Sodium glycerophosphate
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| Clinical data | |
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| Trade names | Glycophos |
| AHFS/Drugs | Professional Drug Facts |
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| Routes of administration | Intravenous infusion |
| ATC code | |
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| Identifiers | |
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| Chemical and physical data | |
| Formula | C3H7Na2O6P |
| Molar mass | 216.036g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 98 to 100 °C (208 to 212 °F) |
| Solubility in water | very soluble |
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Sodium glycerophosphate,sold under the brand nameGlycophos,is a medication used to supplementphosphate.[3][4]It is administered viaintravenous infusion.[3][4]
Sodium glycerophosphate is an organic phosphate salt.[3][4]
It was approved for medical use in Australia in November 2019.[5][3][6]
It is an unapproved medication in the United States that was used as a substitute for inorganic phosphate during a drug shortage.[4]
Chemistry
[edit]The substance is a mixture of disodiumglycerol1- and 2-phosphates,which have different amounts ofwater of crystallization;the total amount is5+1⁄2H2O per glycerol phosphate molecule. It is a white to off-white powder which may or may not be crystalline, has no discernible odor and tastes salty. It melts at 98 to 100 °C (208 to 212 °F) and decomposes at 130 °C (266 °F).Aqueous solutionshave apHof about 9.5.[7]
References
[edit]- ^"Glycophos APMDS".Therapeutic Goods Administration (TGA).26 May 2022.Retrieved10 March2024.
- ^"Australian Public Assessment Report for Sodium glycerophosphate (as hydrate)"(PDF).Therapeutic Goods Administration(TGA).
- ^abcd"ARTG Entry:312021 Glycophos Product Information"(PDF).Therapeutic Goods Administration(TGA).Retrieved23 August2020.
- ^abcd"Glycophos- sodium glycolate injection, solution".DailyMed.16 January 2019.Retrieved23 August2020.
- ^"Glycophos Australian prescription medicine decision summary".Therapeutic Goods Administration(TGA).Retrieved23 August2020.
- ^"Summary for ARTG Entry:312021 Glycophos sodium glycerophosphate (as hydrate) 4.32 g/20 mL concentrated solution for injection ampoule".Therapeutic Goods Administration(TGA).Archived fromthe originalon 18 April 2021.Retrieved23 August2020.
- ^Hagers Handbuch der pharmazeutischen Praxis(in German). Vol. VI.A (4th ed.). Springer. 15 August 1977. pp. 91–92.ISBN3-540-05123-6.
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