Krueppel-like factor 12is aproteinthat in humans is encoded by theKLF12gene.[5][6]
Activator protein-2 Alpha (AP-2 Alpha ) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 Alpha gene by binding to a specific site in the AP-2 Alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)".Genomics.63(3): 384–90.doi:10.1006/geno.1999.6084.PMID10704285.
Zhu CH, Huang Y, Broman MT, Domann FE (2001). "Expression of AP-2 Alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 Alpha promoter".Biochim. Biophys. Acta.1519(1–2): 85–91.doi:10.1016/s0167-4781(01)00227-5.PMID11406275.
Chen C, Brabham WW, Stultz BG, et al. (2001). "Defining a common region of deletion at 13q21 in human cancers".Genes Chromosomes Cancer.31(4): 333–44.doi:10.1002/gcc.1152.PMID11433524.S2CID42200056.
Suda S, Rai T, Sohara E, et al. (2006). "Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter".Biochem. Biophys. Res. Commun.344(1): 246–52.doi:10.1016/j.bbrc.2006.03.138.PMID16615998.