3',5'-cyclic-AMP phosphodiesterase
(Redirected fromPDE7)
| 3′,5′-cyclic-AMP phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.4.53 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDBstructures | RCSB PDBPDBePDBsum | ||||||||
| |||||||||
3′,5′-cyclic-AMP phosphodiesterase(EC 3.1.4.53,cAMP-specific phosphodiesterase, cAMP-specific PDE,PDE1,PDE2A,PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is anenzymewithsystematic name3′,5′-cyclic-AMP 5′-nucleotidohydrolase.[1][2][3][4][5][6]Itcatalysesthe following reaction
- adenosine 3′,5′-cyclic phosphate + H2OAMP
This enzyme requires Mg2+or Mn2+for activity.
References
[edit]- ^Alonso GD, Schoijet AC, Torres HN, Flawiá MM (January 2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase fromTrypanosoma cruzi".Molecular and Biochemical Parasitology.145(1): 40–9.doi:10.1016/j.molbiopara.2005.09.005.hdl:11336/79656.PMID16225937.
- ^Bader S, Kortholt A, Snippe H, Van Haastert PJ (July 2006)."DdPDE4, a novel cAMP-specific phosphodiesterase at the surface ofDictyosteliumcells ".The Journal of Biological Chemistry.281(29): 20018–26.doi:10.1074/jbc.M600040200.PMID16644729.
- ^Rascón A, Soderling SH, Schaefer JB, Beavo JA (April 2002)."Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) fromTrypanosoma brucei".Proceedings of the National Academy of Sciences of the United States of America.99(7): 4714–9.Bibcode:2002PNAS...99.4714R.doi:10.1073/pnas.002031599.PMC123713.PMID11930017.
- ^Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (March 2006)."Cyclic nucleotide specific phosphodiesterases ofLeishmania major".BMC Microbiology.6:25.doi:10.1186/1471-2180-6-25.PMC1431542.PMID16522215.
- ^Lugnier C, Keravis T, Le Bec A, Pauvert O, Proteau S, Rousseau E (November 1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei".Biochimica et Biophysica Acta (BBA) - General Subjects.1472(3): 431–446.doi:10.1016/S0304-4165(99)00145-2.PMID10564757.
- ^Imamura R, Yamanaka K, Ogura T, Hiraga S, Fujita N, Ishihama A, Niki H (October 1996)."Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase inEscherichia coli".The Journal of Biological Chemistry.271(41): 25423–9.doi:10.1074/jbc.271.41.25423.PMID8810311.
External links
[edit]- 3',5'-cyclic-AMP+phosphodiesteraseat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
