TLX3

TLX3
Identifiers
Aliases	TLX3,HOX11L2, RNX, T-cell leukemia homeobox 3, T cell leukemia homeobox 3
External IDs	OMIM:604640;MGI:1351209;HomoloGene:23181;GeneCards:TLX3;OMA:TLX3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q35.1 Start 171,309,248bp End 171,312,139bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A4 Start 33,150,752bp End 33,153,589bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in right hemisphere of cerebellum C1 segment pituitary gland anterior pituitary olfactory zone of nasal mucosa Cortex of frontal lobe female reproductive system oviduct integument zone of skin Top expressed in lumbar spinal ganglion urethra female urethra male urethra neural tube enteric nervous system trigeminal ganglion embryo ganglion of vagus nerve glossopharyngeal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component nucleus nucleoplasm Biological process multicellular organism development regulation of respiratory gaseous exchange by nervous system process cell fate specification neuron fate specification central nervous system development neuron migration regulation of transcription, DNA-templated negative regulation of neuron differentiation respiratory gaseous exchange by respiratory system neuron differentiation regulation of transcription by RNA polymerase II Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 30012 27140 Ensembl ENSG00000164438 ENSMUSG00000040610 UniProt O43711 O55144 RefSeq (mRNA) NM_021025 NM_019916 RefSeq (protein) NP_066305 NP_064300 Location (UCSC) Chr 5: 171.31 – 171.31 Mb Chr 11: 33.15 – 33.15 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

T-cell leukemia homeobox protein 3is aproteinthat in humans is encoded by theTLX3gene.

RNX (HOX11L2, TLX3) belongs to a family of orphanhomeoboxgenes that encodeDNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacingcytosinein the highly conservedhomeodomain(Dear et al., 1993).[supplied by OMIM]

Further reading

• Dear TN, Sanchez-Garcia I, Rabbitts TH (1993)."The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes".Proc. Natl. Acad. Sci. U.S.A.90(10): 4431–5.doi:10.1073/pnas.90.10.4431.PMC46525.PMID8099440.
• Bernard OA, Busson-LeConiat M, Ballerini P, et al. (2002). "A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia".Leukemia.15(10): 1495–504.doi:10.1038/sj.leu.2402249.PMID11587205.S2CID32493784.
• Ballerini P, Blaise A, Busson-Le Coniat M, et al. (2002)."HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis".Blood.100(3): 991–7.doi:10.1182/blood-2001-11-0093.PMID12130513.S2CID16589332.
• Matera I, Bachetti T, Cinti R, et al. (2003)."Mutational analysis of the RNX gene in congenital central hypoventilation syndrome".Am. J. Med. Genet.113(2): 178–82.doi:10.1002/ajmg.10746.PMID12407709.
• Mauvieux L, Leymarie V, Helias C, et al. (2003). "High incidence of Hox11L2 expression in children with T-ALL".Leukemia.16(12): 2417–22.doi:10.1038/sj.leu.2402709.PMID12454747.S2CID20611777.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Berger R, Dastugue N, Busson M, et al. (2003). "t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH)".Leukemia.17(9): 1851–7.doi:10.1038/sj.leu.2403061.PMID12970786.S2CID24379766.
• Cavé H, Suciu S, Preudhomme C, et al. (2004)."Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951".Blood.103(2): 442–50.doi:10.1182/blood-2003-05-1495.PMID14504110.
• Su XY, Busson M, Della Valle V, et al. (2004). "Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia".Genes Chromosomes Cancer.41(3): 243–9.doi:10.1002/gcc.20088.PMID15334547.S2CID19782389.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Ballerini P, Busson M, Fasola S, et al. (2005). "NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance".Leukemia.19(3): 468–70.doi:10.1038/sj.leu.2403654.PMID15674415.S2CID27045652.
• Gottardo NG, Jacoby PA, Sather HN, et al. (2005)."Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols".Leukemia.19(9): 1705–8.doi:10.1038/sj.leu.2403834.PMID15990867.
• Borghini S, Vargiolu M, Di Duca M, et al. (2006)."Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia".Mol. Cancer Res.4(9): 635–43.doi:10.1158/1541-7786.MCR-05-0250.PMID16966433.
• Nagel S, Scherr M, Kel A, et al. (2007)."Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1".Cancer Res.67(4): 1461–71.doi:10.1158/0008-5472.CAN-06-2615.PMID17308084.