Oxiconazole
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Clinical data | |
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Trade names | Oxistat, Oxizole |
AHFS/Drugs | Monograph |
MedlinePlus | a689004 |
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Chemical and physical data | |
Formula | C18H13Cl4N3O |
Molar mass | 429.12g·mol−1 |
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Oxiconazole(trade namesOxistatin the US,Oxizolein Canada) is anantifungal medicationtypically administered in a cream or lotion to treatskininfections,such asathlete's foot,jock itchandringworm.It can also be prescribed to treat theskin rashknown astinea versicolor,caused by systemic yeast overgrowth (Candidaspp.).
It was patented in 1975 and approved for medical use in 1983.[1]
Synthesis
[edit]Treatment of theketone(1) withhydroxylaminegives theoxime(2), which isalkylatedwith 2,4-dichlorobenzyl chloride (3) in the presence of the strong basesodium hydrideto give oxiconazole.[2][3]
See also
[edit]References
[edit]- ^Fischer J, Ganellin CR (2006).Analogue-based Drug Discovery.John Wiley & Sons. p. 503.ISBN9783527607495.
- ^Georg Mixich, Kurt Thiele,U.S. patent 4,550,175(1985 to Siegfried Aktiengesellschaft).
- ^ "Oxiconazole".Thieme.Retrieved2024-06-30.
External links
[edit]- MedlinePlus- Oxiconazole