PPARGC1B
Appearance
Peroxisome proliferator-activated receptor gamma coactivator 1-betais aproteinthat in humans is encoded by thePPARGC1Bgene.[5][6][7]
See also
[edit]- PPARGC1A
- Peroxisome proliferator-activated receptor
- Peroxisome proliferator-activated receptor Alpha
- Peroxisome proliferator-activated receptor delta
- Peroxisome proliferator-activated receptor gamma
- Transcription coregulator
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000155846–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000033871–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O (Jan 2002)."Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus".Diabetologia.44(12): 2220–6.doi:10.1007/s001250100032.PMID11793024.
- ^Kressler D, Schreiber SN, Knutti D, Kralli A (Apr 2002)."The PGC-1-related protein PERC is a selective coactivator of estrogen receptor Alpha".J Biol Chem.277(16): 13918–25.doi:10.1074/jbc.M201134200.PMID11854298.
- ^"Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta".
Further reading
[edit]- Handschin C, Spiegelman BM (2007)."Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism".Endocr. Rev.27(7): 728–35.doi:10.1210/er.2006-0037.PMID17018837.
- Esterbauer H, Oberkofler H, Krempler F, Patsch W (2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression".Genomics.62(1): 98–102.doi:10.1006/geno.1999.5977.PMID10585775.
- Knutti D, Kaul A, Kralli A (2000)."A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen".Mol. Cell. Biol.20(7): 2411–22.doi:10.1128/MCB.20.7.2411-2422.2000.PMC85422.PMID10713165.
- Lin J, Puigserver P, Donovan J, et al. (2002)."Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor".J. Biol. Chem.277(3): 1645–8.doi:10.1074/jbc.C100631200.PMID11733490.
- Lacquemant C, Chikri M, Boutin P, et al. (2002). "No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians".Diabetologia.45(4): 602–3, author reply 604.doi:10.1007/s00125-002-0783-z.PMID12032643.
- Hara K, Tobe K, Okada T, et al. (2003)."A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes".Diabetologia.45(5): 740–3.doi:10.1007/s00125-002-0803-z.PMID12107756.
- Huss JM, Kopp RP, Kelly DP (2002)."Peroxisome proliferator-activated receptor coactivator-1 Alpha (PGC-1 Alpha ) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor- Alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1 Alpha".J. Biol. Chem.277(43): 40265–74.doi:10.1074/jbc.M206324200.PMID12181319.
- Hentschke M, Süsens U, Borgmeyer U (2003). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma".Biochem. Biophys. Res. Commun.299(5): 872–9.doi:10.1016/S0006-291X(02)02753-5.PMID12470660.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Shiraki T, Sakai N, Kanaya E, Jingami H (2003)."Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 Alpha. A possible link between xenobiotic response and nutritional state".J. Biol. Chem.278(13): 11344–50.doi:10.1074/jbc.M212859200.PMID12551939.
- Hammarstedt A, Jansson PA, Wesslau C, et al. (2003). "Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance".Biochem. Biophys. Res. Commun.301(2): 578–82.doi:10.1016/S0006-291X(03)00014-7.PMID12565902.
- Meirhaeghe A, Crowley V, Lenaghan C, et al. (2003)."Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo".Biochem. J.373(Pt 1): 155–65.doi:10.1042/BJ20030200.PMC1223480.PMID12678921.
- Patti ME, Butte AJ, Crunkhorn S, et al. (2003)."Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1".Proc. Natl. Acad. Sci. U.S.A.100(14): 8466–71.Bibcode:2003PNAS..100.8466P.doi:10.1073/pnas.1032913100.PMC166252.PMID12832613.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
- Ling C, Poulsen P, Carlsson E, et al. (2004)."Multiple environmental and genetic factors influence skeletal muscle PGC-1 Alpha and PGC-1beta gene expression in twins".J. Clin. Invest.114(10): 1518–26.doi:10.1172/JCI21889.PMC525741.PMID15546003.
- Andersen G, Wegner L, Yanagisawa K, et al. (2006)."Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity".J. Med. Genet.42(5): 402–7.doi:10.1136/jmg.2004.026278.PMC1736055.PMID15863669.
- Staiger H, Staiger K, Haas C, et al. (2005)."Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1 Alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro".Diabetologia.48(10): 2115–8.doi:10.1007/s00125-005-1895-z.PMID16132959.
- Wirtenberger M, Tchatchou S, Hemminki K, et al. (2006)."Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer".Carcinogenesis.27(11): 2201–8.doi:10.1093/carcin/bgl067.PMID16704985.
External links
[edit]- PPARGC1B protein, humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
- NURSAC21
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.