Oxycodone/paracetamol
| Combination of | |
|---|---|
| Oxycodone | Opioid analgesic |
| Acetaminophen | Anilide analgesic |
| Clinical data | |
| Trade names | Percocet, others |
| AHFS/Drugs | Professional Drug Facts |
| License data | |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| ChemSpider | |
| KEGG | |
| CompTox Dashboard(EPA) | |
  (what is this?)(verify) | |
Oxycodone/paracetamol,sold under the brand namePercocetamong others, is afixed-dose combinationof the opioidoxycodonewithparacetamol(acetaminophen), used to treat moderate to severepain.[1]
In 2021, it was the 75th most commonly prescribed medication in theUnited States,with more than 8million prescriptions.[2][3]
History
[edit]The United StatesFood and Drug Administration(FDA) first approved Percocet in 1976, under application ANDA 085106.[4]
Society and culture
[edit]Implicated in deaths
[edit]In June 2009, an FDA advisory panel recommended that Percocet,Vicodin,and every other combination of acetaminophen withnarcoticanalgesics[5]be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed toacetaminophen overdoseand associated liver damage.[6]
In December 2009, theCanadian Medical Association Journalreported a study finding a fivefold increase in oxycodone-related deaths inOntario(mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related deaths in Ontario over the same period.[7][8][9]
In March 2017, US PresidentDonald Trumpinitiated theOpioid and Drug Abuse Commission.[10]In July 2017, a draft report was published.[11]
References
[edit]- ^ab"Percocet- oxycodone hydrochloride and acetaminophen tablet".DailyMed.Retrieved17 October2021.
- ^"The Top 300 of 2021".ClinCalc.Archivedfrom the original on 15 January 2024.Retrieved14 January2024.
- ^"Acetaminophen; Oxycodone - Drug Usage Statistics".ClinCalc.Retrieved14 January2024.
- ^"Percocet: FDA-Approved Drugs".U.S.Food and Drug Administration(FDA).Retrieved17 October2021.
- ^"FDA May Restrict Acetaminophen".WebMD.
- ^Harris G (30 June 2009)."Ban Is Advised on 2 Top Pills for Pain Relief".The New York Times.Retrieved22 May2010.
- ^Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN (December 2009)."Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone".CMAJ.181(12): 891–6.doi:10.1503/cmaj.090784.PMC2789126.PMID19969578.
- ^Fischer B, Rehm J (December 2009)."Deaths related to the use of prescription opioids".CMAJ.181(12): 881–2.doi:10.1503/cmaj.091791.PMC2789122.PMID19969577.
- ^"Deaths from opioid use have doubled; five-fold increase in oxycodone deaths".Canadian Medical Association Journal.7 December 2009.Retrieved31 May2012.
- ^"Presidential Executive Order Establishing the President's Commission on Combating Drug Addiction and the Opioid Crisis".29 March 2017. Archived fromthe originalon 30 March 2017.
- ^"Draft interim report"(PDF).The White House.
| pyrazolones/ pyrazolidines | |
|---|---|
| salicylates | |
| acetic acidderivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
|
| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key:underlineindicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;†withdrawn drugs;‡veterinary use. | |
