Small nucleolar RNA SNORA50
| Small nucleolar RNA SNORA50 | |
|---|---|
 Predictedsecondary structureandsequence conservationof SNORA50 | |
| Identifiers | |
| Symbol | SNORA50 |
| Alt. Symbols | snoACA50 |
| Rfam | RF00407 |
| Other data | |
| RNAtype | Gene;snRNA;snoRNA;HACA-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396GO:0005730 |
| SO | SO:0001263 |
| PDBstructures | PDBe |
Inmolecular biology,Small nucleolar RNA SNORA50(also known as ACA50) is anon-coding RNA(ncRNA) molecule which functions in the biogenesis (modification) of othersmall nuclear RNAs(snRNAs). This type of modifying RNA is located in the nucleolus of theeukaryoticcell which is a major site of snRNA biogenesis. It is known as asmall nucleolar RNA(snoRNA) and also often referred to as a 'guide RNA'. ACA50 was originally cloned fromHeLacells[1]and belongs to theH/ACA boxclass of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA50 is predicted to guide the pseudouridylation of U34 and U105 of 18Sribosomal RNA(rRNA). Pseudouridylation is the (isomerisationof the nucleosideuridine) to the different isomeric formpseudouridine.
References
[edit]- ^Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004)."Human box H/ACA pseudouridylation guide RNA machinery".Molecular and Cellular Biology.24(13): 5797–807.doi:10.1128/MCB.24.13.5797-5807.2004.PMC480876.PMID15199136.
External links
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