Paul M. Allen
Paul M. Allen | |
|---|---|
| Born | Paul Malone Allen September 1951 |
| Citizenship | American |
| Alma mater | University of Michigan |
| Scientific career | |
| Fields | cellular immunologist |
| Institutions | Washington University in St. Louis |
| Thesis | Functional and serological examination of the central portion of the I region of the H-2 gene complex |
| Doctoral advisor | John Niederhuber |
Paul Malone Allen(born September 1951) is an American cellularimmunologistand current Robert L. Kroc Professor of Pathology and Immunology atWashington University School of MedicineinSt. Louis.Allen holds prestigious MERIT status with the National Institutes of Health.
Education and career
[edit]Paul Allen received hisbachelor'sdegree in 1974 from theUniversity of Michiganfollowed by amaster'sdegree in 1977 and adoctoral degreein 1981 withJohn Niederhuberand a thesis titled "Functional and serological examination of the central portion of the I region of the H-2 gene complex", both from the University of Michigan.[1][2][3]He completed a pathology research fellowship at Harvard Medical School withEmil Unanueand joined the Washington University faculty in 1985.[1]
From 2005 to 2006, Allen served as the president of theAmerican Association of Immunologists.[4]He is a member of the editorial board forImmunity.
Research
[edit]Allen's work specializes in the study of howT lymphocytesrecognizeantigensand initiate animmune response.He andEmil R. Unanuewere responsible for the discovery thatantigen-presenting cellspresent antigens to bind to a special group of molecules known as themajor histocompatibility complex.[1]
Notable works
[edit]- Wipke BT, Allen PM (2001). Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis.Journal of Immunology.167(3): pgs. 1601-1608
- Kersh EN, Shaw AS, Allen PM (1998). Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation.Science.281(5376): pgs. 572-575
- Kersh GJ, Allen PM (1996). Essential flexibility in the T-cell recognition of antigen.Nature.380(6574): pgs. 495-498
- Sloan-Lancaster J, Shaw AS... Allen PM (1994). Partial T cell signalling: Altered phospho-ζ and lack of zap70 recruitment in APL-induced T cell anergy.Cell.79(5): pgs. 913-922
- Sloan-Lancaster J, Evavold BD, Allen PM (1993). Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells.Nature.363(6425): pgs. 156-159
- Evavold BD, Allen PM (1991). Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand.Science.252(5010): pgs. 1308-1310
- Unanue ER, Allen PM (1987). The basis for the immunoregulatory role of macrophages and other accessory cells.Science.236(4801): pgs. 551-557
References
[edit]- ^abcAllen, Paul M. (2006)."Defining Yourself: Tolerance Development in the Immune System".The Journal of Immunology.177(3): 1369–1372.doi:10.4049/jimmunol.177.3.1369.PMID16849437.
- ^"Paul Allen, PhD".Washington University School of Medicine.Retrieved15 July2019.
- ^ProQuest Dissertations and Theses - Paul Malone Allen(Ph.D). 1981.ProQuest303128284.Retrieved15 July2019– via ProQuest.
- ^"Paul M. Allen, PhD".AAI.Retrieved15 July2019.
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