Y box binding protein 1
(Redirected fromYBX1)
Y box binding protein 1also known asY-box transcription factorornuclease-sensitive element-binding protein 1is aproteinthat in humans is encoded by theYBX1gene.[5]YBX1 is an RNA binding protein[6]that stabilises messenger RNAs modified with N6-methyladenosine.[7]
Clinical significance
[edit]YBX1 is a potential drug target in cancer therapy.[8]YB-1 helps the replication ofadenovirustype 5, a commonly used vector ingene therapy.[8]Thus, YB-1 can cause an"oncolytic" effectin YB-1 positive cancer cells treated with adenoviruses.
Interactions
[edit]Y box binding protein 1 has been shown tointeractwith:
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000065978–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000028639–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^EntrezGene4904YBX1 Y-box binding protein 1
- ^Kwon E, Todorova K, Wang J, Horos R, Lee KK, Neel VA, et al. (April 2018)."The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level".Nature Communications.9(1): 1734.Bibcode:2018NatCo...9.1734K.doi:10.1038/s41467-018-04092-0.PMC5928080.PMID29712925.
- ^Feng M, Xie X, Han G, Zhang T, Li Y, Li Y, et al. (July 2021)."YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner".Blood.138(1): 71–85.doi:10.1182/blood.2020009676.PMC8667054.PMID33763698.
- ^abLage H, Surowiak P, Holm PS (November 2008)."[YB-1 as a potential target in cancer therapy]".Der Pathologe(in German).29(Suppl 2): 187–190.doi:10.1007/s00292-008-1030-2.PMID18773210.
- ^abKojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, et al. (May 2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle".Journal of Molecular Biology.339(2): 313–325.doi:10.1016/j.jmb.2004.03.071.PMID15136035.
- ^Chernukhin IV, Shamsuddin S, Robinson AF, Carne AF, Paul A, El-Kady AI, et al. (September 2000)."Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF".The Journal of Biological Chemistry.275(38): 29915–29921.doi:10.1074/jbc.M001538200.PMID10906122.
- ^Okamoto T, Izumi H, Imamura T, Takano H, Ise T, Uchiumi T, et al. (December 2000)."Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression".Oncogene.19(54): 6194–6202.doi:10.1038/sj.onc.1204029.PMID11175333.
- ^Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, et al. (January 1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen".Cancer Research.59(2): 342–346.PMID9927044.
- ^Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (December 2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1".Journal of Molecular Biology.384(4): 908–916.doi:10.1016/j.jmb.2008.09.060.PMID18851979.
- ^Raffetseder U, Frye B, Rauen T, Jürchott K, Royer HD, Jansen PL, et al. (May 2003)."Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection".The Journal of Biological Chemistry.278(20): 18241–18248.doi:10.1074/jbc.M212518200.PMID12604611.
Further reading
[edit]- Kolluri R, Torrey TA, Kinniburgh AJ (January 1992)."A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif".Nucleic Acids Research.20(1): 111–116.doi:10.1093/nar/20.1.111.PMC5356827.PMID1738588.
- Kolluri R, Kinniburgh AJ (September 1991)."Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein".Nucleic Acids Research.19(17): 4771.doi:10.1093/nar/19.17.4771.PMC328725.PMID1891370.
- Sakura H, Maekawa T, Imamoto F, Yasuda K, Ishii S (December 1988). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology".Gene.73(2): 499–507.doi:10.1016/0378-1119(88)90514-8.PMID2977358.
- Didier DK, Schiffenbauer J, Woulfe SL, Zacheis M, Schwartz BD (October 1988)."Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box".Proceedings of the National Academy of Sciences of the United States of America.85(19): 7322–7326.Bibcode:1988PNAS...85.7322D.doi:10.1073/pnas.85.19.7322.PMC282178.PMID3174636.
- Kudo S, Mattei MG, Fukuda M (July 1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain".European Journal of Biochemistry.231(1): 72–82.doi:10.1111/j.1432-1033.1995.tb20672.x(inactive 2024-06-08).PMID7628487.
{{cite journal}}:CS1 maint: DOI inactive as of June 2024 (link) - Lloberas J, Maki RA, Celada A (September 1995)."Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins".Molecular and Cellular Biology.15(9): 5092–5099.doi:10.1128/mcb.15.9.5092.PMC230756.PMID7651426.
- Chen NN, Chang CF, Gallia GL, Kerr DA, Johnson EM, Krachmarov CP, et al. (February 1995)."Cooperative action of cellular proteins YB-1 and Pur Alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element".Proceedings of the National Academy of Sciences of the United States of America.92(4): 1087–1091.Bibcode:1995PNAS...92.1087C.doi:10.1073/pnas.92.4.1087.PMC42642.PMID7862639.
- Horwitz EM, Maloney KA, Ley TJ (May 1994)."A human protein containing a" cold shock "domain binds specifically to H-DNA upstream from the human gamma-globin genes".The Journal of Biological Chemistry.269(19): 14130–14139.doi:10.1016/S0021-9258(17)36764-9.PMID8188694.
- Kashanchi F, Duvall JF, Dittmer J, Mireskandari A, Reid RL, Gitlin SD, et al. (January 1994)."Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression".Journal of Virology.68(1): 561–565.doi:10.1128/JVI.68.1.561-565.1994.PMC236322.PMID8254772.
- Makino Y, Ohga T, Toh S, Koike K, Okumura K, Wada M, et al. (May 1996)."Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter".Nucleic Acids Research.24(10): 1873–1878.doi:10.1093/nar/24.10.1873.PMC145870.PMID8657568.
- Funke B, Zuleger B, Benavente R, Schuster T, Goller M, Stévenin J, et al. (October 1996)."The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins".Nucleic Acids Research.24(19): 3821–3828.doi:10.1093/nar/24.19.3821.PMC146158.PMID8871564.
- Koike K, Uchiumi T, Ohga T, Toh S, Wada M, Kohno K, et al. (November 1997)."Nuclear translocation of the Y-box binding protein by ultraviolet irradiation".FEBS Letters.417(3): 390–394.Bibcode:1997FEBSL.417..390K.doi:10.1016/S0014-5793(97)01296-9.PMID9409758.S2CID24656107.
- Toh S, Nakamura T, Ohga T, Koike K, Uchiumi T, Wada M, et al. (January 1998). "Genomic organization of the human Y-box protein (YB-1) gene".Gene.206(1): 93–97.doi:10.1016/S0378-1119(97)00570-2.PMID9461420.
- Sawaya BE, Khalili K, Amini S (February 1998)."Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat".The Journal of General Virology.79. 79 ( Pt 2) (2): 239–246.doi:10.1099/0022-1317-79-2-239.PMID9472608.
- Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH (December 1998)."A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription".The Journal of Biological Chemistry.273(49): 32957–32965.doi:10.1074/jbc.273.49.32957.PMID9830047.
- Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, et al. (January 1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen".Cancer Research.59(2): 342–346.PMID9927044.
- Safak M, Gallia GL, Khalili K (April 1999)."Reciprocal interaction between two cellular proteins, Pur Alpha and YB-1, modulates transcriptional activity of JCVCY in glial cells".Molecular and Cellular Biology.19(4): 2712–2723.doi:10.1128/mcb.19.4.2712.PMC84064.PMID10082537.
- Kelm RJ, Cogan JG, Elder PK, Strauch AR, Getz MJ (May 1999)."Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle Alpha -actin promoter".The Journal of Biological Chemistry.274(20): 14238–14245.doi:10.1074/jbc.274.20.14238.PMID10318844.
- Safak M, Gallia GL, Ansari SA, Khalili K (December 1999)."Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen".Journal of Virology.73(12): 10146–10157.doi:10.1128/JVI.73.12.10146-10157.1999.PMC113067.PMID10559330.
- Ansari SA, Safak M, Gallia GL, Sawaya BE, Amini S, Khalili K (October 1999)."Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity".The Journal of General Virology.80. 80 ( Pt 10) (10): 2629–2638.doi:10.1099/0022-1317-80-10-2629.PMID10573156.
- Basaki Y, Hosoi F, Oda Y, Fotovati A, Maruyama Y, Oie S, et al. (April 2007)."Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells".Oncogene.26(19): 2736–2746.doi:10.1038/sj.onc.1210084.PMID17072343.
External links
[edit]- YBX1+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
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This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.