P2RY1
Appearance
P2Y purinoceptor 1is aproteinthat in humans is encoded by theP2RY1gene.[5]
Function
[edit]The product of this gene, P2Y1belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.[6]
See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000169860–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000027765–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Ayyanathan K, Webbs TE, Sandhu AK, Athwal RS, Barnard EA, Kunapuli SP (January 1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor".Biochemical and Biophysical Research Communications.218(3): 783–8.doi:10.1006/bbrc.1996.0139.PMID8579591.
- ^"Entrez Gene: P2RY1 purinergic receptor P2Y, G-protein coupled, 1".
Further reading
[edit]- Janssens R, Communi D, Pirotton S, Samson M, Parmentier M, Boeynaems JM (April 1996)."Cloning and tissue distribution of the human P2Y1 receptor".Biochemical and Biophysical Research Communications.221(3): 588–93.doi:10.1006/bbrc.1996.0640.PMID8630005.
- Léon C, Vial C, Cazenave JP, Gachet C (June 1996). "Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor".Gene.171(2): 295–7.doi:10.1016/0378-1119(96)00027-3.PMID8666290.
- Léon C, Hechler B, Vial C, Leray C, Cazenave JP, Gachet C (February 1997). "The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells".FEBS Letters.403(1): 26–30.doi:10.1016/S0014-5793(97)00022-7.PMID9038354.S2CID10518131.
- Ayyanathan K, Naylor SL, Kunapuli SP (September 1996). "Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1)".Somatic Cell and Molecular Genetics.22(5): 419–24.doi:10.1007/BF02369897.PMID9039850.S2CID28971344.
- Maier R, Glatz A, Mosbacher J, Bilbe G (August 1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues".Biochemical and Biophysical Research Communications.237(2): 297–302.doi:10.1006/bbrc.1997.7135.PMID9268704.
- Jin J, Daniel JL, Kunapuli SP (January 1998)."Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets".The Journal of Biological Chemistry.273(4): 2030–4.doi:10.1074/jbc.273.4.2030.PMID9442040.
- Hall RA, Ostedgaard LS, Premont RT, Blitzer JT, Rahman N, Welsh MJ, Lefkowitz RJ (July 1998)."A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins".Proceedings of the National Academy of Sciences of the United States of America.95(15): 8496–501.Bibcode:1998PNAS...95.8496H.doi:10.1073/pnas.95.15.8496.PMC21104.PMID9671706.
- Sabala P, Czajkowski R, Przybyłek K, Kalita K, Kaczmarek L, Barańska J (January 2001)."Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells".British Journal of Pharmacology.132(2): 393–402.doi:10.1038/sj.bjp.0703843.PMC1572584.PMID11159687.
- Yoshioka K, Saitoh O, Nakata H (June 2001)."Heteromeric association creates a P2Y-like adenosine receptor".Proceedings of the National Academy of Sciences of the United States of America.98(13): 7617–22.Bibcode:2001PNAS...98.7617Y.doi:10.1073/pnas.121587098.PMC34717.PMID11390975.
- James G, Butt AM (October 2001). "Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve".Neuroscience Letters.312(1): 33–6.doi:10.1016/S0304-3940(01)02189-9.PMID11578839.S2CID30936205.
- Moore DJ, Chambers JK, Wahlin JP, Tan KB, Moore GB, Jenkins O, Emson PC, Murdock PR (October 2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1521(1–3): 107–19.doi:10.1016/S0167-4781(01)00291-3.PMID11690642.
- Czajkowski R, Lei L, Sabała P, Barańska J (February 2002). "ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12)".FEBS Letters.513(2–3): 179–83.doi:10.1016/S0014-5793(02)02255-X.PMID11904146.S2CID43212335.
- Aktas B, Hönig-Liedl P, Walter U, Geiger J (August 2002). "Inhibition of platelet P2Y12 and Alpha 2A receptor signaling by cGMP-dependent protein kinase".Biochemical Pharmacology.64(3): 433–9.doi:10.1016/S0006-2952(02)01113-9.PMID12147294.
- Nurden P, Poujol C, Winckler J, Combrié R, Pousseau N, Conley PB, Levy-Toledano S, Habib A, Nurden AT (February 2003)."Immunolocalization of P2Y1 and TP Alpha receptors in platelets showed a major pool associated with the membranes of Alpha -granules and the open canalicular system".Blood.101(4): 1400–8.doi:10.1182/blood-2002-02-0642.PMID12393588.S2CID30407515.
- Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (March 2003)."Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors".The Journal of Investigative Dermatology.120(3): 440–7.doi:10.1046/j.1523-1747.2003.12050.x.PMID12603858.
- Jagroop IA, Burnstock G, Mikhailidis DP (February 2003). "Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets".Platelets.14(1): 15–20.doi:10.1080/0953710021000062914.PMID12623443.S2CID13637415.
- Greig AV, Linge C, Terenghi G, McGrouther DA, Burnstock G (June 2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes".The Journal of Investigative Dermatology.120(6): 1007–15.doi:10.1046/j.1523-1747.2003.12261.x.PMID12787128.
- Wang L, Ostberg O, Wihlborg AK, Brogren H, Jern S, Erlinge D (February 2003). "Quantification of ADP and ATP receptor expression in human platelets".Journal of Thrombosis and Haemostasis.1(2): 330–6.doi:10.1046/j.1538-7836.2003.00070.x.PMID12871508.S2CID19101147.
External links
[edit]- "P2Y Receptors: P2Y1".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology. Archived fromthe originalon 2016-03-03.Retrieved2008-12-09.
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.