Selective receptor modulator
| Selective receptor modulator | |
|---|---|
| Drug class | |
 | |
| Class identifiers | |
| Synonyms | SRM |
| Use | Various |
| Biological target | Steroid hormone receptor |
| Chemical class | Steroidal;Nonsteroidal |
| Legal status | |
| In Wikidata | |
In the field ofpharmacology,aselective receptor modulatororSRMis a type ofdrugthat has different effects in different tissues.[1]A SRM may behave as anagonistin some tissues while as anantagonistin others. Hence selective receptor modulators are sometimes referred to astissue selective drugsormixed agonists / antagonists.This tissue selective behavior is in contrast to many other drugs that behave either as agonists or antagonists regardless of the tissue in question.
Classes
[edit]Classes of selective receptor modulators include:
- Selective androgen receptor modulator(SARM)
- Selective estrogen receptor modulator(SERM)
- Selective glucocorticoid receptor modulator(SEGRM)
- Selective progesterone receptor modulator(SPRM)
- Selective PPAR modulator(SPPARM) including SPPARMγ (affecting thePPARγ) and SPPARMα (PPARα)
See also
[edit]References
[edit]- ^Smith CL, O'Malley BW (February 2004)."Coregulator function: a key to understanding tissue specificity of selective receptor modulators".Endocr. Rev.25(1): 45–71.doi:10.1210/er.2003-0023.PMID14769827.
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