Small nucleolar RNA SNORD48
| Small nucleolar RNA SNORD48 | |
|---|---|
 Predictedsecondary structureandsequence conservationof SNORD48 | |
| Identifiers | |
| Symbol | SNORD48 |
| Alt. Symbols | U48 |
| Rfam | RF00282 |
| Other data | |
| RNAtype | Gene;snRNA;snoRNA;C/D-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396GO:0005730 |
| SO | SO:0000593 |
| PDBstructures | PDBe |
Inmolecular biology,SNORD48(also known asU48) is anon-coding RNA(ncRNA) molecule which functions in the modification of othersmall nuclear RNAs(snRNAs). This type of modifying RNA is usually located in thenucleolusof the eukaryotic cell which is a major site of snRNA biogenesis. It is known as asmall nucleolar RNA(snoRNA) and also often referred to as a guide RNA.
U48 belongs to theC/D boxclass of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylationof substrate RNAs.[1]
This snoRNA was originally cloned fromHeLacells and experimentally verified bynorthern blotting.[2]SNORD48 is predicted to guide the 2'O-ribose methylation of 28S rRNA C2279.[3]In the human genome this snoRNA is located in theintronsof the same host gene (C6orf48) as another C/D boxsnoRNA U52(also known as SNORD52).[3]
References
[edit]- ^Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002)."Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro".Molecular and Cellular Biology.22(19): 6663–8.doi:10.1128/MCB.22.19.6663-6668.2002.PMC134041.PMID12215523.
- ^Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (June 1996)."Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs".Cell.85(7): 1077–88.doi:10.1016/S0092-8674(00)81308-2.PMID8674114.S2CID10418885.
- ^abLestrade L, Weber MJ (January 2006)."snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs".Nucleic Acids Research.34(Database issue): D158-62.CiteSeerX10.1.1.105.7552.doi:10.1093/nar/gkj002.PMC1347365.PMID16381836.
External links
[edit]- Page for Small nucleolar RNA SNORD48atRfam
- Entry for SNORD52atsnoRNABase
- Entry for SNORD48atsnoRNABase
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