Vitamin D3 24-hydroxylase
| Vitamin D3 24-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.15.16 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDBstructures | RCSB PDBPDBePDBsum | ||||||||
| |||||||||
Vitamin D3 24-hydroxylase(EC1.14.15.16,CYP24A1) is anenzymewithsystematic namecalcitriol,NADPH:oxygen oxidoreductase (24-hydroxylating).[1][2][3][4][5][6][7]This enzymecatalysesthe followingchemical reaction
- (1) calcitriol + NADPH + H++ O2calcitetrol + NADP++ H2O
- (2) calcidiol + NADPH + H++ O2secalciferol + NADP++ H2O
Vitamin D3 24-hydroxylase is aheme-thiolateenzyme (P-450).
References[edit]
- ^Masuda S, Strugnell SA, Knutson JC, St-Arnaud R, Jones G (February 2006). "Evidence for the activation of 1 Alpha -hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: delineation of pathways involving 1 Alpha,24-dihydroxyvitamin D2 and 1 Alpha,25-dihydroxyvitamin D2".Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.1761(2): 221–34.doi:10.1016/j.bbalip.2006.01.004.PMID16516540.
- ^Hamamoto H, Kusudo T, Urushino N, Masuno H, Yamamoto K, Yamada S, Kamakura M, Ohta M, Inouye K, Sakaki T (July 2006). "Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats".Molecular Pharmacology.70(1): 120–8.doi:10.1124/mol.106.023275.PMID16617161.S2CID7458859.
- ^Sakaki T, Kagawa N, Yamamoto K, Inouye K (January 2005)."Metabolism of vitamin D3 by cytochromes P450".Frontiers in Bioscience.10:119–34.doi:10.2741/1514.PMID15574355.
- ^Prosser DE, Kaufmann M, O'Leary B, Byford V, Jones G (July 2007)."Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1 Alpha,25-(OH)2D3-26,23-lactone".Proceedings of the National Academy of Sciences of the United States of America.104(31): 12673–8.Bibcode:2007PNAS..10412673P.doi:10.1073/pnas.0702093104.PMC1937525.PMID17646648.
- ^Kusudo T, Sakaki T, Abe D, Fujishima T, Kittaka A, Takayama H, Hatakeyama S, Ohta M, Inouye K (September 2004). "Metabolism of A-ring diastereomers of 1 Alpha,25-dihydroxyvitamin D3 by CYP24A1".Biochemical and Biophysical Research Communications.321(4): 774–82.doi:10.1016/j.bbrc.2004.07.040.PMID15358094.
- ^Sawada N, Kusudo T, Sakaki T, Hatakeyama S, Hanada M, Abe D, Kamao M, Okano T, Ohta M, Inouye K (April 2004). "Novel metabolism of 1 Alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1".Biochemistry.43(15): 4530–7.doi:10.1021/bi030207f.PMID15078099.
- ^Prosser DE, Jones G (December 2004). "Enzymes involved in the activation and inactivation of vitamin D".Trends in Biochemical Sciences.29(12): 664–73.doi:10.1016/j.tibs.2004.10.005.PMID15544953.
External links[edit]
- Vitamin+D3+24-hydroxylaseat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
