Sulfoxone

Sulfoxone
Clinical data
Routes of; administration	Oral
ATC code	J04BA03(WHO);
Pharmacokineticdata
Protein binding	69%
Metabolism	Hepatic
Eliminationhalf-life	3 to 8 hours
Identifiers
	IUPAC name [4-[4-(sulfinomethylamino) phenyl] sulfonylphenyl] aminomethanesulfinic acid;
CAS Number	144-75-2;
PubChemCID	8954;
DrugBank	DB01145;
ChemSpider	8610;
UNII	57OWB0Q221;
KEGG	D02521;
ChEMBL	ChEMBL1200580;
CompTox Dashboard(EPA)	DTXSID80162594;
Chemical and physical data
Formula	C14H16N2Na2O6S3
Molar mass	450.45g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Na+].[Na+].[O-]S(=O)CNc1ccc(cc1)S(=O)(=O)c2ccc(NCS([O-])=O)cc2;
	InChI InChI=1S/C14H16N2O6S3.2Na/c17-23(18)9-15-11-1-5-13(6-2-11)25(21,22)14-7-3-12(4-8-14)16-10-24(19)20;;/h1-8,15-16H,9-10H2,(H,17,18)(H,19,20);;/q;2*+1/p-2; Key:AZBNFLZFSZDPQF-UHFFFAOYSA-L;
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Sulfoxoneoraldesulfone sodiumis an anti-leprosydrug.^[1]It is also known asdiasone.Sulfoxone sodium was introduced in Japan in 1948.^[2]Ernest Muirintroduced it to Western use while serving as superintendent of theChacachacare LeprosariumonTrinidadin theCaribbean.^[3]

References

^"Sulfoxone".
^Ozawa H, Maruyama Y (2002). "[A 50-year history of new drugs in Japan: the developments of antileprosy drugs and their epidemiological aspects]".Yakushigaku Zasshi.37(1): 76–83.PMID 12412600.
^Browne, Stanley George (1974),"Ernest Muir, C.M.G., C.I.E., M.D. (Edin.), F.R.C.S., LL.D. 1880–1974"(PDF),International Journal of Leprosy,vol. 42, no. 4,Bauru:International Leprosy Association, pp. 457–458,PMID 4617724.