TAS2R7

TAS2R7
Identifiers
Aliases	TAS2R7,T2R7, TRB4, taste 2 receptor member 7
External IDs	OMIM:604793;MGI:2681278;HomoloGene:41536;GeneCards:TAS2R7;OMA:TAS2R7 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,802,627bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	131,607,875bp
RNA expressionpattern
	Top expressed in
	Achilles tendon;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; taste receptor activity; bitter taste receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; response to stimulus; sensory perception of taste; G protein-coupled receptor signaling pathway;
	Sources:Amigo/QuickGO
Orthologs
	50837
	387355
	ENSG00000121377; ENSG00000273326; ENSG00000274327
	ENSMUSG00000054497
	Q9NYW3
	P59530
	NM_023919
	NM_199156
	NP_076408
	NP_954607
	Wikidata
View/Edit Human	View/Edit Mouse

Taste receptor type 2 member 7is aproteinthat in humans is encoded by theTAS2R7gene.^[5]^[6]^[7]

Function

This gene product belongs to the family of candidatetaste receptorsthat are members of theG-protein-coupled receptorsuperfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in thegenomein clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster onchromosome 12p13.^[7]

References

^^a ^b ^cENSG00000273326, ENSG00000274327 GRCh38: Ensembl release 89: ENSG00000121377, ENSG00000273326, ENSG00000274327–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000054497–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000)."A novel family of mammalian taste receptors".Cell.100(6): 693–702.doi:10.1016/S0092-8674(00)80705-9.PMID 10761934.S2CID 14604586.
^Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse".Nature.404(6778): 601–4.Bibcode:2000Natur.404..601M.doi:10.1038/35007072.PMID 10766242.S2CID 4336913.
^^a ^b"Entrez Gene: TAS2R7 taste receptor, type 2, member 7".

Kinnamon SC (2000)."A plethora of taste receptors".Neuron.25(3): 507–10.doi:10.1016/S0896-6273(00)81054-5.PMID 10774719.
Margolskee RF (2002)."Molecular mechanisms of bitter and sweet taste transduction".J. Biol. Chem.277(1): 1–4.doi:10.1074/jbc.R100054200.PMID 11696554.
Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste".Curr. Opin. Neurobiol.12(4): 366–71.doi:10.1016/S0959-4388(02)00345-8.PMID 12139982.S2CID 37807140.
Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000)."T2Rs function as bitter taste receptors".Cell.100(6): 703–11.doi:10.1016/S0092-8674(00)80706-0.PMID 10761935.S2CID 7293493.
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003)."Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways".Cell.112(3): 293–301.doi:10.1016/S0092-8674(03)00071-0.PMID 12581520.S2CID 718601.
Fischer A, Gilad Y, Man O, Pääbo S (2005)."Evolution of bitter taste receptors in humans and apes".Mol. Biol. Evol.22(3): 432–6.doi:10.1093/molbev/msi027.PMID 15496549.
Go Y, Satta Y, Takenaka O, Takahata N (2006)."Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates".Genetics.170(1): 313–26.doi:10.1534/genetics.104.037523.PMC1449719.PMID 15744053.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.

Thistransmembrane receptor-related article is astub.You can help Wikipedia byexpanding it.

[refGRCh38Ensembl-1] ENSG00000273326, ENSG00000274327 GRCh38: Ensembl release 89: ENSG00000121377, ENSG00000273326, ENSG00000274327–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054497–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10761934-5] Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000)."A novel family of mammalian taste receptors".Cell.100(6): 693–702.doi:10.1016/S0092-8674(00)80705-9.PMID 10761934.S2CID 14604586.

[pmid10766242-6] Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse".Nature.404(6778): 601–4.Bibcode:2000Natur.404..601M.doi:10.1038/35007072.PMID 10766242.S2CID 4336913.

[entrez-7] "Entrez Gene: TAS2R7 taste receptor, type 2, member 7".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

TAS2R7

Function

See also

References

Further reading