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Overactive bladder

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Overactive bladder
Other namesOveractive bladder syndrome
SpecialtyUrology
SymptomsFrequent feeling of needing tourinate,incontinence
ComplicationsUTIs, anxiety
Usual onsetMore common with age[1]
DurationChronic
TypesAge-related, or Secondary to other illness
CausesOld age;detrusor muscleinjury; over-consumption of water and caffeine; UTI; pelvic injury
Risk factorsOld age, obesity, caffeine, constipation
Diagnostic methodBased on symptoms after ruling out other possible causes[2][1]
Differential diagnosisOtherneurological conditions[2][1]
TreatmentPelvic floor exercises,bladder training,drinking moderate fluids,weight loss,[3]medications, Botox, surgery
MedicationAnticholinergicdrugs, β3 agonists
PrognosisOften but not always incurable
Frequency~40% of elderly adults, increasing with age

Overactive bladder(OAB) is a common condition where there is a frequent feeling of needing tourinateto a degree that it negatively affects a person's life.[2]The frequent need to urinate may occur during the day,at night,or both.[4]Loss of bladder control(urge incontinence) may occur with this condition.[1]This condition is also sometimes characterized by a sudden and involuntary contraction of the bladder muscles, in response to excitement or anticipation. This in turn leads to a frequent and urgent need to urinate.

Overactive bladder affects approximately 11% of the population and more than 40% of people with overactive bladder have incontinence.[5][6]Conversely, about 40% to 70% of urinary incontinence is due to overactive bladder.[7]Overactive bladder is not life-threatening,[1]but most people with the condition have problems for years.[1]

The cause of overactive bladder is unknown.[1]Risk factors include obesity, caffeine, andconstipation.[5]Poorly controlleddiabetes,poorfunctional mobility,andchronic pelvic painmay worsen the symptoms.[1]People often have the symptoms for a long time before seeking treatment and the condition is sometimes identified by caregivers.[1]Diagnosis is based on a person's signs and symptoms and requires other problems such asurinary tract infectionsorneurological conditionsto be excluded.[2][1]Uroflowmetryis also a good diagnostic aid.[8]

The amount of urine passed during each urination is relatively small.[1]Pain while urinating suggests that there is a problem other than overactive bladder.[1]

Specific treatment is not always required.[1]If treatment is desiredpelvic floor exercises,bladder training,and other behavioral methods are initially recommended.[3]Weight lossin those who areoverweight,decreasingcaffeineconsumption, and drinking moderate fluids, can also have benefits.[3]Medications, typically of theanti-muscarinictype, are only recommended if other measures are not effective.[3]They are no more effective than behavioral methods; however, they are associated with side effects, particularly in older people.[3][9]Some non-invasive electrical stimulation methods appear effective while they are in use.[10]Injections ofbotulinum toxininto the bladder is another option.[3]Urinary cathetersorsurgeryare generally not recommended.[3]A diary to track problems can help determine whether treatments are working.[3]

Overactive bladder is estimated to occur in 7–27% of men and 9–43% of women.[1]It becomes more common with age.[1]Some studies suggest that the condition is more common in women, especially when associated with loss of bladder control.[1]Economic costs of overactive bladder were estimated in the United States at US$12.6 billion and 4.2 billion Euro in 2000.[11]

Signs and symptoms

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Overactive bladder is characterized by a group of four symptoms: urgency, urinary frequency,nocturia,and urge incontinence. Urge incontinence is not present in the "dry" classification.[12]

Urgencyis considered the hallmark symptom of OAB, but there are no clear criteria for what constitutes urgency and studies often use other criteria.[1]Urgency is currently defined by the International Continence Society (ICS), as of 2002, as "Sudden, compelling desire to pass urine that is difficult to defer." The previous definition was "Strong desire to void accompanied by fear of leakage or pain."[13]The definition does not address the immediacy of the urge to void and has been criticized as subjective.[13]

Urinary frequencyis considered abnormal if the person urinates more than eight times in a day. This frequency is usually monitored by having the person keep a voiding diary where they record urination episodes.[1]The number of episodes varies depending on sleep, fluid intake, medications, and up to seven is considered normal if consistent with the other factors.[citation needed]

Nocturiais a symptom where the person complains of interrupted sleep because of an urge to void and, like the urinary frequency component, is affected by similar lifestyle and medical factors. Individual waking events are not considered abnormal, one study in Finland established two or more voids per night as affecting quality of life.[14]

Urge incontinence is a form of urinary incontinence characterized by the involuntary loss of urine occurring for no apparent reason while feeling urinary urgency as discussed above. Like frequency, the person can track incontinence in a diary to assist with diagnosis and management of symptoms. Urge incontinence can also be measured with pad tests, and these are often used for research purposes. Some people with urge incontinence also havestress incontinenceand this can complicate clinical studies.[1]

It is important that the clinician and the person with overactive bladder both reach a consensus on the term, 'urgency.' Some common phrases used to describe OAB include, 'When I've got to go, I've got to go,' or 'When I have to go, I have to rush, because I think I will wet myself.' Hence the term, 'fear of leakage,' is an important concept to people.[15]

Causes

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The cause of OAB is usually unclear, and indeed there may be multiple causes.[16]It is often associated with overactivity of thedetrusor urinae muscle,a pattern of bladder muscle contraction observed duringurodynamics.[17]It is also possible that the increased contractile nature originates from within the urothelium and lamina propria, and abnormal contractions in this tissue could stimulate dysfunction in the detrusor or whole bladder.[18]

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If bladder spasms occur or there is no urine in the drainage bag when acatheteris in place, the catheter may be blocked by blood, thick sediment, or a kink in the catheter or drainage tubing. Sometimes spasms are caused by the catheter irritating the bladder,prostateorpenis.Such spasms can be controlled with medication such asbutylscopolamine,although most people eventually adjust to the irritation and the spasms go away.[19]

Diagnosis

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Diagnosis of OAB is made primarily on the person's signs and symptoms and by ruling out other possible causes such as an infection.[1]Urodynamics,abladder scope,and ultrasound are generally not needed.[1][20]Additionally, urine culture may be done to rule out infection. The frequency/volume chart may be maintained andcystourethroscopymay be done to exclude tumor andkidney stones.If there is an underlying metabolic or pathologic condition that explains the symptoms, the symptoms may be considered part of that disease and not OAB.[citation needed]

Psychometrically robust self-completion questionnaires are generally recognized as a valid way of measuring a person's signs and symptoms, but there does not exist a single ideal questionnaire.[21]These surveys can be divided into two groups: general surveys of lower urinary tract symptoms and surveys specific to overactive bladder. General questionnaires include: American Urological Association Symptom Index (AUASI), Urogenital Distress Inventory (UDI),[22]Incontinence Impact Questionnaire (IIQ),[22]and Bristol Female Lower Urinary Tract Symptoms (BFLUTS). Overactive bladder questionnaires include: Overactive Bladder Questionnaire (OAB-q),[23]Urgency Questionnaire (UQ), Primary OAB Symptom Questionnaire (POSQ), and the International Consultation on Incontinence Questionnaire (ICIQ).

OAB causes similar symptoms to some other conditions such asurinary tract infection(UTI),bladder cancer,andbenign prostatic hyperplasia(BPH). Urinary tract infections often involve pain andhematuria(blood in the urine) which are typically absent in OAB. Bladder cancer usually includes hematuria and can include pain, both not associated with OAB, and the common symptoms of OAB (urgency, frequency, and nocturia) may be absent. BPH frequently includes symptoms at the time of voiding as well as sometimes including pain or hematuria, and all of these are not usually present in OAB.[13]Diabetes insipiduscauses high frequency and volume, though not necessarily urgency.

Classification

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There is some controversy about the classification and diagnosis of OAB.[1][24]Some sources classify overactive bladder into two different variants: "wet" (i.e., an urgent need to urinate with involuntary leakage) or "dry" (i.e., an urgent need to urinate but no involuntary leakage). Wet variants are more common than dry variants.[25]The distinction is not absolute; one study suggested that many classified as "dry" were actually "wet" and that people with no history of any leakage may have had other syndromes.[26]

OAB is distinct fromstress urinary incontinence,but when they occur together, the condition is usually known as mixed incontinence.[27]

Management

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The usual first suggested treatment for a person with overactive bladder is a combination of lifestyle changes, exercises to strengthen the person's pelvic floor, and manage how much the person drinks and when during the day ( "fluid management" ). Patients who continue to experience incontinence episodes, or who express a desire for medication along with therapy, may be treated with several classes of drugs, notablyanticholinergics.Patients who prove resistant to medications and therapy may then be treated withneurologicalinterventions, such as treatment withbotulinum toxin(Botox) and other minimally-invasive surgical procedures, such assacral neuromodulation.As a last resort if all other treatment options fail, invasive surgical procedures may be performed.[28][29]

Lifestyle and behavioral therapy

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Behavioral and lifestyle changes are commonly recommended as the first-line option for treating overactive bladder. These include bladder training, which involves scheduled voiding (urination) and gradually increasing the time between bathroom visits. Pelvic floor exercises, known asKegel exercises,can help strengthen the muscles that control urination. Fluid management, which focuses on avoiding excessive caffeine and alcohol intake, is advised to reduce the rate at which the bladder fills and minimize irritation to the bladder. Weight management and maintaining a healthy diet contribute to overall bladder health, especially when weight loss is able to reduce abdominal compression of the bladder. Adopting these behavioral and lifestyle changes can often improve the condition and enhance the effectiveness of other treatment approaches.[28][30]

Most patients are not able to eliminate incontinence and other symptoms of OAB with lifestyle and behavioral modifications alone. However, numerous studies have demonstrated that these therapies are effective in improving quality of life, and some data shows that they increase the likelihood that medications can keep the OAB under control.[28]

Medications

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Medications are a common treatment option for people with overactive bladder syndrome. A number ofantimuscarinicdrugs (e.g.,darifenacin,hyoscyamine,oxybutynin,tolterodine,solifenacin,trospium,fesoterodine) are frequently used to treat overactive bladder.[17]Long term use, however, has been linked todementia.[31]β3 adrenergic receptoragonists (e.g.,mirabegron,vibegron) may be used, as well.[32]

Patients taking oxybutynin and other anticholinergic drugs experience a 70% reduction of incontinence episode frequency, on average. Approximately 1 in 4 patients experience complete dryness while taking oxybutynin. Therefore, medication management alone is sufficient for a substantial minority, butnotthe majority, of patients with overactive bladder.[33]

Comparison of overactive bladder medication
Agent Traits
Oxybutynin(short-acting)
  • well known by physicians
  • available in market longer than other drugs for OAB
  • many studies provide support of effectiveness
  • available as generic in places including the United States
  • more side effects than alternatives, includingdry mouthandconstipation
  • severe dry mouth more often reported
  • user takes 2-3 pills a day
Oxybutynin(extended release)
  • fewer side effects than short-acting Oxybutynin
  • 1 pill per day
Oxybutynin(transdermal patch)
  • no pill
  • patch changed every 3–4 days
  • lower rate of dry mouth as compared to pill form
  • patch commonly causes skin irritation which can be severe
Oxybutynin(Topical medication)
  • fewer side effects than short-acting Oxybutynin
  • topical gelapplied to abdomen, arms, or thighs daily
  • new on market
  • little existing research on this drug
Tolterodine(short-acting)
  • fewer side effects than short-acting Oxybutynin
  • 2 pills per day
  • 10% of Caucasians and 19% of black people have a genetic difference which causes them to lack a certain enzyme. Lack of this enzyme makes the drug less effective.
Tolterodine(extended release)
  • fewer side effects than short-acting Oxybutynin
  • 1 pill per day
  • 10% of Caucasians and 19% of black people have a genetic difference which causes them to lack a certain enzyme. Lack of this enzyme makes the drug less effective.
Solifenacin
  • 1 pill per day
  • More effective for some symptoms than Tolterodine
  • higher rates of constipation and dry mouth than tolterodine
  • less researched for safety and efficacy than Tolterodine and Oxybutynin
Trospium(short acting)
  • severe dry mouth less common than with oxybutynin
  • less researched for safety and efficacy than Tolterodine and Oxybutynin
Trospium(extended release)
  • 1 pill per day
  • little existing research on this drug
Darifenacin
  • 1 pill per day
  • less researched for safety and efficacy than Tolterodine and Oxybutynin
Fesoterodine
  • same metabolite asTolterodine,but does not require that enzyme to be active
  • it may avoid drug interactions of Tolterodine
  • little existing research on this drug

Procedures

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Botulinum toxin A (Botox) is approved by theFood and Drug Administrationin adults with neurological conditions, includingmultiple sclerosisandspinal cord injury.[34]Botulinum Toxin A injections into the bladder wall can suppress involuntary bladder contractions by blocking nerve signals and may be effective for up to 9 months.[35][36]The growing knowledge of pathophysiology of overactive bladder fueled a huge amount of basic and clinical research in this field of pharmacotherapy.[37][38][39]

Overactive bladder may be treated with electrical stimulation, which aims to reduce the contractions of themuscle that tenses around the bladderand causes urine to pass out of it. Both invasive and non-invasive electrical stimulation procedures may be used to treat overactive bladder.[10]

Invasive surgeries

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If non-invasive and pharmacological approaches are not helpful, some people may be eligible for a surgical procedure to treat overactive bladder. Surgical options may includeurinary diversion,sacral neuromodulation,or augmentation cystoplasty.[40]

One surgical intervention, called a cystoplasty, involves the enlargement of the bladder using tissue taken from the patient'sileum,which is part of the small intestine. This procedure is rarely performed, and is only done for patients who have proven resistant to all other forms of treatment. This procedure can greatly enlarge urine volume in the bladder.[41]

Prognosis

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Because overactive bladder is most commonly associated with aging, the majority of patients experience symptoms (with or without incontinence) for the rest of their lives. A minority of age-related OAB cases may be cured or indefinitely suppressed by medications and behavioral modification. If the OAB is due to a different condition, such as aurinary tract infection,then symptoms should resolve after the underlying problem has been treated.[30]

Epidemiology

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Earlier reports estimated that about one in six adults in theUnited StatesandEuropehad OAB.[42][43]The number of people affected with OAB increases with age,[42][43]thus it is expected that OAB will become more common in the future as the average age of people living in thedeveloped worldis increasing. However, a recent Finnish population-based survey[44]suggested that the number of people affected had been largely overestimated due to methodological shortcomings regarding age distribution and low participation (in earlier reports). It is suspected, then, that OAB affects approximately half the number of individuals as earlier reported.[44]

The American Urological Association reports studies showing rates as low as 7% to as high as 27% in men and rates as low as 9% to 43% in women.[1]Urge incontinence was reported as higher in women.[1]Older people are more likely to be affected, and the number of symptoms increases with age.[1]

See also

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References

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  2. ^abcdGormley EA, Lightner DJ, Faraday M, Vasavada SP (May 2015). "Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline amendment".The Journal of Urology.193(5): 1572–80.doi:10.1016/j.juro.2015.01.087.PMID25623739.
  3. ^abcdefghGormley EA, Lightner DJ, Burgio KL, Chai TC, Clemens JQ, Culkin DJ, Das AK, Foster HE, Scarpero HM, Tessier CD, Vasavada SP (December 2012). "Diagnosis and treatment of overactive bladder (non-neurogenic) in adults: AUA/SUFU guideline".The Journal of Urology.188(6 Suppl): 2455–63.doi:10.1016/j.juro.2012.09.079.PMID23098785.
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  5. ^abGibbs, Ronald S. (2008).Danforth's obstetrics and gynecology(10 ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 890–891.ISBN9780781769372.Archivedfrom the original on 2016-03-05.
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  41. ^Scarneciu, Ioan; Lupu, Sorin; Bratu, Ovidiu Gabriel; Teodorescu, Andreea; Maxim, Laurian Stefan; Brinza, Adrian; Laculiceanu, Alexandru Georgian; Rotaru, Ruxandra Maria; Lupu, Aura-Mihaela; Scarneciu, Camelia Cornelia (2021-10-14)."Overactive bladder: A review and update".Experimental and Therapeutic Medicine.22(6): 1444.doi:10.3892/etm.2021.10879.ISSN1792-1015.PMC8549091.PMID34721686.
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  44. ^abTikkinen KA, Tammela TL, Rissanen AM, Valpas A, Huhtala H, Auvinen A (February 2007). Madersbacher S (ed.)."Is the prevalence of overactive bladder overestimated? A population-based study in Finland".PLOS ONE.2(2): e195.Bibcode:2007PLoSO...2..195T.doi:10.1371/journal.pone.0000195.PMC1805814.PMID17332843.Open access icon
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