SNRPD3

SNRPD3
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 1D3B,3CW1,3PGW,3VRI,4PJO,4WZJ,3JCR
Identifiers
Aliases	SNRPD3,SMD3, Sm-D3, small nuclear ribonucleoprotein D3 polypeptide
External IDs	OMIM:601062;MGI:1914582;HomoloGene:3078;GeneCards:SNRPD3;OMA:SNRPD3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.23 Start 24,555,958bp End 24,582,052bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 75,353,385bp End 75,373,215bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in ganglionic eminence islet of Langerhans ventricular zone white blood cell monocyte appendix muscle of thigh granulocyte olfactory zone of nasal mucosa duodenum Top expressed in abdominal wall otic placode ventricular zone somite migratory enteric neural crest cell mandibular prominence maxillary prominence endocardial cushion dermis hand More reference expression data BioGPS n/a
Gene ontology Molecular function histone pre-mRNA DCP binding U2 snRNA binding protein binding enzyme binding U7 snRNA binding telomerase RNA binding U1 snRNP binding RNA binding Cellular component SMN-Sm protein complex cytosol prespliceosome catalytic step 2 spliceosome spliceosomal tri-snRNP complex U5 snRNP U12-type spliceosomal complex U2 snRNP nucleoplasm methylosome U7 snRNP precatalytic spliceosome small nuclear ribonucleoprotein complex pICln-Sm protein complex telomerase holoenzyme complex spliceosomal complex commitment complex U4 snRNP extracellular exosome nucleus U1 snRNP cytoplasm nuclear body U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription RNA processing mRNA processing spliceosomal complex assembly RNA splicing histone mRNA metabolic process protein methylation import into nucleus spliceosomal snRNP assembly Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 6634 67332 Ensembl ENSG00000100028 ENSMUSG00000020180 UniProt P62318 P62320 RefSeq (mRNA) NM_001278656 NM_004175 NM_026095 RefSeq (protein) NP_001265585 NP_004166 NP_080371 Location (UCSC) Chr 22: 24.56 – 24.58 Mb Chr 10: 75.35 – 75.37 Mb PubMedsearch
Wikidata
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Small nuclear ribonucleoprotein Sm D3is aproteinthat in humans is encoded by theSNRPD3gene.

Function

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.

Interactions

SNRPD3 has been shown tointeractwith:

• CDC5L,
• CLNS1A,
• DDX20,and
• Protein arginine methyltransferase 5.

Further reading

• Liu Q, Fischer U, Wang F, Dreyfuss G (1997)."The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins".Cell.90(6): 1013–21.doi:10.1016/S0092-8674(00)80367-0.PMID9323129.
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins".Exp. Cell Res.237(1): 63–9.doi:10.1006/excr.1997.3750.PMID9417867.
• Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (1999)."Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs".Cell.96(3): 375–87.doi:10.1016/S0092-8674(00)80550-4.PMID10025403.
• Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (2000)."Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems".J. Cell Biol.147(6): 1181–94.doi:10.1083/jcb.147.6.1181.PMC2168095.PMID10601333.
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (2000)."Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli".J. Cell Biol.148(6): 1177–86.doi:10.1083/jcb.148.6.1177.PMC2174312.PMID10725331.
• Brahms H, Raymackers J, Union A, de Keyser F, Meheus L, Lührmann R (2000)."The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies".J. Biol. Chem.275(22): 17122–9.doi:10.1074/jbc.M000300200.hdl:11858/00-001M-0000-0012-F7F0-E.PMID10747894.
• Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (2001)."Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry".EMBO J.19(23): 6569–81.doi:10.1093/emboj/19.23.6569.PMC305846.PMID11101529.
• Urlaub H, Raker VA, Kostka S, Lührmann R (2001)."Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure".EMBO J.20(1–2): 187–96.doi:10.1093/emboj/20.1.187.PMC140196.PMID11226169.
• Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G (2001)."SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets".Mol. Cell.7(5): 1111–7.doi:10.1016/S1097-2765(01)00244-1.PMID11389857.
• Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (2001)."The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins".Mol. Cell. Biol.21(24): 8289–300.doi:10.1128/MCB.21.24.8289-8300.2001.PMC99994.PMID11713266.
• Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002)."Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins".J. Biol. Chem.277(7): 5631–6.doi:10.1074/jbc.M109448200.PMID11714716.
• Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U (2002). "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln".Curr. Biol.11(24): 1990–4.doi:10.1016/S0960-9822(01)00592-9.hdl:11858/00-001M-0000-0012-F501-7.PMID11747828.S2CID14742376.
• Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (2002)."Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component".J. Biol. Chem.277(9): 7540–5.doi:10.1074/jbc.M110141200.PMID11748230.
• Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002)."A novel WD repeat protein component of the methylosome binds Sm proteins".J. Biol. Chem.277(10): 8243–7.doi:10.1074/jbc.M109984200.PMID11756452.
• Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation".Nature.414(6866): 929–33.doi:10.1038/414929a.PMID11780068.S2CID1518837.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002)."Directed proteomic analysis of the human nucleolus".Curr. Biol.12(1): 1–11.doi:10.1016/S0960-9822(01)00650-9.PMID11790298.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002)."Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis".RNA.8(4): 426–39.doi:10.1017/S1355838202021088.PMC1370266.PMID11991638.
• Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002)."Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex".J. Biol. Chem.277(35): 31957–62.doi:10.1074/jbc.M203478200.PMID12065586.