TLX3
Appearance
T-cell leukemia homeobox protein 3is aproteinthat in humans is encoded by theTLX3gene.[5][6][7]
RNX (HOX11L2, TLX3) belongs to a family of orphanhomeoboxgenes that encodeDNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacingcytosinein the highly conservedhomeodomain(Dear et al., 1993).[supplied by OMIM][7]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000164438–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000040610–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Lee-Kirsch MA, Engel K, Paditz E, Rosen-Wolff A, Lee YA, Gahr M (Jul 2001)."Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34→q35 by radiation hybrid mapping".Cytogenet Cell Genet.92(3–4): 358.doi:10.1159/000056933.PMID11435718.S2CID85323468.
- ^Cinti R, Fava M, Sancandi M, Matera I, Ravazzolo R, Ceccherini I (Jul 2001). "Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization".Cytogenet Cell Genet.92(3–4): 354–5.doi:10.1159/000056931.PMID11435716.S2CID35224759.
- ^ab"Entrez Gene: TLX3 T-cell leukemia homeobox 3".
Further reading
[edit]- Dear TN, Sanchez-Garcia I, Rabbitts TH (1993)."The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes".Proc. Natl. Acad. Sci. U.S.A.90(10): 4431–5.doi:10.1073/pnas.90.10.4431.PMC46525.PMID8099440.
- Bernard OA, Busson-LeConiat M, Ballerini P, et al. (2002). "A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia".Leukemia.15(10): 1495–504.doi:10.1038/sj.leu.2402249.PMID11587205.S2CID32493784.
- Ballerini P, Blaise A, Busson-Le Coniat M, et al. (2002)."HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis".Blood.100(3): 991–7.doi:10.1182/blood-2001-11-0093.PMID12130513.S2CID16589332.
- Matera I, Bachetti T, Cinti R, et al. (2003)."Mutational analysis of the RNX gene in congenital central hypoventilation syndrome".Am. J. Med. Genet.113(2): 178–82.doi:10.1002/ajmg.10746.PMID12407709.
- Mauvieux L, Leymarie V, Helias C, et al. (2003). "High incidence of Hox11L2 expression in children with T-ALL".Leukemia.16(12): 2417–22.doi:10.1038/sj.leu.2402709.PMID12454747.S2CID20611777.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Berger R, Dastugue N, Busson M, et al. (2003). "t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH)".Leukemia.17(9): 1851–7.doi:10.1038/sj.leu.2403061.PMID12970786.S2CID24379766.
- Cavé H, Suciu S, Preudhomme C, et al. (2004)."Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951".Blood.103(2): 442–50.doi:10.1182/blood-2003-05-1495.PMID14504110.
- Su XY, Busson M, Della Valle V, et al. (2004). "Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia".Genes Chromosomes Cancer.41(3): 243–9.doi:10.1002/gcc.20088.PMID15334547.S2CID19782389.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
- Ballerini P, Busson M, Fasola S, et al. (2005). "NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance".Leukemia.19(3): 468–70.doi:10.1038/sj.leu.2403654.PMID15674415.S2CID27045652.
- Gottardo NG, Jacoby PA, Sather HN, et al. (2005)."Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols".Leukemia.19(9): 1705–8.doi:10.1038/sj.leu.2403834.PMID15990867.
- Borghini S, Vargiolu M, Di Duca M, et al. (2006)."Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia".Mol. Cancer Res.4(9): 635–43.doi:10.1158/1541-7786.MCR-05-0250.PMID16966433.
- Nagel S, Scherr M, Kel A, et al. (2007)."Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1".Cancer Res.67(4): 1461–71.doi:10.1158/0008-5472.CAN-06-2615.PMID17308084.