PMP2

PMP2
Available structures
PDB	Ortholog search:PDBeRCSB
List of PDB id codes
	2WUT,3NR3,4A1H,4A1Y,4A8Z,4BVM,4D6A,4D6B
Identifiers
Aliases	PMP2,FABP8, M-FABP, MP2, P2, peripheral myelin protein 2, Myelin P2 protein, CMT1G
External IDs	OMIM:170715;MGI:102667;HomoloGene:20589;GeneCards:PMP2;OMA:PMP2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	81,447,439bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	10,248,989bp
RNA expressionpattern
	Top expressed in
	olfactory bulb; ; superior vestibular nucleus; ; trigeminal ganglion; ; inferior ganglion of vagus nerve; ; ventral tegmental area; ; subthalamic nucleus; ; external globus pallidus; ; pars reticulata; ; Pars compacta; ; internal globus pallidus;
	Top expressed in
	blastocyst; ; morula; ; spermatocyte; ; neural layer of retina; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; zone of skin; ; testicle; ; esophagus; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fatty acid binding; cholesterol binding; protein binding; lipid binding; transporter activity;
Cellular component	cytoplasm; myelin sheath; extracellular exosome;
Biological process	membrane organization; transport;
	Sources:Amigo/QuickGO
Orthologs
	5375
	18857
	ENSG00000147588
	ENSMUSG00000052468
	P02689
	P24526
	NM_002677; NM_001348381
	NM_001030305
	NP_002668; NP_001335310
	NP_001025476
	Wikidata
View/Edit Human	View/Edit Mouse

Myelin P2 proteinis aproteinthat in humans is encoded by thePMP2gene.^[5]^[6]^[7] Myelin protein P2 is a constituent ofperipheral nervous system(PNS)myelin,also present in small amounts incentral nervous system(CNS) myelin. As a structural protein, P2 is thought to stabilize the myelin membranes, and may play a role in lipid transport inSchwann cells.Structurally, P2 belongs to the family of cytoplasmic fatty acid-binding proteins(FABPs).

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000147588–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000052468–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hayasaka K, Nanao K, Tahara M, Sato W, Takada G, Miura M, Uyemura K (Jan 1992). "Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin".Biochem Biophys Res Commun.181(1): 204–7.doi:10.1016/S0006-291X(05)81402-0.PMID 1720307.
^Hayasaka K, Himoro M, Takada G, Takahashi E, Minoshima S, Shimizu N (Feb 1994). "Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2)".Genomics.18(2): 244–8.doi:10.1006/geno.1993.1462.PMID 8288226.
^"Entrez Gene: PMP2 peripheral myelin protein 2".

Narayanan V, Barbosa E, Reed R, Tennekoon G (1988)."Characterization of a cloned cDNA encoding rabbit myelin P2 protein".J. Biol. Chem.263(17): 8332–7.doi:10.1016/S0021-9258(18)68481-9.PMID 2453513.
Jones TA, Bergfors T, Sedzik J, Unge T (1988)."The three-dimensional structure of P2 myelin protein".EMBO J.7(6): 1597–604.doi:10.1002/j.1460-2075.1988.tb02985.x.PMC457142.PMID 2458918.
Ishaque A, Hofmann T, Eylar EH (1982)."The complete amino acid sequence of the rabbit P2 protein".J. Biol. Chem.257(2): 592–5.doi:10.1016/S0021-9258(19)68231-1.PMID 6172423.
Suzuki M, Kitamura K, Sakamoto Y, Uyemura K (1983). "The complete amino acid sequence of human P2 protein".J. Neurochem.39(6): 1759–62.doi:10.1111/j.1471-4159.1982.tb08017.x.PMID 6183401.S2CID 43779591.
Trapp BD, Dubois-Dalcq M, Quarles RH (1984). "Ultrastructural localization of P2 protein in actively myelinating rat Schwann cells".J. Neurochem.43(4): 944–8.doi:10.1111/j.1471-4159.1984.tb12828.x.PMID 6206203.S2CID 37059056.
Narayanan V, Ripepi B, Jabs EW, et al. (1994)."Partial structure and mapping of the human myelin P2 protein gene"(PDF).J. Neurochem.63(6): 2010–3.doi:10.1046/j.1471-4159.1994.63062010.x.hdl:2027.42/65484.PMID 7525873.S2CID 17388921.
Besançon R, Latour P, Lara K, et al. (2001). "Exonic SNPs at positions 220 (A/G) and 445 (C/T) of the peripheral myelin protein 2 (PMP2)".Hum. Mutat.17(3): 237.doi:10.1002/humu.11.PMID 11241848.S2CID 33419662.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID 12477932.
Fortna A, Kim Y, MacLaren E, et al. (2006)."Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution".PLoS Biol.2(7): E207.doi:10.1371/journal.pbio.0020207.PMC449870.PMID 15252450.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID 15489334.

This article on ageneon humanchromosome 8is astub.You can help Wikipedia byexpanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147588–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052468–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1720307-5] Hayasaka K, Nanao K, Tahara M, Sato W, Takada G, Miura M, Uyemura K (Jan 1992). "Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin".Biochem Biophys Res Commun.181(1): 204–7.doi:10.1016/S0006-291X(05)81402-0.PMID 1720307.

[pmid8288226-6] Hayasaka K, Himoro M, Takada G, Takahashi E, Minoshima S, Shimizu N (Feb 1994). "Structure and localization of the gene encoding human peripheral myelin protein 2 (PMP2)".Genomics.18(2): 244–8.doi:10.1006/geno.1993.1462.PMID 8288226.

[entrez-7] "Entrez Gene: PMP2 peripheral myelin protein 2".

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v t e Protein:cellmembrane proteins(other thanCell surface receptor,enzymes,andcytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see alsoother cell membrane protein disorders

References

Further reading