TRAF4
TNF receptor-associated factor 4(TRAF4) also known asRING finger protein 83(RNF83) is aproteinthat in humans is encoded by theTRAF4gene.[5][6][7]
TRAF4 is a member of the TNF receptor associated factor (TRAF) family, a family ofscaffold proteins.[8]TRAF proteins connectIL-1R/Toll andTNF receptorswith signaling factors that lead to the activation ofNF-κBandmitogen-activated protein kinases.However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.[9]
Protein interactions
[edit]TRAF4 has been shown to interact withneurotrophin receptor,p75(NTR/NTSR1),[10][11]and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind top47phox,a cytosolic regulatory factor included in a multi-protein complex known asNAD(P)H oxidase.This protein thus, is thought to be involved in the oxidative activation ofMAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.[7]
A recent report indicates that TRAF4 binds to NOD-Like Receptors NOD1 and NOD2, and specifically inhibits activation ofNF-κBby the activated NOD2-RIP2 complex[12]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000076604–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000017386–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Regnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC (Dec 1995)."Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma".J Biol Chem.270(43): 25715–21.doi:10.1074/jbc.270.43.25715.PMID7592751.
- ^Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC (Jan 1996). "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17".Genomics.28(3): 367–76.doi:10.1006/geno.1995.1163.PMID7490069.
- ^ab"Entrez Gene: TRAF4 TNF receptor-associated factor 4".
- ^Wajant H, Henkler F, Scheurich P (June 2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators".Cell. Signal.13(6): 389–400.doi:10.1016/S0898-6568(01)00160-7.PMID11384837.
- ^Kedinger V, Rio MC (2007). "TRAF4, the Unique Family Member".TNF Receptor Associated Factors (TRAFs).Advances in Experimental Medicine and Biology. Vol. 597. pp. 60–71.doi:10.1007/978-0-387-70630-6_5.ISBN978-0-387-70629-0.PMID17633017.
- ^Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (October 1999)."TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction".J. Biol. Chem.274(42): 30202–8.doi:10.1074/jbc.274.42.30202.PMID10514511.
- ^Krajewska M, Krajewski S, Zapata JM, Van Arsdale T, Gascoyne RD, Berern K, McFadden D, Shabaik A, Hugh J, Reynolds A, Clevenger CV, Reed JC (June 1998)."TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues".Am. J. Pathol.152(6): 1549–61.PMC1858434.PMID9626059.
- ^Marinis JM, Homer CR, McDonald C, Abbott DW (2011)."A Novel Motif in the Crohn's Disease Susceptibility Protein, NOD2, Allows TRAF4 to Down-regulate Innate Immune Responses".J. Biol. Chem.286(3): 1938–1950.doi:10.1074/jbc.M110.189308.PMC3023490.PMID21097508.
Further reading
[edit]- Bradley JR, Pober JS (2001)."Tumor necrosis factor receptor-associated factors (TRAFs)".Oncogene.20(44): 6482–91.doi:10.1038/sj.onc.1204788.PMID11607847.
- Masson R, Régnier CH, Chenard MP, et al. (1998)."Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development".Mech. Dev.71(1–2): 187–91.doi:10.1016/S0925-4773(97)00192-5.PMID9507120.S2CID13877166.
- Zapata JM, Pawlowski K, Haas E, et al. (2001)."A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains".J. Biol. Chem.276(26): 24242–52.doi:10.1074/jbc.M100354200.PMID11279055.
- Régnier CH, Masson R, Kedinger V, et al. (2002)."Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice".Proc. Natl. Acad. Sci. U.S.A.99(8): 5585–90.Bibcode:2002PNAS...99.5585R.doi:10.1073/pnas.052124799.PMC122813.PMID11943846.
- Xu YC, Wu RF, Gu Y, et al. (2002)."Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase".J. Biol. Chem.277(31): 28051–7.doi:10.1074/jbc.M202665200.PMID12023963.
- Glauner H, Siegmund D, Motejadded H, et al. (2002). "Intracellular localization and transcriptional regulation of tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4)".Eur. J. Biochem.269(19): 4819–29.doi:10.1046/j.1432-1033.2002.03180.x.PMID12354113.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Sax JK, El-Deiry WS (2003)."Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene".J. Biol. Chem.278(38): 36435–44.doi:10.1074/jbc.M303191200.PMID12788948.
- Fleckenstein DS, Dirks WG, Drexler HG, Quentmeier H (2003). "Tumor necrosis factor receptor-associated factor (TRAF) 4 is a new binding partner for the p70S6 serine/threonine kinase".Leuk. Res.27(8): 687–94.doi:10.1016/S0145-2126(02)00325-9.PMID12801526.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
- Ma BY, Mikolajczak SA, Danesh A, et al. (2005)."The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells".Blood.106(6): 2002–10.doi:10.1182/blood-2004-04-1622.PMID15941918.
- Takeshita F, Ishii KJ, Kobiyama K, et al. (2005). "TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF".Eur. J. Immunol.35(8): 2477–85.doi:10.1002/eji.200526151.PMID16052631.S2CID560536.
- Abell AN, Johnson GL (2006)."MEKK4 is an effector of the embryonic TRAF4 for JNK activation".J. Biol. Chem.280(43): 35793–6.doi:10.1074/jbc.C500260200.PMID16157600.