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VGF

From Wikipedia, the free encyclopedia
For other uses, seeVGF (disambiguation).
VGF
Identifiers
AliasesVGF,SCG7, SgVII, VGF nerve growth factor inducible
External IDsOMIM:602186;MGI:1343180;HomoloGene:2536;GeneCards:VGF;OMA:VGF - orthologs
Orthologs
SpeciesHumanMouse
Entrez

7425

381677

Ensembl

ENSG00000128564

ENSMUSG00000037428

UniProt

O15240

Q0VGU4

RefSeq (mRNA)

NM_003378

NM_001039385

RefSeq (protein)

NP_003369

NP_001034474

Location (UCSC)Chr 7: 101.16 – 101.17 MbChr 5: 137.06 – 137.06 Mb
PubMedsearch[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

VGForVGF nerve growth factor inducibleis a secreted protein andneuropeptideprecursor that may play a role in regulating energy homeostasis,metabolism[5]andsynaptic plasticity.[6]The protein was first discovered in 1985 by Leviet al.[7]in an experiment withPC12 cellsand its name is non-acronymic.VGF gene encodes a precursor which is divided byproteolysistopolypeptidesof different mass, which have a variety of functions, the best studied of which are the roles ofTLQP-21in the control of appetite and inflammation,[8][9][10][11][12][13][14][15]andTLQP-62as well as AQEE-30 in regulating depression-like behaviors[16][17][18][19][20]and memory.[21][22]The expression of VGF and VGF-derived peptides is detected in a subset of neurons in the central and peripheral nervous systems and specific populations of endocrine cells in theadenohypophysis,adrenal medulla,gastrointestinal tract, andpancreas.[23]VGF expression is induced byNGF,CREBandBDNFand regulated byneurotrophin-3.[24]Physical exercisesignificantly increases VGF expression in micehippocampaltissue and upregulates a neurotrophic signaling cascade thought to underlie the action ofantidepressants.[16][25][26][27]

Role in pathology

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Changes in expression of discrete VGF fragments have been detected in different neurological and psychiatric conditions. Inschizophrenia,one study has shown an increase in the VGF23-62 peptide[28]and a subsequent small study demonstrated that drugs further increase the expression, pointing at a possible ameliorating action of the fragment. A decreased expression of VGF26-62 peptide was found infrontotemporal dementia[29]and the expression of a fragment containing aminoacids 378-398 was found to be changing inamyotrophic lateral sclerosis[30]andAlzheimer's disease.[31]VGF expression has also been shown in damaged peripheral nerves, and it is thought to have a role inneuropathic pain.[32]Inglioblastoma,VGF has been shown to play autocrine and paracrine roles in feedback loops between differentiated glioblastoma cells and glioblastoma-specificcancer stem cells,promoting growth, survival and self-renewal.[33]

References

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  1. ^abcGRCh38: Ensembl release 89: ENSG00000128564–Ensembl,May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000037428–Ensembl,May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Hahm S, Mizuno TM, Wu TJ, Wisor JP, Priest CA, Kozak CA, Boozer CN, Peng B, McEvoy RC, Good P, Kelley KA, Takahashi JS, Pintar JE, Roberts JL, Mobbs CV, Salton SR (July 1999)."Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance".Neuron.23(3): 537–48.doi:10.1016/S0896-6273(00)80806-5.PMID10433265.S2CID17096284.
  6. ^Alder J, Thakker-Varia S, Bangasser DA, Kuroiwa M, Plummer MR, Shors TJ, Black IB (November 2003)."Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity".The Journal of Neuroscience.23(34): 10800–8.doi:10.1523/JNEUROSCI.23-34-10800.2003.PMC3374594.PMID14645472.
  7. ^Levi A, Eldridge JD, Paterson BM (July 1985)."Molecular cloning of a gene sequence regulated by nerve growth factor".Science.229(4711): 393–5.Bibcode:1985Sci...229..393L.doi:10.1126/science.3839317.PMID3839317.
  8. ^Bartolomucci A, La Corte G, Possenti R, Locatelli V, Rigamonti AE, Torsello A, Bresciani E, Bulgarelli I, Rizzi R, Pavone F, D'Amato FR, Severini C, Mignogna G, Giorgi A, Schininà ME, Elia G, Brancia C, Ferri GL, Conti R, Ciani B, Pascucci T, Dell'Omo G, Muller EE, Levi A, Moles A (September 2006)."TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity".Proceedings of the National Academy of Sciences of the United States of America.103(39): 14584–9.Bibcode:2006PNAS..10314584B.doi:10.1073/pnas.0606102103.PMC1600003.PMID16983076.
  9. ^Rizzi R, Bartolomucci A, Moles A, D'Amato F, Sacerdote P, Levi A, La Corte G, Ciotti MT, Possenti R, Pavone F (August 2008). "The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain".Neuroscience Letters.441(1): 129–33.doi:10.1016/j.neulet.2008.06.018.PMID18586396.S2CID207127085.
  10. ^Bartolomucci A, Moles A, Levi A, Possenti R (September 2008). "Pathophysiological role of TLQP-21: gastrointestinal and metabolic functions".Eating and Weight Disorders.13(3): e49-54.PMID19011364.
  11. ^Zhao Z, Lange DJ, Ho L, Bonini S, Shao B, Salton SR, Thomas S, Pasinetti GM (April 2008)."Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis".International Journal of Medical Sciences.5(2): 92–9.doi:10.7150/ijms.5.92.PMC2323610.PMID18432310.
  12. ^Bartolomucci A, Possenti R, Levi A, Pavone F, Moles A (November 2007)."The role of the vgf gene and VGF-derived peptides in nutrition and metabolism".Genes & Nutrition.2(2): 169–80.doi:10.1007/s12263-007-0047-0.PMC2474945.PMID18850173.
  13. ^D'Amato F, Noli B, Brancia C, Cocco C, Flore G, Collu M, Nicolussi P, Ferri GL (May 2008)."Differential distribution of VGF-derived peptides in the adrenal medulla and evidence for their selective modulation".The Journal of Endocrinology.197(2): 359–69.doi:10.1677/JOE-07-0346.PMID18434366.
  14. ^Jethwa PH, Ebling FJ (2008). "Role of VGF-derived peptides in the control of food intake, body weight and reproduction".Neuroendocrinology.88(2): 80–7.doi:10.1159/000127319.PMID18408361.S2CID207626224.
  15. ^Bartolomucci A, Bresciani E, Bulgarelli I, Rigamonti AE, Pascucci T, Levi A, Possenti R, Torsello A, Locatelli V, Muller EE, Moles A (March 2009)."Chronic intracerebroventricular injection of TLQP-21 prevents high fat diet induced weight gain in fast weight-gaining mice".Genes & Nutrition.4(1): 49–57.doi:10.1007/s12263-009-0110-0.PMC2654049.PMID19247701.
  16. ^abHunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS (December 2007). "Antidepressant actions of the exercise-regulated gene VGF".Nature Medicine.13(12): 1476–82.doi:10.1038/nm1669.PMID18059283.S2CID17245049.
  17. ^Thakker-Varia S, Krol JJ, Nettleton J, Bilimoria PM, Bangasser DA, Shors TJ, Black IB, Alder J (November 2007)."The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus".The Journal of Neuroscience.27(45): 12156–67.doi:10.1523/jneurosci.1898-07.2007.PMC3363962.PMID17989282.
  18. ^Thakker-Varia S, Alder J (February 2009)."Neuropeptides in depression: role of VGF".Behavioural Brain Research.197(2): 262–78.doi:10.1016/j.bbr.2008.10.006.PMC2648305.PMID18983874.
  19. ^Jiang C, Lin WJ, Sadahiro M, Labonté B, Menard C, Pfau ML, Tamminga CA, Turecki G, Nestler EJ, Russo SJ, Salton SR (November 2017)."VGF function in depression and antidepressant efficacy".Molecular Psychiatry.23(7): 1632–1642.doi:10.1038/mp.2017.233.PMC5962361.PMID29158577.
  20. ^Jiang, Cheng; Lin, Wei-Jye; Labonté, Benoit; Tamminga, Carol A.; Turecki, Gustavo; Nestler, Eric J.; Russo, Scott J.; Salton, Stephen R. (2018-11-20)."VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine".Neuropsychopharmacology.44(5): 971–981.doi:10.1038/s41386-018-0277-4.ISSN1740-634X.PMC6462025.PMID30504797.
  21. ^Bozdagi O, Rich E, Tronel S, Sadahiro M, Patterson K, Shapiro ML, Alberini CM, Huntley GW, Salton SR (September 2008)."The neurotrophin-inducible gene Vgf regulates hippocampal function and behavior through a brain-derived neurotrophic factor-dependent mechanism".The Journal of Neuroscience.28(39): 9857–69.doi:10.1523/jneurosci.3145-08.2008.PMC2820295.PMID18815270.
  22. ^Lin WJ, Jiang C, Sadahiro M, Bozdagi O, Vulchanova L, Alberini CM, Salton SR (July 2015)."VGF and Its C-Terminal Peptide TLQP-62 Regulate Memory Formation in Hippocampus via a BDNF-TrkB-Dependent Mechanism".The Journal of Neuroscience.35(28): 10343–56.doi:10.1523/jneurosci.0584-15.2015.PMC4502270.PMID26180209.
  23. ^Levi A, Ferri GL, Watson E, Possenti R, Salton SR (August 2004). "Processing, distribution, and function of VGF, a neuronal and endocrine peptide precursor".Cellular and Molecular Neurobiology.24(4): 517–33.doi:10.1023/B:CEMN.0000023627.79947.22.PMID15233376.S2CID36298228.
  24. ^Mandolesi G, Gargano S, Pennuto M, Illi B, Molfetta R, Soucek L, Mosca L, Levi A, Jucker R, Nasi S (January 2002)."NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction".FEBS Letters.510(1–2): 50–6.doi:10.1016/S0014-5793(01)03227-6.PMID11755530.S2CID19320196.
  25. ^Thakker-Varia S, Krol JJ, Nettleton J, Bilimoria PM, Bangasser DA, Shors TJ, Black IB, Alder J (November 2007)."The neuropeptide VGF produces antidepressant-like behavioral effects and enhances proliferation in the hippocampus".The Journal of Neuroscience.27(45): 12156–67.doi:10.1523/JNEUROSCI.1898-07.2007.PMC3363962.PMID17989282.
  26. ^Malberg JE,Monteggia LM(May 2008)."VGF, a new player in antidepressant action?".Science Signaling.1(18): pe19.doi:10.1126/stke.118pe19.PMC2745068.PMID18460680.
  27. ^Thakker-Varia S, Alder J (February 2009)."Neuropeptides in depression: role of VGF".Behavioural Brain Research.197(2): 262–78.doi:10.1016/j.bbr.2008.10.006.PMC2648305.PMID18983874.
  28. ^Huang JT, Leweke FM, Oxley D, Wang L, Harris N, Koethe D, Gerth CW, Nolden BM, Gross S, Schreiber D, Reed B, Bahn S (November 2006)."Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis".PLOS Medicine.3(11): e428.doi:10.1371/journal.pmed.0030428.PMC1630717.PMID17090210.
  29. ^Rüetschi U, Zetterberg H, Podust VN, Gottfries J, Li S, Hviid Simonsen A, McGuire J, Karlsson M, Rymo L, Davies H, Minthon L, Blennow K (December 2005). "Identification of CSF biomarkers for frontotemporal dementia using SELDI-TOF".Experimental Neurology.196(2): 273–81.doi:10.1016/j.expneurol.2005.08.002.PMID16154129.S2CID23401973.
  30. ^Ranganathan S, Williams E, Ganchev P, Gopalakrishnan V, Lacomis D, Urbinelli L, Newhall K, Cudkowicz ME, Brown RH, Bowser R (December 2005)."Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis".Journal of Neurochemistry.95(5): 1461–71.doi:10.1111/j.1471-4159.2005.03478.x.PMC1540444.PMID16313519.free full text
  31. ^Carrette O, Demalte I, Scherl A, Yalkinoglu O, Corthals G, Burkhard P, Hochstrasser DF, Sanchez JC (August 2003). "A panel of cerebrospinal fluid potential biomarkers for the diagnosis of Alzheimer's disease".Proteomics.3(8): 1486–94.doi:10.1002/pmic.200300470.PMID12923774.S2CID25445068.
  32. ^Moss A, Ingram R, Koch S, Theodorou A, Low L, Baccei M, Hathway GJ, Costigan M, Salton SR, Fitzgerald M (December 2008)."Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury".Molecular Pain.4:1744-8069–4-62.doi:10.1186/1744-8069-4-62.PMC2614976.PMID19077191.
  33. ^Wang X, Prager BC, Wu Q, Kim LJY, Gimple RC, Shi Y, et al. (April 2018)."Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression".Cell Stem Cell.22(4): 514–528.e5.doi:10.1016/j.stem.2018.03.011.PMC5947947.PMID29625067.
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