Piperidione
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| Trade names | Ascron, Dihyprylon, Dihyprylone, Sedulon, Tusseval |
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| ECHA InfoCard | 100.000.909 |
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| Formula | C9H15NO2 |
| Molar mass | 169.224g·mol−1 |
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Piperidione(trade nameSedulon) is asedativedrug, structurally related tomethyprylonandpyrithyldione. It used to be marketed byRocheas acough medicineavailable in liquid form.[1][2][3]In the US, it was approved by the FDA on grounds of safety alone in 1947. After Roche failed to submit evidence of efficacy to theDrug Efficacy Study Implementationprogram in 1972, it was withdrawn from the US market.[4]
See also
[edit]References
[edit]- ^Wolff PO (1949)."On pethidine and methadone derivatives".Bulletin of the World Health Organization.2(2): 193–204.PMC2553950.PMID15409516.
- ^Jacobs S (October 1948). "The use of piperidione as a cough sedative".Medical Times.76(10): 445–7.PMID18102053.
- ^Rimoldi R, Fioretti M, Bandella M (February 1985). "[Use of an antitussive drug in pulmonary pathology]".Bollettino Chimico Farmaceutico.124(2): 1S–6S.PMID3839404.
- ^Certain Preparations Containing Dihyprylone or Pipazethate Hydrochloride; Notice of Withdrawal of Approval of New-Drug Applications(PDF).Federal Register(Report). Vol. 37. August 5, 1972. p. 15887. FDC–D–458.
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