Glutarimide
Appearance
(Redirected fromPiperidinedione)
Names | |
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Preferred IUPAC name
Piperidine-2,6-dione | |
Other names
2,6-Diketopiperidine
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
ECHA InfoCard | 100.013.038 |
PubChemCID
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UNII | |
CompTox Dashboard(EPA)
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Properties | |
C5H7NO2 | |
Molar mass | 113.11 g/mol |
Melting point | 155-157 °C[1] |
Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa).
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Glutarimideis theorganic compoundwith the formula (CH2)3(CO)2NH. It is a white solid. The compound forms upon dehydration of the amide ofglutaric acid.[2]
Glutarimide is sometimes called 2,6-piperidinedione. It is the core of a variety ofdrugs,includingthalidomide,a medication used to treatmultiple myeloma[3]andleprosy,[4]andcycloheximide,a potent inhibitor of protein synthesis.[5]
References
[edit]- ^Glutarimide-Sigma-Aldrich
- ^Paris, G.; Berlinguet, L.; Gaudry, R.; English, Jr., J.; Dayan, J. E. (1957). "Glutaric Acid and Glutarimide".Organic Syntheses.37:47.doi:10.15227/orgsyn.037.0047.
- ^"A to Z List of Cancer Drugs: Thalidomide".National Cancer Institute.Retrieved20 September2021.
- ^Stolberg SG (17 July 1998)."Thalidomide Approved to Treat Leprosy, With Other Uses Seen".New York Times.Retrieved20 September2021.
- ^Sisler, Hugh D.; Siegel, Malcolm R. (1967)."Cycloheximide and Other Glutarimide Antibiotics".Mechanism of Action.pp. 283–307.doi:10.1007/978-3-642-46051-7_21.ISBN978-3-642-46053-1.