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NRIP1

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NRIP1
Available structures
PDBOrtholog search:PDBeRCSB
Identifiers
AliasesNRIP1,RIP140, nuclear receptor interacting protein 1, CAKUT3
External IDsOMIM:602490;MGI:1315213;HomoloGene:2606;GeneCards:NRIP1;OMA:NRIP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

8204

268903

Ensembl

ENSG00000180530

ENSMUSG00000048490

UniProt

P48552

Q8CBD1

RefSeq (mRNA)

NM_003489

NM_173440
NM_001358238

RefSeq (protein)

NP_003480

NP_775616
NP_001345167

Location (UCSC)Chr 21: 14.96 – 15.07 MbChr 16: 76.08 – 76.17 Mb
PubMedsearch[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Nuclear receptor-interacting protein 1 repression 1
Identifiers
SymbolNRIP1_repr_1
PfamPF15687
Available protein structures:
Pfam structures/ECOD
PDBRCSB PDB;PDBe;PDBj
PDBsumstructure summary
Nuclear receptor-interacting protein 1 repression 2
Identifiers
SymbolNRIP1_repr_2
PfamPF15688
Available protein structures:
Pfam structures/ECOD
PDBRCSB PDB;PDBe;PDBj
PDBsumstructure summary
Nuclear receptor-interacting protein 1 repression 3
Identifiers
SymbolNRIP1_repr_3
PfamPF15689
Available protein structures:
Pfam structures/ECOD
PDBRCSB PDB;PDBe;PDBj
PDBsumstructure summary
Nuclear receptor-interacting protein 1 repression 4
Identifiers
SymbolNRIP1_repr_4
PfamPF15690
Available protein structures:
Pfam structures/ECOD
PDBRCSB PDB;PDBe;PDBj
PDBsumstructure summary

Nuclear receptor-interacting protein 1(NRIP1) also known asreceptor-interacting protein 140(RIP140) is aproteinthat in humans is encoded by theNRIP1gene.[5][6]

Function

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Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 ofnuclear receptors.Also known as RIP140, this protein is a key regulator which modulates transcriptional activity of a variety of transcription factors, including theestrogen receptor.[7]

RIP140 has an important role in regulating lipid and glucose metabolism,[8]and regulates gene expression in metabolic tissues including heart,[9]skeletal muscle,[10]and liver.[11]A major role for RIP140 in adipose tissue is to block the expression of genes involved in energy dissipation andmitochondrialuncoupling, includinguncoupling protein 1andcarnitine palmitoyltransferase 1b.[12]

Estrogen-related receptor Alpha(ERRa) can activate RIP140 during adipogenesis, by means of directly binding to an estrogen receptor element/ERR element and indirectly throughSp1binding to the proximal promoter.[13]

RIP140 suppresses the expression of mitochondrial proteinssuccinate dehydrogenasecomplex b andCoxVband acts as a negative regulator of glucose uptake in mice.[14]

Knockout studies

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Knockout micethat completely lack the RIP140 molecule are lean and stay lean, even on a rich diet.[15]

Knockout mice (females) are also infertile because they fail toovulate.[16]Failure of ovulation in these mice is caused by lack ofcumulusexpansion and altered expression of various genes, includingamphiregulin,inovarian follicles.[17][18]

Clinical significance

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RIP140 is part of the chain by which tumors can causecachexia.[19][20]

Levels of RIP140 expression in various tissues varies during aging in mice, suggesting changes in metabolic function.[21]RIP140 is implicated in certain human disease processes. In morbid obesity, RIP140 levels are down-regulated in visceral adipose tissue.[22]In breast cancer, RIP140 is involved in regulation of E2F1, an oncogene which discriminates between luminal and basal types of tumours. RIP140 has an influence upon cancer phenotype and prognosis.[23]In addition, RIP140 has a role in inflammation, since it acts as a coactivator forNFkappaB/RelA-dependentcytokinegene expression. Lack of RIP140 leads to an inhibition of proinflammatory pathways inmacrophages.[24]

Interactions

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NRIP1 has been shown tointeractwith:

See also

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References

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  1. ^abcGRCh38: Ensembl release 89: ENSG00000180530–Ensembl,May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000048490–Ensembl,May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^abCavailles V, Dauvois S, L'Horset F, Lopez G, Hoare S, Kushner PJ, Parker MG (Sep 1995)."Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor".EMBO J.14(15): 3741–51.doi:10.1002/j.1460-2075.1995.tb00044.x.PMC394449.PMID7641693.
  6. ^Katsanis N, Ives JH, Groet J, Nizetic D, Fisher EM (Apr 1998). "Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome".Hum Genet.102(2): 221–3.doi:10.1007/s004390050682.PMID9521594.S2CID1042332.
  7. ^"Entrez Gene: NRIP1 nuclear receptor interacting protein 1".
  8. ^Rosell M, Jones MC, Parker MG (2010)."Role of nuclear receptor corepressor RIP140 in metabolic syndrome".Biochim Biophys Acta.1812(8): 919–28.doi:10.1016/j.bbadis.2010.12.016.PMC3117993.PMID21193034.
  9. ^Fritah A, Steel JH, Nichol D, Parker N, Williams S, Price A, Strauss L, Ryder TA, Mobberley MA, Poutanen M, Parker M, White R (2010)."Elevated expression of the metabolic regulator receptor-interacting protein 140 results in cardiac hypertrophy and impaired cardiac function".Cardiovasc Res.86(3): 443–451.doi:10.1093/cvr/cvp418.PMC2868176.PMID20083575.
  10. ^Seth A, Steel JH, Nichol D, Pocock V, Kumaran MK, Fritah A, Mobberley M, Ryder TA, Rowlerson A, Scott J, Poutanen M, White R, Parker M (Sep 2007)."The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle".Cell Metab.6(3): 236–245.doi:10.1016/j.cmet.2007.08.004.PMC2680991.PMID17767910.
  11. ^Herzog B, Hallberg M, Seth A, Woods A, White R, Parker MG (Nov 2007)."The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor".Mol Endocrinol.21(11): 2687–97.doi:10.1210/me.2007-0213.PMC2140279.PMID17684114.
  12. ^Debevec D, Christian M, Morganstein D, Seth A, Herzog B, Parker M, White R (July 2007)."Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor Alpha".Mol. Endocrinol.21(7): 1581–92.doi:10.1210/me.2007-0103.PMC2072047.PMID17456798.
  13. ^Nichol D, Christian M, Steel JH, White R, Parker MG (Oct 2006)."RIP140 expression is stimulated by estrogen-related receptor Alpha during adipogenesis".J Biol Chem.281(43): 32140–32147.doi:10.1074/jbc.M604803200.PMID16923809.
  14. ^Powelka AM, Seth A, Virbasius JV, Kiskinis E, Nicoloro SM, Guilherme A, Tang X, Straubhaar J, Cherniack AD, Parker MG, Czech MP (2006)."Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes".J Clin Invest.116(1): 125–136.doi:10.1172/JCI26040.PMC1319222.PMID16374519.
  15. ^Leonardsson G, Steel JH, Christian M, Pocock V, Milligan S, Bell J, So PW, Medina-Gomez G, Vidal-Puig A, White R, Parker MG (May 2004)."Nuclear receptor corepressor RIP140 regulates fat accumulation".Proc Natl Acad Sci U S A.101(22): 8437–42.Bibcode:2004PNAS..101.8437L.doi:10.1073/pnas.0401013101.PMC420412.PMID15155905.
  16. ^White R, Leonardsson G, Rosewell I, Ann Jacobs M, Milligan S, Parker M (Dec 2000). "The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility".Nat. Med.6(12): 1368–74.doi:10.1038/82183.PMID11100122.S2CID20285964.
  17. ^Tullet JM, Pocock V, Steel JH, White R, Milligan S, Parker MG (2005)."Multiple Signaling Defects in the Absence of RIP140 Impair Both Cumulus Expansion and Follicle Rupture".Endocrinology.146(9): 4127–4137.doi:10.1210/EN.2005-0348.PMID15919748.
  18. ^Nautiyal J, Steel JH, Rosell MM, Nikolopoulou E, Lee K, Demayo FJ, White R, Richards JS, Parker MG (2010)."The nuclear receptor cofactor receptor-interacting protein 140 is a positive regulator of amphiregulin expression and cumulus cell-oocyte complex expansion in the mouse ovary".Endocrinology.151(6): 2923–2932.doi:10.1210/en.2010-0081.PMC2875814.PMID20308529.
  19. ^"A common denominator of inflammations and fatty liver".News.Science Centric. 2008-05-31.Retrieved2008-08-31.[dead link]
  20. ^Diaz MB, Krones-Herzig A, Metzger D, Ziegler A, Vegiopoulos A, Klingenspor M, Müller-Decker K, Herzig S (April 2008)."Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice".Hepatology.48(3): 782–791.doi:10.1002/hep.22383.PMID18712775.S2CID26235707.
  21. ^Ghosh S, Thakur MK (2008)."Tissue-specific expression of receptor-interacting protein in aging mouse".Age (Dordr).30(4): 237–243.doi:10.1007/s11357-008-9062-3.PMC2585652.PMID19424847.
  22. ^Catalán V, Gómez-Ambrosi J, Lizanzu A, Rodríguez A, Silva C, Rotellar F, Gil MJ, Cienfuegos JA, Salvador J, Frühbeck G (2009). "RIP140 gene and protein expression levels are downregulated in visceral adipose tissue in human morbid obesity".Obes Surg.19(6): 771–776.doi:10.1007/s11695-009-9834-6.PMID19367438.S2CID787869.
  23. ^Docquier A, Harmand PO, Fritsch S, Chanrion M, Darbon JM, Cavaillès V (2010)."The transcriptional coregulator RIP140 represses E2F1 activity and discriminates breast cancer subtypes".Clin Cancer Res.16(11): 2959–2970.doi:10.1158/1078-0432.CCR-09-3153.PMC3112174.PMID20410059.
  24. ^Zschiedrich I, Hardeland U, Krones-Herzig A, Berriel DM, Vegiopoulos A, Müggenburg J, Sombroek D, Hofmann TG, Zawatzky R, Yu X, Gretz N, Christian M, White R, Parker MG, Herzig S (2008). "Coactivator function of RIP140 for NFkappaB/RelA-dependent cytokine gene expression".Blood.112(2): 264–276.doi:10.1182/blood-2007-11-121699.PMID18469200.
  25. ^Kumar MB, Tarpey RW, Perdew GH (Aug 1999)."Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs".J. Biol. Chem.274(32): 22155–64.doi:10.1074/jbc.274.32.22155.PMID10428779.
  26. ^abcCastet A; Boulahtouf Abdelhay; Versini Gwennaëlle; Bonnet Sandrine; Augereau Patrick; Vignon Françoise; Khochbin Saadi; Jalaguier Stéphan; Cavaillès Vincent (2004)."Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition".Nucleic Acids Res.32(6): 1957–66.doi:10.1093/nar/gkh524.PMC390375.PMID15060175.
  27. ^Perissi V; Scafoglio Claudio; Zhang Jie; Ohgi Kenneth A; Rose David W; Glass Christopher K; Rosenfeld Michael G (Mar 2008)."TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints".Mol. Cell.29(6): 755–66.doi:10.1016/j.molcel.2008.01.020.PMC2364611.PMID18374649.
  28. ^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437(7062): 1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID16189514.S2CID4427026.
  29. ^abSugawara T, Abe S, Sakuragi N, Fujimoto Y, Nomura E, Fujieda K, Saito M, Fujimoto S (August 2001)."RIP 140 modulates transcription of the steroidogenic acute regulatory protein gene through interactions with both SF-1 and DAX-1".Endocrinology.142(8): 3570–7.doi:10.1210/endo.142.8.8309.PMID11459805.
  30. ^Hu X; Chen Yixin; Farooqui Mariya; Thomas Mary C; Chiang Cheng-Ming; Wei Li-Na (Jan 2004)."Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation".J. Biol. Chem.279(1): 319–25.doi:10.1074/jbc.M307621200.PMID14581481.
  31. ^abFarooqui M; Franco Peter J; Thompson Jim; Kagechika Hiroyuki; Chandraratna Roshantha A S; Banaszak Len; Wei Li-Na (Feb 2003). "Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity".Biochemistry.42(4): 971–9.doi:10.1021/bi020497k.PMID12549917.
  32. ^abcL'Horset F, Dauvois S, Heery DM, Cavaillès V, Parker MG (Nov 1996)."RIP-140 interacts with multiple nuclear receptors by means of two distinct sites".Mol. Cell. Biol.16(11): 6029–36.doi:10.1128/MCB.16.11.6029.PMC231605.PMID8887632.
  33. ^Thénot S, Henriquet C, Rochefort H, Cavaillès V (May 1997)."Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1".J. Biol. Chem.272(18): 12062–8.doi:10.1074/jbc.272.18.12062.PMID9115274.
  34. ^abZilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA (Apr 2001)."Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140".Mol. Endocrinol.15(4): 501–11.doi:10.1210/mend.15.4.0624.PMID11266503.
  35. ^Tazawa H; Osman Waffa; Shoji Yutaka; Treuter Eckardt; Gustafsson Jan-Ake; Zilliacus Johanna (Jun 2003)."Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140".Mol. Cell. Biol.23(12): 4187–98.doi:10.1128/MCB.23.12.4187-4198.2003.PMC156128.PMID12773562.
  36. ^Subramaniam N, Treuter E, Okret S (Jun 1999)."Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids".J. Biol. Chem.274(25): 18121–7.doi:10.1074/jbc.274.25.18121.PMID10364267.
  37. ^Mellgren G; Børud Bente; Hoang Tuyen; Yri Olav Erich; Fladeby Cathrine; Lien Ernst Asbjørn; Lund Johan (May 2003). "Characterization of receptor-interacting protein RIP140 in the regulation of SF-1 responsive target genes".Mol. Cell. Endocrinol.203(1–2): 91–103.doi:10.1016/S0303-7207(03)00097-2.PMID12782406.S2CID733221.

Further reading

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This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.

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