Methitural
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| Formula | C12H20N2O2S2 |
| Molar mass | 288.42g·mol−1 |
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Methitural(INN;Neraval,Thiogenal), ormethitural sodium,also known asmethioturiate,is abarbituratederivativewhich was marketed in the 1950s inEurope(inGermanyandItaly) as an ultra-short-actingintravenousanesthetic.[1][2][3]
Synthesis[edit]
A somewhat more complex side chain is incorporated by alkylation of the carbanion of the substitutedcyanoacetate(1) with 2-chloroethylmethyl sulfide (2). Condensation of the resulting cyanoester (3) with thiourea followed by hydrolysis of the resulting imine affords methitural.
See also[edit]
References[edit]
- ^Macdonald F (1997).Dictionary of Pharmacological Agents.CRC Press. p. 1300.ISBN978-0-412-46630-4.Retrieved19 May2012.
- ^Houde J, Hudon F, Jacques A (January 1957)."Neraval (methitural sodium) (sch. 3132)".Canadian Anaesthetists' Society Journal.4(1): 43–6.doi:10.1007/bf03009193.PMID13396640.
- ^Irwin S, Stagg RD, Dunbar E, Govier WM (March 1956)."Methitural, a new intravenous anesthetic: comparison with thiopental in the cat, dog and monkey".The Journal of Pharmacology and Experimental Therapeutics.116(3): 317–25.PMID13307393.
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