Lipomatosis
| Lipomatosis | |
|---|---|
 | |
| Mediastinal lipomatosis | |
| Specialty | Endocrinology |
Lipomatosisis believed to be anautosomal dominantcondition in which multiplelipomasare present on the body. Many discrete, encapsulated lipomas form on the trunk and extremities, with relatively few on the head and shoulders.[1]In 1993, a genetic polymorphism within lipomas was localized to chromosome12q15,where theHMGICgene encodes the high-mobility-group protein isoform I-C.[2]This is one of the most commonly found mutations in solitary lipomatous tumors but lipomas often have multiple mutations. Reciprocal translocations involving chromosomes 12q13 and 12q14 have also been observed within.[3][4][5]
Although this condition is benign, it can sometimes be very painful depending on location of the lipomas. Some patients who are concerned with cosmetics seek removal of individual lipomas. Removal can include simple excision, endoscopic removal, or liposuction.[1]
Other entities which are accompanied by multiple lipomas includeProteus syndrome,Cowden syndromeand related disorders due toPTEN genemutations,benign symmetric lipomatosis(Madelung disease), Dercum's Disease, familiallipodystrophy,hibernomas,epidural steroid injections with epidural lipomatosis,[6]and familial angiolipomatosis.
Etymology
[edit]"fatty tumor" (plural lipomata), 1830, medical Latin, from Greek lipos "fat" (n.), from PIE root *leip- "to stick, adhere," also used to form words for "fat," + -oma.
word-forming element expressing state or condition, in medical terminology denoting "a state of disease," from Latin -osis and directly from Greek -osis, formed from the aorist of verbs ending in -o. It corresponds to Latin -atio.
See also
[edit]- Pelvic lipomatosis— Arare diseasemost often seen in olderobeseblack men withhypertension.
- Virchow's metamorphosis— lipomatosis in theheartandsalivary glands.
- Dercums— A rare condition characterized by generalized obesity and painful fatty tumors in theadipose tissue.
References
[edit]- ^abToy, Brian R. (May 1, 2003)."Familial multiple lipomatosis".Dermatology Online Journal.9(4) – via escholarship.org.
- ^Schoenmakers, EF; Wanschura, S; Mols, R; Bullerdiek, J; Van Den Berghe, H; Van De Ven, WJ (1995). "Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours".Nature Genetics.10(4): 436–44.doi:10.1038/ng0895-436.PMID7670494.
- ^Weiss, SW (1996). "Lipomatous tumors".Monographs in Pathology.38:207–39.PMID8744279.
- ^Gologorsky, Y; Gologorsky, D; Yarygina, AS; Surti, U; Zirwas, MJ (2007). "Familial multiple lipomatosis: Report of a new family".Cutis; Cutaneous Medicine for the Practitioner.79(3): 227–32.PMID17674589.
- ^Online Mendelian Inheritance in Man(OMIM):Lipomatosis, Familial Multiple Lipomatosis, FML - 151900
- ^Jaimes R, Rocco AG (2014)."Multiple epidural steroid injections and body mass index linked with occurrence of epidural lipomatosis: a case series".BMC Anesthesiol.14:70.doi:10.1186/1471-2253-14-70.PMC4145583.PMID25183952.