Jump to content

ZCZ-011

Add links
From Wikipedia, the free encyclopedia
ZCZ-011
Identifiers
  • 6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
PDB ligand
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC21H18N2O2S
Molar mass362.45g·mol−1
3D model (JSmol)
  • Cc1ccc2c([nH]c(c3ccccc3)c2C(C[N+]([O-])=O)c4sccc4)c1
  • InChI=1S/C21H18N2O2S/c1-14-9-10-16-18(12-14)22-21(15-6-3-2-4-7-15)20(16)17(13-23(24)25)19-8-5-11-26-19/h2-12,17,22H,13H2,1H3
  • Key:RJSPNRDBWHHFMH-UHFFFAOYSA-N

ZCZ-011is a positiveallosteric modulatorof thecannabinoidCB1receptor.[1][2]

See also

[edit]

References

[edit]
  1. ^Poklis JL, Clay DJ, Ignatowska-Jankowska BM, Zanato C, Ross RA, Greig IR, et al. (June 2015)."HPLC-MS-MS Determination of ZCZ-011, A Novel Pharmacological Tool for Investigation of the Cannabinoid Receptor in Mouse Brain Using Clean Screen FASt™ Column Extraction".Journal of Analytical Toxicology.39(5): 353–8.doi:10.1093/jat/bkv015.PMC4542657.PMID25737338.
  2. ^Ignatowska-Jankowska BM, Baillie GL, Kinsey S, Crowe M, Ghosh S, Owens RA, et al. (December 2015)."A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects".Neuropsychopharmacology.40(13): 2948–59.doi:10.1038/npp.2015.148.PMC4864630.PMID26052038.
Stub icon

Thiscannabinoidrelated article is astub.You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=ZCZ-011&oldid=1101288287"