Pascolizumab
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From Wikipedia, the free encyclopedia
Monoclonal antibody
Monoclonal antibody | |
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Type | Whole antibody |
Source | Humanized(frommouse) |
Target | IL-4 |
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Pascolizumabis ahumanized monoclonal antibodyfor the treatment ofasthma.[1]A Phase IIclinical trialin patients with symptomaticglucocorticoidnaive asthma was conducted in 2001/2002.[2]Development was discontinued as it showed little benefit.[3]
References
[edit]- ^Hart TK, Blackburn MN, Brigham-Burke M, Dede K, Al-Mahdi N, Zia-Amirhosseini P, Cook RM (October 2002)."Preclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthma".Clinical and Experimental Immunology.130(1): 93–100.doi:10.1046/j.1365-2249.2002.01973.x.PMC1906490.PMID12296858.
- ^Clinical trial numberNCT00024544for "Pilot Study in Patients With Symptomatic Steroid-Naive Asthma" atClinicalTrials.gov
- ^Bice JB, Leechawengwongs E, Montanaro A (2014). "Biologic targeted therapy in allergic asthma".Annals of Allergy, Asthma & Immunology.112(2): 108 - 115.doi:10.1016/j.anai.2013.12.013.
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Intracellular (reception) |
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Extracellular |
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Unsorted |
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IL-1 |
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IL-2 | |||||
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IL-4 |
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IL-5 |
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IL-6 |
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IL-7 |
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IL-8 |
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IL-9 |
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IL-10 |
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IL-11 |
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IL-12 |
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IL-13 |
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IL-15 |
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IL-17 |
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IL-18 |
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IL-20 |
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IL-21 |
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IL-22 |
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IL-23 |
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IL-27 |
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IL-31 |
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IL1RL1 |
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IL1RL2 |
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Others |
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