TCS-1205
Appearance
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IUPAC name
2-(5-nitro-1H-indol-3-yl)-2-oxo-N-[(1R)-1-phenylethyl]acetamide
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Identifiers | |
3D model (JSmol)
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PubChemCID
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Properties | |
C18H15N3O4 | |
Molar mass | 337.335g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa).
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TCS 1205is an organic chemical compound. It is abenzodiazepine siteagonist selective for certain sub-units.
Pharmacology
[edit]TCS 1205acts at thebenzodiazepinebinding site, it is selective for thea1anda2subunits of theGABAAreceptor.[1]In vivo,it hasanxiolyticeffects but no sedative effects.[2][3]
Chemistry
[edit]Despite acting at thebenzodiazepine receptor,it does not contain thebenzodiazepinestructure, it could therefore be classed as aNonbenzodiazepine.
References
[edit]- ^https://documents.tocris /pdfs/tocris_coa/3941_1_coa.pdf?1706728634
- ^"TCS 1205 | CAS 355022-97-8 | AbMole BioScience | TCS 1205 Price".
- ^Taliani, Sabrina; Cosimelli, Barbara; Da Settimo, Federico; Marini, Anna Maria; La Motta, Concettina; Simorini, Francesca; Salerno, Silvia; Novellino, Ettore; Greco, Giovanni; Cosconati, Sandro; Marinelli, Luciana; Salvetti, Francesca; L’Abbate, Gianluca; Trasciatti, Silvia; Montali, Marina; Costa, Barbara; Martini, Claudia (25 June 2009). "Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABA A ) α 2 Benzodiazepine Receptor".Journal of Medicinal Chemistry.52(12): 3723–3734.doi:10.1021/jm9001154.