting A, Reimann F, Schwarz M, Waldschutz R, Pongs O (Jul 2000). "hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family".FEBS Lett.474(1): 99–106.Bibcode:2000FEBSL.474...99B.doi:10.1016/S0014-5793(00)01584-2.PMID 10828459.S2CID 32791798.
^^a ^b"Entrez Gene: KCNMB4 potassium large conductance calcium-activated channel, subfamily M, beta member 4".

Orio P, Rojas P, Ferreira G, Latorre R (2002). "New disguises for an old channel: MaxiK channel beta-subunits".News Physiol. Sci.17(4): 156–61.doi:10.1152/nips.01387.2002.hdl:10533/173696.PMID 12136044.
Liu QH, Williams DA, McManus C, et al. (2000)."HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation".Proc. Natl. Acad. Sci. U.S.A.97(9): 4832–7.Bibcode:2000PNAS...97.4832L.doi:10.1073/pnas.090521697.PMC18318.PMID 10758170.
Meera P, Wallner M, Toro L (2000)."A neuronal β subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin".Proc. Natl. Acad. Sci. U.S.A.97(10): 5562–7.Bibcode:2000PNAS...97.5562M.doi:10.1073/pnas.100118597.PMC25868.PMID 10792058.
Weiger TM, Holmqvist MH, Levitan IB, et al. (2000)."A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels".J. Neurosci.20(10): 3563–70.doi:10.1523/JNEUROSCI.20-10-03563.2000.PMC6772688.PMID 10804197.
Jin P, Weiger TM, Wu Y, Levitan IB (2002)."Phosphorylation-dependent functional coupling of hSlo calcium-dependent potassium channel and its hbeta 4 subunit".J. Biol. Chem.277(12): 10014–20.doi:10.1074/jbc.M107682200.PMID 11790768.
Jin P, Weiger TM, Levitan IB (2003)."Reciprocal modulation between the Alpha and beta 4 subunits of hSlo calcium-dependent potassium channels".J. Biol. Chem.277(46): 43724–9.doi:10.1074/jbc.M205795200.PMID 12223479.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID 15489334.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135643–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054934–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10692449-5] Brenner R, Jegla TJ, Wickenden A, Liu Y, Aldrich RW (Apr 2000)."Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4".J Biol Chem.275(9): 6453–61.doi:10.1074/jbc.275.9.6453.PMID 10692449.

[pmid10828459-6] Behrens R, Nolting A, Reimann F, Schwarz M, Waldschutz R, Pongs O (Jul 2000). "hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family".FEBS Lett.474(1): 99–106.Bibcode:2000FEBSL.474...99B.doi:10.1016/S0014-5793(00)01584-2.PMID 10828459.S2CID 32791798.

[entrez-7] "Entrez Gene: KCNMB4 potassium large conductance calcium-activated channel, subfamily M, beta member 4".

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KCNMB4

See also

References

Further reading