Spermatogonium

Spermatogonium
Germinal epithelium of the testicle. 1basal lamina,2 spermatogonia,3spermatocyte1st order, 4 spermatocyte 2nd order, 5spermatid,6 mature spermatid, 7Sertoli cell,8tight junction(blood testis barrier)
Histological section through testicular parenchyma of aboar.1 Lumen ofTubulus seminiferus contortus,2spermatids,3spermatocytes,4 spermatogonia, 5Sertoli cell,6myofibroblasts,7Leydig cells,8capillaries
Identifiers
MeSH	D013093
FMA	72291
Anatomical terminology

Aspermatogonium(pl.:spermatogonia) is an undifferentiated malegerm cell.Spermatogonia undergospermatogenesisto form maturespermatozoain theseminiferous tubulesof thetestis.

There are three subtypes of spermatogonia in humans:

• Type A (dark)cells, with dark nuclei. These cells are reservespermatogonial stem cellswhich do not usually undergo activemitosis.
• Type A (pale)cells, with pale nuclei. These are thespermatogonial stem cellsthat undergo activemitosis.These cells divide to produce Type B cells.
• Type Bcells, which undergo growth and become primaryspermatocytes.

Anticancer drugs

Anticancer drugs such asdoxorubicinandvincristinecan adversely affectmale fertilityby damaging theDNAof proliferative spermatogonialstem cells.Experimental exposure of rat undifferentiated spermatogonia to doxorubicin and vincristine indicated that these cells are able to respond to DNA damage by increasing their expression ofDNA repairgenes, and that this response likely partially prevents DNA break accumulation.In addition to a DNA repair response, exposure of spermatogonia to doxorubicin can also induce programmed cell death (apoptosis).

Additional images

• 
  Transverse section of atubuleof thetestisof arat.X 250.
• 
  Schematic diagram of Spermatocytogenesis Wandimu Geneti

See also

• List of distinct cell types in the adult human body