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Lubert Stryer

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Lubert Stryer
Born(1938-03-02)March 2, 1938
Tianjin,China
DiedApril 8, 2024(2024-04-08)(aged 86)
Stanford, California,U.S.
CitizenshipUnited States
EducationUniversity of Chicago(B.S. 1957)
Harvard Medical School(M.D.)
Known forTextbookBiochemistry(ten editions)
AwardsNational Academy of Sciences,European Inventor of the Year(2006),Eli Lilly Award in Biological Chemistry
Scientific career
FieldsBiochemistry, fluorescence spectroscopy
InstitutionsDepartment of physics atHarvard;MRC Laboratory of Molecular Biologyat Cambridge, UK; department of biochemistry atStanford University;Yale University
Notable studentsRichard P. Haugland,Jeremy M. Berg

Lubert Stryer(March 2, 1938 – April 8, 2024) was an American academic who was the Emeritus Mrs. George A. Winzer Professor ofCell Biology,atStanford University School of Medicine.[1][2]His research over more than four decades had been centered on the interplay of light and life. In 2007 he received theNational Medal of SciencefromPresident Bushat a ceremony at the White House for elucidating the biochemical basis of signal amplification in vision, pioneering the development of high densitymicroarraysforgenetic analysis,and authoring the standard undergraduate biochemistry textbook,Biochemistry.[3]It is now in its tenth edition and also edited byJeremy Berg,Justin Hines, John L. Tymoczko and Gregory J. Gatto, Jr.[4]

Stryer received his B.S. degree from theUniversity of Chicagoin 1957 and his M.D. degree fromHarvard Medical School.He was aHelen Hay WhitneyResearch Fellow[5]in the department of physics at Harvard and then at theMRC Laboratory of Molecular Biology[6]inCambridge,England, before joining the faculty of the department of biochemistry atStanfordin 1963. In 1969 he moved toYaleto become Professor of Molecular Biophysics and Biochemistry, and in 1976, he returned to Stanford to head a new Department of Structural Biology.[2][7]

Stryder died in Stanford, California April 8, 2024, at the age of 86.[8]

Research profile[edit]

Stryer and coworkers pioneered the use of fluorescence spectroscopy, particularlyFörster resonance energy transfer(FRET), to monitor the structure and dynamics of biological macromolecules.[9][10]In 1967, Stryer andHauglandshowed that the efficiency of energy transfer depends on the inverse sixth power of the distance between the donor and acceptor,[11][12]as predicted by Förster's theory. They proposed that energy transfer can serve as a spectroscopic ruler to reveal proximity relationships in biological macromolecules.

A second contribution was Stryer's discovery of the primary stage of amplification in visual excitation.[13][14]Stryer, together with Fung and Hurley, showed that a single photoexcited rhodopsin molecule activates many molecules of transducin, which in turn activate many molecules of a cyclic GMP phosphodiesterase. Stryer's laboratory has also contributed to our understanding of the role of calcium in visual recovery and adaptation.[15][16][17]

Stryer participated in developing light-directed, spatially addressable parallel chemical synthesis for the synthesis of peptides and polynucleotides.[18][19][20]Light-directed combinatorial synthesis has been used byStephen Fodorand coworkers atAffymetrixto make DNA arrays containing millions of different sequences for genetic analyses.

From 1975, Stryer authored ten editions of the textbookBiochemistry.[21]

Stryer also chaired a National Research Council committee that produced a report entitledBio2010: Transforming Undergraduate Education for Future Research Biologists.[22][23]

Honors[edit]

Notable students[edit]

References[edit]

  1. ^"Lubert Stryer".
  2. ^abc"Our Apologies | American Philosophical Society".Archived fromthe originalon July 20, 2012.RetrievedMarch 10,2012.
  3. ^"President to Award 2005-2006 National Medals of Science and National Medals of Technology Honoring Nation's Leading Researchers, Inventors and Innovators - NSF - National Science Foundation".
  4. ^Stryer; et al. (2023).Biochemistry(10 ed.). Palgrave Macmillan.ISBN978-1319498504.
  5. ^"Archived copy".Archived fromthe originalon November 14, 2012.RetrievedApril 1,2012.{{cite web}}:CS1 maint: archived copy as title (link)
  6. ^"Alumni - MRC Laboratory of Molecular Biology".MRC Laboratory of Molecular Biology.
  7. ^McCarthy, Pumtiwitt."Everything is illuminated: 'Reflections' on light and life by Lubert Stryer".American Society for Biochemistry and Molecular Biology.RetrievedJune 19,2016.
  8. ^Bai, Nina (May 1, 2024)."Lubert Stryer, luminary scientist of light and life, author of classic textbook, dies at 86".Stanford Medicine.RetrievedMay 4,2024.
  9. ^Stryer, L (1968). "Fluorescence spectroscopy of proteins".Science.1632(3853): 526–533.Bibcode:1968Sci...162..526S.doi:10.1126/science.162.3853.526.PMID5706935.
  10. ^"Invitrogen - Molecular Probes - Press Release".Archived fromthe originalon June 14, 2011.RetrievedOctober 18,2010.
  11. ^Stryer, L.; Haugland, R.P. (1967)."Energy transfer: a spectroscopic ruler".Proc. Natl. Acad. Sci. USA.58(2): 719–725.Bibcode:1967PNAS...58..719S.doi:10.1073/pnas.58.2.719.PMC335693.PMID5233469.
  12. ^Lakowicz, J.R., 2006.Principles of Fluorescence Spectroscopy(Springer, 3rd ed., p. 449)
  13. ^Fung, B.; Hurley, J.B.; Stryer, L. (1981)."Flow of information in the light-triggered cyclic nucleotide cascade of vision".Proc. Natl. Acad. Sci. USA.78(1): 152–156.Bibcode:1981PNAS...78..152F.doi:10.1073/pnas.78.1.152.PMC319009.PMID6264430.
  14. ^"Chemical & Engineering News - Serving the chemical, life sciences and laboratory worlds".
  15. ^Koch, K.-W.; Stryer, L. (1988). "Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ion".Nature.334(6177): 64–66.Bibcode:1988Natur.334...64K.doi:10.1038/334064a0.PMID2455233.S2CID4253998.
  16. ^<Ames, J.B., Ishima, R., Tanaka, T., Gordon, J.I., Stryer, L., Ikura, M., 1997. Molecular mechanics of calcium-myristoyl switches.Nature389:198-202
  17. ^Burgoyne, R.D.; Weiss, J.L. (2001)."The neuronal calcium sensor family of Ca2+-binding proteins".Biochem. J.353(Pt 1): 1–12.doi:10.1042/bj3530001.PMC1221537.PMID11115393.
  18. ^Fodor, S.P.A.; Read, J.L.; Pirrung, M.C.; Stryer, L.; Lu, A.T.; Solas, D. (1991). "Light-directed, spatially addressable parallel chemical synthesis".Science.251(4995): 767–773.Bibcode:1991Sci...251..767F.doi:10.1126/science.1990438.PMID1990438.
  19. ^Fodor, S.P.A., Pirrung, M.C., Read, J.L., and Stryer, L., Array of oligonucleotides on a solid substrate. U.S. Patent No. 5,445,934. Issued August 29, 1995
  20. ^"2007 Newcomb Cleveland Prize Recipients".AAAS - The World's Largest General Scientific Society.
  21. ^Latchman,D.S. (1995)Trends Biochem. Sci.20:488.
  22. ^Council, National Research; Studies, Division on Earth Life; Sciences, Board on Life; Century, Committee on Undergraduate Biology Education to Prepare Research Scientists for the 21st (2003).BIO2010: Transforming Undergraduate Education for Future Research Biologists - The National Academies Press.doi:10.17226/10497.ISBN978-0-309-08535-9.PMID20669482.{{cite book}}:CS1 maint: numeric names: authors list (link)
  23. ^Kennedy, D (2003)."Points of View: Is Bio2010 the Right Blueprint for the Biology of the Future?".Cell Biol Educ.2(4): 224–7.doi:10.1187/cbe.03-10-0039.PMC256982.PMID14673487.
  24. ^"Recipients - ACS Division of Biological Chemistry Website".
  25. ^"American Academy of Arts & Sciences".
  26. ^"National Academy of Sciences".
  27. ^"AAAS Awards and Honors".archives.aaas.org.RetrievedOctober 23,2019.
  28. ^1992http://convocation.uchicago.edu/page/1990Archived2019-02-16 at theWayback Machine
  29. ^"Roche Life Science | Welcome".lifescience.roche.RetrievedOctober 24,2019.
  30. ^"Lubert Stryer".
  31. ^European Patent Office."EPO - Stephen P.A. Fodor, Michael C. Pirrung, J. Leighton Read and Lubert Stryer (Affymax Research Institute, Palo Alto, USA)".
  32. ^"Faculty & Research".
  33. ^"Meyer Lab".Archived fromthe originalon April 11, 2009.RetrievedApril 1,2012.
  34. ^"Tobias Meyer - Mrs. George A. Winzer Professor in Cell Biology and Professor of Chemical & Systems Biology | Welcome to Bio-X".
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