SIB-1893
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Formula | C14H13N |
Molar mass | 195.265g·mol−1 |
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SIB-1893is a drug used in scientific research which was one of the first compounds developed that acts as a selectiveantagonistfor themetabotropic glutamate receptorsubtypemGluR5.[1]It hasanticonvulsantandneuroprotectiveeffects,[2]and reduces glutamate release.[3]It has also been found to act as a positive allosteric modulator ofmGluR4.[4]
References
[edit]- ^Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Veliçelebi G, Johnson EC (July 1999). "SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5".The Journal of Pharmacology and Experimental Therapeutics.290(1): 170–81.PMID10381773.
- ^Chapman AG, Nanan K, Williams M, Meldrum BS (July 2000). "Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)".Neuropharmacology.39(9): 1567–74.doi:10.1016/S0028-3908(99)00242-7.PMID10854901.S2CID21528282.
- ^Wang SJ, Sihra TS (June 2004). "Noncompetitive metabotropic glutamate5 receptor antagonist (E)-2-methyl-6-styryl-pyridine (SIB1893) depresses glutamate release through inhibition of voltage-dependent Ca2+ entry in rat cerebrocortical nerve terminals (synaptosomes)".The Journal of Pharmacology and Experimental Therapeutics.309(3): 951–8.doi:10.1124/jpet.103.064881.PMID14982967.S2CID800526.
- ^Mathiesen JM, Svendsen N, Bräuner-Osborne H, Thomsen C, Ramirez MT (March 2003)."Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP".British Journal of Pharmacology.138(6): 1026–30.doi:10.1038/sj.bjp.0705159.PMC1573757.PMID12684257.