SPRR2A

SPRR2A
Identifiers
Aliases	SPRR2A,small proline rich protein 2A
External IDs	OMIM:182267;MGI:1330343;HomoloGene:130544;GeneCards:SPRR2A;OMA:SPRR2A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,057,512bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	92,294,631bp
RNA expressionpattern
	Top expressed in
	buccal mucosa cell; ; gums; ; gingival epithelium; ; body of tongue; ; amniotic fluid; ; mucosa of pharynx; ; oral cavity; ; human penis; ; nasal epithelium; ; vulva;
	Top expressed in
	gastrula; ; decidua; ; cervix; ; skin of back; ; lip; ; skin of abdomen; ; skin of external ear; ; belly cord; ; sexually immature organism; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; structural molecule activity;
Cellular component	cytoplasm; cornified envelope; cytosol;
Biological process	peptide cross-linking; keratinization; keratinocyte differentiation; epidermis development; cornification;
	Sources:Amigo/QuickGO
Orthologs
	6700
	20762
	ENSG00000241794
	ENSMUSG00000046259
	P35326
	O70559
	NM_005988
	NM_011474
	NP_005979
	NP_035604
	Wikidata
View/Edit Human	View/Edit Mouse

Small proline-rich protein 2Ais aproteinthat in humans is encoded by theSPRR2Agene.^[5]^[6]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000241794–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000046259–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (Aug 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins".Genomics.16(3): 630–7.doi:10.1006/geno.1993.1240.PMID 8325635.
^"Entrez Gene: SPRR2A small proline-rich protein 2A".

Gregory SG, Barlow KF, McLay KE, et al. (2006)."The DNA sequence and biological annotation of human chromosome 1".Nature.441(7091): 315–21.Bibcode:2006Natur.441..315G.doi:10.1038/nature04727.PMID 16710414.
Tong L, Corrales RM, Chen Z, et al. (2006)."Expression and Regulation of Cornified Envelope Proteins in Human Corneal Epithelium".Invest. Ophthalmol. Vis. Sci.47(5): 1938–46.doi:10.1167/iovs.05-1129.PMC2906387.PMID 16639001.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID 15489334.
Hong SH, Nah HY, Lee JY, et al. (2004)."Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus".Mol. Cells.17(3): 477–84.doi:10.1016/S1016-8478(23)13069-X.PMID 15232223.
Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003)."Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation".J. Biol. Chem.278(20): 17792–9.doi:10.1074/jbc.M300508200.hdl:1887/50054.PMID 12624109.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID 12477932.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000)."Shotgun sequencing of the human transcriptome with ORF expressed sequence tags".Proc. Natl. Acad. Sci. U.S.A.97(7): 3491–6.Bibcode:2000PNAS...97.3491D.doi:10.1073/pnas.97.7.3491.PMC16267.PMID 10737800.
Fischer DF, van Drunen CM, Winkler GS, et al. (1999)."Involvement of a nuclear matrix association region in the regulation of the SPRR2A keratinocyte terminal differentiation marker".Nucleic Acids Res.26(23): 5288–94.doi:10.1093/nar/26.23.5288.PMC147987.PMID 9826750.
Steinert PM, Marekov LN (1997)."Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope".J. Biol. Chem.272(3): 2021–30.doi:10.1074/jbc.272.3.2021.PMID 8999895.
Fischer DF, Gibbs S, van De Putte P, Backendorf C (1996)."Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation".Mol. Cell. Biol.16(10): 5365–74.doi:10.1128/MCB.16.10.5365.PMC231535.PMID 8816448.
Gibbs S, Lohman F, Teubel W, et al. (1990)."Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes".Nucleic Acids Res.18(15): 4401–7.doi:10.1093/nar/18.15.4401.PMC331257.PMID 2388825.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000241794–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046259–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8325635-5] Gibbs S, Fijneman R, Wiegant J, van Kessel AG, van De Putte P, Backendorf C (Aug 1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins".Genomics.16(3): 630–7.doi:10.1006/geno.1993.1240.PMID 8325635.

[entrez-6] "Entrez Gene: SPRR2A small proline-rich protein 2A".

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References

Further reading