SNRPD3
Appearance
Small nuclear ribonucleoprotein Sm D3is aproteinthat in humans is encoded by theSNRPD3gene.[5][6][7]
Function
[edit]The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.[7]
Interactions
[edit]SNRPD3 has been shown tointeractwith:
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000100028–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000020180–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Lehmeier T, Foulaki K, Lührmann R (January 1991)."Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5".Nucleic Acids Res.18(22): 6475–84.doi:10.1093/nar/18.22.6475.PMC332598.PMID1701240.
- ^Lehmeier T, Raker V, Hermann H, Lührmann R (January 1995)."cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction".Proc Natl Acad Sci U S A.91(25): 12317–21.Bibcode:1994PNAS...9112317L.doi:10.1073/pnas.91.25.12317.PMC45428.PMID7527560.
- ^ab"Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa".
- ^Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000)."Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry".EMBO J.19(23): 6569–81.doi:10.1093/emboj/19.23.6569.PMC305846.PMID11101529.
- ^abFriesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G,Rappsilber J,Mann M, Dreyfuss G (Dec 2001)."The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins".Mol. Cell. Biol.21(24): 8289–300.doi:10.1128/MCB.21.24.8289-8300.2001.PMC99994.PMID11713266.
- ^Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999)."Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems".J. Cell Biol.147(6): 1181–94.doi:10.1083/jcb.147.6.1181.PMC2168095.PMID10601333.
Further reading
[edit]- Liu Q, Fischer U, Wang F, Dreyfuss G (1997)."The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins".Cell.90(6): 1013–21.doi:10.1016/S0092-8674(00)80367-0.PMID9323129.
- Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins".Exp. Cell Res.237(1): 63–9.doi:10.1006/excr.1997.3750.PMID9417867.
- Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (1999)."Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs".Cell.96(3): 375–87.doi:10.1016/S0092-8674(00)80550-4.PMID10025403.
- Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (2000)."Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems".J. Cell Biol.147(6): 1181–94.doi:10.1083/jcb.147.6.1181.PMC2168095.PMID10601333.
- Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (2000)."Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli".J. Cell Biol.148(6): 1177–86.doi:10.1083/jcb.148.6.1177.PMC2174312.PMID10725331.
- Brahms H, Raymackers J, Union A, de Keyser F, Meheus L, Lührmann R (2000)."The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies".J. Biol. Chem.275(22): 17122–9.doi:10.1074/jbc.M000300200.hdl:11858/00-001M-0000-0012-F7F0-E.PMID10747894.
- Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (2001)."Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry".EMBO J.19(23): 6569–81.doi:10.1093/emboj/19.23.6569.PMC305846.PMID11101529.
- Urlaub H, Raker VA, Kostka S, Lührmann R (2001)."Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure".EMBO J.20(1–2): 187–96.doi:10.1093/emboj/20.1.187.PMC140196.PMID11226169.
- Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G (2001)."SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets".Mol. Cell.7(5): 1111–7.doi:10.1016/S1097-2765(01)00244-1.PMID11389857.
- Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (2001)."The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins".Mol. Cell. Biol.21(24): 8289–300.doi:10.1128/MCB.21.24.8289-8300.2001.PMC99994.PMID11713266.
- Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002)."Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins".J. Biol. Chem.277(7): 5631–6.doi:10.1074/jbc.M109448200.PMID11714716.
- Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U (2002). "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln".Curr. Biol.11(24): 1990–4.doi:10.1016/S0960-9822(01)00592-9.hdl:11858/00-001M-0000-0012-F501-7.PMID11747828.S2CID14742376.
- Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (2002)."Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component".J. Biol. Chem.277(9): 7540–5.doi:10.1074/jbc.M110141200.PMID11748230.
- Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002)."A novel WD repeat protein component of the methylosome binds Sm proteins".J. Biol. Chem.277(10): 8243–7.doi:10.1074/jbc.M109984200.PMID11756452.
- Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation".Nature.414(6866): 929–33.doi:10.1038/414929a.PMID11780068.S2CID1518837.
- Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002)."Directed proteomic analysis of the human nucleolus".Curr. Biol.12(1): 1–11.doi:10.1016/S0960-9822(01)00650-9.PMID11790298.
- Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002)."Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis".RNA.8(4): 426–39.doi:10.1017/S1355838202021088.PMC1370266.PMID11991638.
- Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002)."Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex".J. Biol. Chem.277(35): 31957–62.doi:10.1074/jbc.M203478200.PMID12065586.