Tisopurine

Tisopurine
Clinical data
AHFS/Drugs	International Drug Names
ATC code	M04AA02(WHO);
Identifiers
	IUPAC name 1,2-Dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-thione;
CAS Number	5334-23-6;
PubChemCID	667510;
ChemSpider	580886;
UNII	79F9I2R16M;
KEGG	D07278;
CompTox Dashboard(EPA)	DTXSID90201488;
ECHA InfoCard	100.023.865
Chemical and physical data
Formula	C5H4N4S
Molar mass	152.18g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1c2c([nH]n1)ncnc2S;
	InChI InChI=1S/C5H4N4S/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10); Key:PYAOPMWCFSVFOT-UHFFFAOYSA-N;
	(verify)

Tisopurine(orthiopurinol) is adrugused in the treatment ofgoutin some countries.^[1]It reducesuric acidproduction through inhibiting an early stage in its production.^[2]

References[edit]

^Dean BM, Perrett D, Simmonds HA, Grahame R (April 1974)."Thiopurinol: comparative enzyme inhibition and protein binding studies with allopurinol, oxipurinol and 6-mercaptopurine".British Journal of Clinical Pharmacology.1(2): 119–27.doi:10.1111/j.1365-2125.1974.tb00220.x.PMC1402452.PMID 22454898.
^Jawad AS (June 1987)."Alternatives to allopurinol".Annals of the Rheumatic Diseases.46(6): 493.doi:10.1136/ard.46.6.493-a.PMC1002174.PMID 3632073.

Thisdrugarticle relating to themusculoskeletal systemis astub.You can help Wikipedia byexpanding it.

[BJClinPharm1974-1] Dean BM, Perrett D, Simmonds HA, Grahame R (April 1974)."Thiopurinol: comparative enzyme inhibition and protein binding studies with allopurinol, oxipurinol and 6-mercaptopurine".British Journal of Clinical Pharmacology.1(2): 119–27.doi:10.1111/j.1365-2125.1974.tb00220.x.PMC1402452.PMID 22454898.

[AnnRhudis1987-2] Jawad AS (June 1987)."Alternatives to allopurinol".Annals of the Rheumatic Diseases.46(6): 493.doi:10.1136/ard.46.6.493-a.PMC1002174.PMID 3632073.

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