Lymecycline
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| Clinical data | |
|---|---|
| Trade names | Tetralysal |
| AHFS/Drugs | International Drug Names |
| Routes of administration | By mouth |
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| Pharmacokineticdata | |
| Bioavailability | 100% (oral) |
| Eliminationhalf-life | 10 hours |
| Excretion | Kidney |
| Identifiers | |
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| CAS Number | |
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| DrugBank | |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.012.357 |
| Chemical and physical data | |
| Formula | C29H38N4O10 |
| Molar mass | 602.641g·mol−1 |
| 3D model (JSmol) | |
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Lymecyclineis atetracyclinebroad-spectrum antibiotic.It is approximately 5,000 times moresolublethantetracyclinebase and is unique amongst tetracyclines in that it isabsorbedby anactive transportprocess across the intestinal wall, making use of the same fast and efficient mechanism by whichcarbohydratesare absorbed.[1]
The greater absorption of lymecycline allows for lower dosages to be used; the standard dose of 408 mg is equivalent to 300 mg tetracycline base and, in its action, to 500 mg tetracycline hydrochloride. Lymecycline, unlike tetracycline hydrochloride, is soluble at allphysiologicalpHvalues.[citation needed]
History
[edit]Lymecycline was introduced byFarmitaliain 1963.[citation needed]
Indications
[edit]Lymecycline, like other tetracyclines, is used to treat a range of infections.
Acne
[edit]Its better absorption profile makes it preferable to tetracycline for moderately severeacneand typically prescribed for 8 weeks at a time, but alternatives should be sought if no improvement occurs by 3 months.[2]
Side effects
[edit]Lymecycline's side effects can includerash,headache,diarrhoea,nausea,vomiting,dermatitis,inflammation of the liver,hypersensitive reactions,andvisual disturbances.When taken for a long period of time, it can causereflux oesophagitis.[3]Recently, the family of tetracycline antibiotics has been associated with thyroid dysfunction in youth.[4]
See also
[edit]References
[edit]- ^New ZealandDatasheetArchived2006-03-03 at theWayback MachineAugust 2003
- ^British National Formulary45March 2003
- ^Wang P."Side effects of Tetralysal".Retrieved23 March2011.
- ^Pollock AJ, Seibert T, Allen DB (June 2016)."Severe and Persistent Thyroid Dysfunction Associated with Tetracycline-Antibiotic Treatment in Youth".The Journal of Pediatrics.173:232–4.doi:10.1016/j.jpeds.2016.03.034.PMC4884496.PMID27059913.