T-47D
T-47Dis a humanbreast cancercell linecommonly used in biomedical research involving thehormonalexpression of cancer cells.[1]
Characteristics
[edit]The cells were derived from thepleural effusionof aductal carcinomafound in themammary glandof an elderly human patient. T-47D cells are distinct from other human breast cancer cells in that theirprogesterone receptorsare not regulated byestradiol,a hormone that is abundant within the cells themselves.[2]
Usage
[edit]T-47D cells have been employed in studies of the effects ofprogesteroneon breast cancer and the correspondingtranscriptionalregulation caused by introduced drugs.[3]T-47D cells can be implanted intoimmunodeficient mice,formingxenograftsthat can undergo drug testing with corresponding receptor status andangiogenesischanges. The cells have been noted to be extremely resistant toestrogensand antiestrogens, possibly due to inhibition by 5-bromodeoxyuridine and sodium butyrate.[2]
References
[edit]- ^Yu, S; et al. (6 May 2017). "The T47D cell line is an ideal experimental model to elucidate the progesterone-specific effects of a luminal A subtype of breast cancer".Biochemical and Biophysical Research Communications.486(3): 752–758.doi:10.1016/j.bbrc.2017.03.114.PMID28342866.
- ^abHorowitz, Kathryn; et al. (March 1982)."Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance"(PDF).Cell.28(3): 633–642.doi:10.1016/0092-8674(82)90218-5.PMID7200400.S2CID30373148.
- ^Sartorios, Carol; et al. (15 July 1994)."New T47D Breast Cancer Cell Lines for the Independent Study of Progesterone B- and A-Receptors: Only Antiprogestin-occupied B-Receptors Are Switched to Transcriptional Agonists by cAMP'"(PDF).Cancer Research.54(14): 3868–3877.PMID8033109.
External links
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